Which Cocaine Analouges would most Represent Similar Effects to Cocaine?

[CrakkBakk]

I found this on a paper on the ground:

Drug X has certain effects on different receptors in the brain.
Drug Y works on different receptors then Drug X

An analouge of drug X may work on similar receptors as drug X but will be different none the less. Some of the analouges may even work on completley different receptors!

It is relativley easy for me to look at phenethylamine analouges to determine which would be the most similar to MDMA and choose a RC to match that.

For cocaine, it is harder for me to figure this out.

Off the top of your head, does anyone know which cocaine analouge would produce effects MOST similar, (or better perhaps) then cocaine?

All the following info is from wikipedia.

Cocaine is called a dopamine reuptake inhibiter, a serotonin reuptake inhibiter, and a noradrenaline reuptake inhibiter. Cocaine blocks, or inhibits, the reuptake of dopamine via the dopamine transporter protein causing massive amounts of it to be stored in the synaptic cleft. Cocaine also blocks the reuptake of the serotonic 5HT3 receptors. Cocaine also works on NMDA receptors (same receptors as PCP/ketamine??) and D1 (dopamine 1 receptor).

http://en.wikipedia.org/wiki/2%CE%B2...hyl%29-tropane

This compound is apparently 500-800times more potent then cocaine at dopamine and serotonin centers..


Anti depressents are known to work on dopamine and seratonin but do not get you high. Some articels I read that wiki linked too seemed to imply that certain cocaine analouges won't get you high because they will act like anti depressents.

Any thoughts?