Dxm Xtc

[allinuse]

Hey, I remember seeing in the past ppl's posts in which they have said that DXM can reduce tolerance to MDMA. SWIM was curious, how does this what, like what's the science behind it, and if so, is it the sort of thing were SWIM takes DXM the day before MDMA or like sometime during the week leading up to the event. SWIM doesn't have much of a tolerance, but he has started taking pills more than he used to and wanted to know.

[RaverHippie]

It doesn't reduce tolerance so much as it potentiates the mdma.

[radiometer]

MDMA and DXM are expressly contraindicated, due to the fact the taking a drug which strongly inhibits CYP2D6 is a high risk factor with MDMA, as well as other reasons.

There have been a large number medical emergencies reported from this combination. In fact, this combination is basically the reason for the existence of the harm-reduction group DanceSafe.

http://www.maps.org/news-letters/v09n4/09447sfe.html

The prevalence of DXM tablets on the ecstasy market is of particular concern. DXM is a cough suppressant that in high doses is a dissociative similar to ketamine. We had been receiving numerous emails from ecstasy users reporting extremely unpleasant experiences from supposed ecstasy tablets, particularly a brand known as "green triangles" which had surfaced everywhere around the country. Users who had taken these pills reported nausea, delerium, itchy skin, loss of motor control, and audio and visual hallucinations. Effects were reported by some to have lasted 36 hours or longer, particularly in users who had taken multiple pills. Some users reported that they or their friends had been hospitalized after taking these pills, and the Dancesafe volunteers personally witnessed over a dozen medical emergencies requiring hospitalization in Oakland where users had consumed the green triangles.

The rumor going around was that these pills contained heroin and/or mescaline. After testing five of these pills at the laboratory we discovered that they contained high doses of DXM (averaging 127mg per pill). We immediately posted warnings on our website and through various rave email lists. While relatively safe in the proper dosage and environment, an overdose of DXM in a rave setting, particularly by someone not expecting the drug, can be dangerous. Furthermore, DXM is contraindicated with MDMA. It is a both a serotonin releaser and a reuptake inhibitor, as well as being metabolized by the same liver enzyme as MDMA, thus preventing the proper breakdown of MDMA. Furthermore, DXM inhibits perspiration, elevating body temperature. Combining DXM and MDMA, therefore, significantly increases ones chance of "serotonin syndrome," a rare but potentially fatal condition. We witnessed a number of serotonin syndrome occurrences involving accidental DXM/MDMA combinations, and there are a number of documented cases of serotonin syndrome resulting from people who had taken DXM-containing cough syrup while on MAOIs or SSRIs, two types of serotonin-affecting anti-depressants.

Further Info

Reputation Comments on this post:

thanks, beat me to it

[allinuse]

Whoa, sounds like perhaps it wouldn't be the smartest idea. Thanks for the info.