Oral use - eating valium suppository

[brandi29]

Swim has some valium suppository and wonders if you eat it will it still work? Swim isn't feeling the effects of the supporsitory rectually.

Reputation Comments on this post:

You severve these seen as how a resonable post was ruined.

[Panthers007]

Yesterday it was can you take Valium rectally? Today it's can you eat a Valium suppository! What next (he dreads to ask)?

[fnord]

Anal absorption should be the best method,maybe your monkey need to try a larger dose? What dose is monkey taking? Im not sure but i assume anything designed to go up ones bum bum should be nontoxic so eating it while ucky shouldn't be harmful.

[Solinari]

The rectal diazepam i have seen comes in a liquid form and seems to be dissolved in something like propylene glycol. I am not sure how it comes in this instance but if it isn't dissolved in some alcohol and the other ingredients seem innocuous then i don't see any reason why it couldn't be eaten.

One thing i am confused about, as far as i know diazepam does not have any local effect, it has to be absorbed in to the blood stream and then has an effect in the central nervous system. I can't see how it can affect just one muscle in a local way, i don't understand this.

I also think that it should have just as much an effect rectally (or even vaginally) as it does orally, if not more so, and the onset should be much faster. If it hasn't been used as directed already then i think the doctors directions should be followed.

[brandi29]

They are solid suppositorys. Believe it or not using them vaginally when you have pelvic floor dysfuction which just means your muscles like to spasm so much in is so painful. Valium is the best muscle relaxer. I am not sure how they help, but swim has a RX for them and put them into the vaginal and it really helps so much but don't feel the side effects from them. They come from a special compounded pharmacy it takes 2 days to be made. Not really sure what are made in them but swim say they are blue solid suppository. I will try to research this more.

[Solinari]

I have never ever heard of diazepam having a direct local effect on a muscle, as far as i know it doesn't work like that. I am 99% sure diazepam has to bind to the receptor in the brain before it has any effect. If it is absorbed then it's absorbed even in a muscle it will get in to the blood stream, but i just can't see how it can bind to anything in a specific muscle and have a local effect. Never the less, i would follow the doctors instructions as long as it's been explained in person and hasn't been misinterpreted by either yourself or the pharmacy.

[drug-bot]

Originally Posted by Solinari

I have never ever heard of diazepam having a direct local effect on a muscle, as far as i know it doesn't work like that. I am 99% sure diazepam has to bind to the receptor in the brain before it has any effect. If it is absorbed then it's absorbed even in a muscle it will get in to the blood stream, but i just can't see how it can bind to anything in a specific muscle and have a local effect. Never the less, i would follow the doctors instructions as long as it's been explained in person and hasn't been misinterpreted by either yourself or the pharmacy.

your right it doesnt have any local effect, the diazapam suppository is for people who suffer sever and frequent seizures, its expected by the prescribing doctor they will have a care-giver to insert the suppository when the individual is having a seivure, as diazapam is very effective for treating a person having seizure.

[Politicalchalk]

Back to the topic though......ewwwwwww.

Anything designed to go in yer ass......actually digesting propylene glycol can't be healthy......in this case, one recommends just biting the bullet, to borrow a phrase and not borrow one. Ere, not biting, but....

Just shove the damn thing up your ass.

[Solinari]

Apparently this isn't like Stesolid tubes but is made up in the chemist as some sort of solid tablet suppository. They are also suppose to be blue which could indicate it is a pulverised 10mg tablet (why else would it be blue?) that has been mixed up with something else, Brandi suggests coca butter. Of course this is just a guess, i have no idea what these things look like but if the diazepam hasn't been dissolved in propylene glycol or something similar then i don't see any reason why they couldn't be eaten. Never the less, i think it's best to use them as directed because there is no reason why they shouldn't be just as effective and probably faster acting.

[Politicalchalk]

Even with rectal administration, Swim thinks it would still take between 10-20 mins to kick in. Benzodiazepines used to treat seizures are usually given I.V., as the almost immediate onset of action is necessary. A trained care-giver would be able to an IV.

