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Old 20-06-2008, 11:21
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Accepted Threshold Dose for Subjective Intoxication by Ethanol?

Hi community,

SWIM is curious as to what the accepted threshold dose in mg/kg for subjective ethanol intoxication in low-tolerance, 20-30 year old males is. SWIM has perused various free-ish journal sources, and has only come upon dose response curves for addicts or members of post addiction-recovery programs. These are the current numbers SWIM has as a working context for comparison:

the threshold dose to induce chronic alcoholic skeletal myopathy is 10 kg ethanol/kg.

heart diastolic disfunction starts at 100/kg/daily dose of ethanol.

The time course of blood ethanol concentration is similar in all 4 age groups of males, 20–29, 30–39, 40–49 and 50–59 years, with resulting intoxication for 50–59-year-old men on the highest level and 20–29-year-old men lowest. They drank 0.68 g/kg ethanol as neat whisky after fasting overnight. The drink was finished within 20 min.

For reference, SWIM found that 60mL (roughly 2 shots) of 45% ethanol by volume (90 proof) came to be 10.53 mg. ethanol. All of the above numbers, aside from the last, provide a relatively one sided basis for understanding. Any words-from-the-wise?
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