Overdose - Amount of Tylenol swim should take in one day

[eklypised]

Is it okay to take 5000mgs of tylenol in one day?

[dark12]

The general rule around here is not to intake more than 4g of Acetaminophen in 24 hours.
I would recommend a cold water extraction if you will be taking that much of a x/APAP opiate. The search function will lead you to a thread that explains the process.

[Panthers007]

4,000mg is the maximum/day. But this also implies this is for short periods of time. Not 4,000mg every day of the week/life.

SWIM should learn the CWE technique as soon as possible - and use it. Liver and kidney transplants are no fun. Or trips to the graveyard.

[OhCasey]

over under 15 redundant replies in the next two days on this topic.

[Orchid_Suspiria]

How about none?Swim made the decision to never take tylenol again and thinks everyone else might be well off doing this.Nasty,toxic stuff.

Reputation Comments on this post:

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[cra$h]

Originally Posted by Orchid_Suspiria

How about none?Swim made the decision to never take tylenol again and thinks everyone else might be well off doing this.Nasty,toxic stuff.

swim has done almost the same thing, and has become scared of the drug, and refraining use even as it's directed. plus it gives swim a stomache ache, so it's a lose-lose situation.

[Solinari]

Probably would be OK to take 5000mg in 24 hours one time, but certainly not for something like 2 days in a row. Oh and definitely no more than 1000mg at any one time, with 6 hours in between dosing. I remember watching a program about medical use of heroin for addicts and how a doctor said how toxic paracetamol was, she said taking double the dose of a prescribed dose of heroin would be pretty much harmless, but taking double the recommended dose of paracetamol and you could do some nasty damage.

I think it might have Panthers007 that said in a post about how it builds up in the body so less and less would have to be taken each day if it was used for any prolonged period of time. Paracetamol is usually a for colds/flu, toothache, headache or any temporary ailment, so it's like 4g in 24 hours for one pack of say 16 tablets. For teh next pack i wouldn't go with more than 750mg at any one time and 3000mg in 24 hours.

[eklypised]

How long does it take before your liver starts to become affected from Acetaminophen? Is it years, months, days? I know a women who has been on opiates for about 16 years..im sure her liver isnt in to good of shape.

[Lobsang]

How long does it take before your liver starts to become affected from Acetaminophen? Is it years, months, days? I know a women who has been on opiates for about 16 years..im sure her liver isnt in to good of shape.

Well actually if you stay under the maximum daily dose per day you are not likley to get liver dysfunction even over a long period of time. Liver problems from acetaminophen are generally seen with high toxic doses taken at once or over a short period. And you really never want to combine any amount of it with alcohol or use it if you are an alcoholic. Rare liver reactions can happen.

[Solinari]

I imagine there is a safety margin with these recommended doses (at any one time and 24 hours) but it isn't much. I am sure it would be fine to take 1500mg of paracetamol at one time very occasionally, and i am sure it would be fine to take say 5000mg of paracetamol over 24 hours very occasionally as well.

Paracetamol is just a toxic drug, there is a large section on Wikipedia about Paracetamol Toxicity. Apparently "paracetamol toxicity is, by far, the most common cause of acute liver failure in both the United States and the United Kingdom".

It mentions suicide by paracetamol overdose, man, there are some horrible ways to kill yourself, hanging without breaking the neck (asphyxiation) or some gory way to bleed out with sheer panic as your arterial spray covers the walls. I would take any of those before trying to do myself in with paracetamol, horrible horrible, slow way to die. I have heard of someone doing it, they lived, it was a cry for help but some people won't tell anyone and then turn yellow and start to die a horrible death.

[Raw edge]

Interesting that everyone is saying 4,000mg per day. That is the limit in Ireland too. In spain the daily limit recommended is 6,000mg.

Originally Posted by Solinari

I imagine there is a safety margin with these recommended doses (at any one time and 24 hours) but it isn't much. I am sure it would be fine to take 1500mg of paracetamol at one time very occasionally, and i am sure it would be fine to take say 5000mg of paracetamol over 24 hours very occasionally as well.

Paracetamol is just a toxic drug, there is a large section on Wikipedia about Paracetamol Toxicity. Apparently "paracetamol toxicity is, by far, the most common cause of acute liver failure in both the United States and the United Kingdom".

It mentions suicide by paracetamol overdose, man, there are some horrible ways to kill yourself, hanging without breaking the neck (asphyxiation) or some gory way to bleed out with sheer panic as your arterial spray covers the walls. I would take any of those before trying to do myself in with paracetamol, horrible horrible, slow way to die. I have heard of someone doing it, they lived, it was a cry for help but some people won't tell anyone and then turn yellow and start to die a horrible death.