Swim's cat always thought that rectal admin was reserved for people having trouble taking meds orally. When the cat was first put on lithium he had some GI upset, and in the midst of a severe heat wave, very intense bouts of nausea and vomiting, so a compazine suppository was Rxed, as he could not keep down the anti-nausea tablets. Rectal does increase the absorption of the drug, and perhaps some nominal differences in the actual speed of onset, but the cat keeps insisting that it would take too long to stop a seizure by rectal administration. If seizures are regular (ie: epilepsy or some other chronic condition), than anti-convulsants would be prescribed as part of a long-term med regimen, with the occasional (hopefully) fast acting IV dose for what, I suppose, could be called "breakthrough seizures."

Nota Bene: the above information is based on an educated guess from the cat. The template was chronic pain. The cat's not too up to speed on seizure info, but has a little experience, as the cat's sexy feline companion had employment as a home-care aide for people with epilespy, down syndrome, autism, etc etc etc.

[fnord]

Brandi did you friend end up ating it? please post results!

[Solinari]

It would very difficult to give an IV injection to someone having a seizure, i have seen someone seizing and they are so rigid and shake violently that it would be almost impossible to get a vein and complete an injection.

Stesolid rectal tubes seem to be the standard way to stop a seizure, the person i saw having a seizure had them and my mother who is a carer had to attend a training course to administer them.

[Politicalchalk]

Perhaps this is another one of those differences between US and UK doctors. In a controlled setting anyways, there would be enough trained staff to hold the person down, perhaps already having one of those nifty (*ahem, in the hospital) IV connective thingeys already in place. Obviously one wouldn't have it in all the time, but I feel pretty confidant support the IV hypothesis.

Will do some investigation and respond soon.

Politicalchalk added 52 Minutes and 23 Seconds later...

Swim's cat has an aunt who works as a nurse at Smizney World in Florida, has been a traveling nurse all her adult life. When posed the question, "How are (chronic) seizures controlled when a person is actually seizing?"

Her reply was that (as first line treatment) at home, usually the route is oral, and in a hospital setting it is intravenous. She listed 3 drugs primarily used, to wit: Phenytoin (Dilantin), Fosphenytoin (Cerebyx), and Phenobarbital.

Now, this is clearly a subjective observation based purely on experience and won't hold true to every situation and individual body chemistry, but the cat expressed a good amount of faith in CatAunt.

Rectal administration was not mentioned. Again though, this is a US-centric observation.

This does bring up an interesting point about refractory seizures in which first line drugs are not effective. The Wikipedia lists a few dozen drugs that have been used throughout the ages with varying ranges of efficacy (including pregabalin, which swim found interesting!). Drug response and tolerance is highly subjective, and even subject to rotation or outright change.

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From the Journal of Clinical Neurology, 2007:

"Pharmacologic considerations in the treatment of repetitive or prolonged seizures."

Seizure emergencies are relatively common; however, in-hospital emergency care often is delayed by a variety of factors. Home-based treatment is effective at interrupting prolonged or repetitive seizures, but this option is underused despite its wide availability. The choice of agent used to treat seizure emergencies will depend chiefly on differences among the properties of the available drugs, particularly with regard to route of administration, lipid solubility, formulation characteristics, and the relative size of the absorptive surface area. These factors also can play a part in the decision to use one route of administration over another. Intravenous administration is the fastest and most reliable method of drug delivery, but alternative methods of drug delivery include oral, intramuscular, buccal, nasal, and rectal routes.
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[Solinari]

I am sure in a hospital setting with an intravenous cannula already in place then IV would be the route to use. I was referring to a one on one situation in a house (or even out and about) where there isn't a trained medical professional. I am not so sure about the oral route either, from the seizures i have seen there is no way someone could swallow a tablet and by the time it took effect the seizure would be over.

[brandi29]

Btw, it isn't the one that some one would already put in the butt. That would be gross. The does is 10mg. I did research and valium rectually isn't the best way to take that medicine. I know other drugs that is the best method but not valium. Swim had it compounded at a special pharmacy for vaginal use for pelvic floor muscle problems to help relax the muscle. But, the directions say, use it rectally, but doctor said use vaginal. I am not sure why ya find it gross to eat the suppository when mostly they are made with cocca butter and such. It isn't like I would put it in my butt and then eat it.

Reputation Comments on this post:

LOL! Good point.