[0utrider]

Melt. point 169 °C (336 °F)
Boiling point:
Solubility in water 0.1-0.5 g/100 mL at 22 C mg/mL (20 °C)
CWE: Filtration possible by using CWE (cold water!!). Doesn't stay in the water, if done properly.Very slightly soluble in cold water, considerably more soluble in hot water . Soluble in methanol, ethanol, dimethylformamide, ethylene dichloride, acetone, ethyl acetate. Slightly soluble in ether. Practically insol in petr ether, pentane, benzene.
Dosage: It seems, even though there is an individual lvl, that one can take quite a large dose once, way less if on a regular basis. It seems to be safe (meaning not necessarily irreversible harming! Its still dangerous!!!) to take up to 4000mg once, one is on the safer side if (s)he goes by
Quote:
Optimal adult dosing appears to be somewhere in the 20 to 30 mg/kg Source
and doesnt OD on this. If taken regulary/daily, its a lot less and it should not be taken regular!
Side-effects: Because of the wide availability of paracetamol, there is a large potential for overdose and toxicity. Without timely treatment, overdose can lead to liver failure and death within days; paracetamol toxicity is, by far, the most common cause of acute liver failure in both the United States and the United Kingdom. It is sometimes used in suicide attempts by those unaware of the prolonged timecourse and high morbidity (likelihood of significant illness) associated with paracetamol-induced toxicity in survivors.
http://en.wikipedia.org/wiki/Acetaminophen
for more info look at the poisoning section of this faq
Grapefruit juice and APAP. GPJ is an inhibitor of CYP3A4, which is a minor
metabolizer of hydrocodone and a major
metabolizer of acetaminophen. What this means is that degree to
which plasma concentrations of acetaminophen increase would be much
greater than the degree to which plasma levels of hydrocodone would
increase; thus the risk of liver toxicity is actually higher.


PCM Poisoning: Acetylcysteine
PCM Poisoning Experiences, Infos & Discussion Thread
Acetylcysteine as antidote: overdosed toxic itself, drinking lots of water always recommended due to possible harm to kidneys)

"Administration of activated charcoal should be considered if paracetamol in excess of 150 mg/kg or 12 g whichever is the smaller, is thought to have been ingested within the previous hour.

Acetylcysteine protects the liver if infused within 24 hours of ingesting paracetamol. It is most effective if given within 8 hours of ingestion after which effectiveness declines sharply; if more than 24 hours have elapsed advice should be sought from a poisons information centre or from a liver unit on the management of serious liver damage. In remote areas methionine (2.5 g) by mouth is an alternative if acetylcysteine cannot be given promptly. Once the patient reaches hospital the need to continue treatment with the antidote will be assessed from the plasma-paracetamol concentration (related to the time from ingestion).

Patients at risk of liver damage and therefore requiring treatment can be identified from a single measurement of the plasma-paracetamol concentration, related to the time from ingestion, provided this time interval is not less than 4 hours; earlier samples may be misleading. The concentration is plotted on a paracetamol treatment graph of a reference line (‘normal treatment line') joining plots of 200 mg/litre (1.32 mmol/litre) at 4 hours and 6.25 mg/litre (0.04 mmol/litre) at 24 hours. Those whose plasma-paracetamol concentration is above the normal treatment line are treated with acetylcysteine by intravenous infusion (or, if acetylcysteine is not available, with methionine by mouth, provided the overdose has been taken within 10–12 hours and the patient is not vomiting).

Patients on enzyme-inducing drugs (e.g. carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, alcohol, and St John’s wort) or who are malnourished (e.g. in anorexia, in alcoholism, or those who are HIV-positive) may develop toxicity at lower plasma-paracetamol concentration and should be treated if the concentration is above the high-risk treatment line (which joins plots that are at 50% of the plasma-paracetamol concentrations of the normal treatment line).

The prognostic accuracy of plasma-paracetamol concentration taken after 15 hours is uncertain but a concentration above the relevant treatment line should be regarded as carrying a serious risk of liver damage.
Plasma-paracetamol concentration may be difficult to interpret when paracetamol has been ingested over several hours. If there is doubt about timing or the need for treatment then the patient should be treated with an antidote." thanks to Jatelka.


ım my sıgnature ıs a lınk to a CWE faq ıncludıng extractıon manuals..

[iluvlory]

jesus god no ive actually seen some one ingest around 7,000mg in one dose taking darvocets and he was ok but i think he was EXTREMLY lucky try to keep the dose under 4000mg in a 24hr peroid

[Solinari]

That is just crazy, who ever had done that was very lucky they didn't turn yellow, and they may yet have done some damage that isn't apparent at the moment but could well appear later in life especially if it is exacerbated with alcohol.

Taking a huge dose of paracetamol to get effects from oxycodone or hydrocodone is bad enough, but doing it to try and get effects from fucking dextropropoxyphene (darvocets) is just crazy, not least because it's generally considered a very weak drug with low abuse potential. I could understand doing a cold water extraction and taking it, but taking it with the paracetamol, nearly double the maximum 24 hour dose in one time is tantamount to suicide.

[Ganja Joe]

My pharmacist told me 2000mg is the daily limit.

[dark12]

To be honest SWIM didn't know it was that strict. SWIM admits to taking 3.5g of acetaminophen in single vicodin binges once or twice in his life. SWIM is pretty freaked out now. /

[Solinari]

I wouldn't be too worried about it, i am sure it is possible to get away with it once or twice, as long as it's not like 2 days in a row.

Paracetamol is very toxic, and it scares me to think the amount of kids that see a bottle of pills with the name Vicodin or Percocet on it. All they know is they can get high off them, but probably don't know about the paracetamol or even care about it, thinking it would be fine to double the prescribed dose or worse. It's probably happening right at this moment some where in some house in some city.

[Panthers007]

A friend of mine's sister took a lethal overdose of acetaminophen (paracetamol) in Canada. She wanted to get high off the codeine in these OTC - Tylenol 1. They got her to the hospital where they reversed the codeine with Naloxone. But it was too late to do anything about the acetaminophen. Her liver and kidneys had been destroyed. Rather then have her face the inevitable slow death - they put her into a drug-induced coma.

[Lobsang]

Yeah...I knew of this kid that OD'd on Tylenol and then had second thoughts about about dying. But it was too late. They told him he was going to die. He was pacing around freaking out about it..All upset. A bad scene all together. The family was asking for a transplant. But they were told that it would not even be considered because he had cocaine in his system. And policy is/was that they do not transplant on drug users that have not been clean for a certain length of time even if there is an available liver. I asked someone why this was policy and they indicated that the patient would just screw up the next liver or their body so they were not a good candidate. I think it is more like the patient is being punished for using drugs.

they put her into a drug-induced coma.

Yeah...That must be kind of weird. The doctors come in and tell you that they are puttting you to sleep and you will never wake up. Actually they use this technique with rabies victums I believe and one did survive..

[Solinari]

If it involved an extremely unmanageable painful death then induced coma is pretty much the best thing to do, it gives them a very very slight chance of recovery (liver has a remarkable ability to regenerate) and i suppose it gives the family hope.

If the pain and death was manageable and there would be some quality of life, then i would want to live out the rest of my days to the fullest. Just to think someone is probably trying to get high off co-codamol right now while using a deadly if not extremely damaging amount of paracetamol.

[Lobsang]

If it involved an extremely unmanageable painful death then induced coma is pretty much the best thing to do, it gives them a very very slight chance of recovery (liver has a remarkable ability to regenerate) and i suppose it gives the family hope.

Well actually. If they put you in a coma they are 100% sure that you are going to die. They can tell from a biopsy. The liver has regenerative ability to an extent but now beyond a certain point. When you dissolve your liver with Tylenol it is gone, fried, melted, nada, history. Never to come back again

[The 719]

Relatively new around here, but Swim has recently encountered a few discussion sililar to this on other boards resulting in much worry for SWIM. The number of APAP OD's is staggering much mor eattention should be payed in the medical community of the dangers of this, because for the most part the public is not educated in this matter.

SWIM has seen people say they have eaten 6, 8, 10 even 14 grams of APAP in a single dosage, that is terrifying!

SWIM used to take 3000-3500 mg's a day and then drink heavily in the night. SWIM will NEVER make a mistake such as this. Just today a CWE was preformed with quite a bit of hydrocodone and it very satisfied with the results. Potentiating was of course necessary.
The one disappointment was lack of planning when it came to filter the solution. Their was no coffee filters to be found so several layers of paer towels were used.

[Panthers007]

Whatman 1 filter papers, in a variety of diameters, are available over the net. The #1 is quite sufficient for performing a CWE and beats coffee-filters hand's down. Why not go professional if the material is available?

[0utrider]

do you have any more info on that? swim would like to add that to the CWE faq..

[eklypised]

Is it safe for SWIM to take 4000mgs of APAP everyday. Or for a couple of days straight?