What are these?

[t3rror]

I would like to to some research on some subtituted phenylalanines. The 3 chemicals I am interested in are

1. alpha-methyl-phenylalanine
2. alpha-methyl-3,4-methylenedioxyphenylalanine
3. 4-bromo-2,5-dimethoxyphenylalanine

Can anyone with the chem drawing program draw the structures of these chemicals. Thanks for your time

[trptamene]

Will draw these out later this afternoon, but am interested in the research.

Do phenylalanines show activity or is one just interested in the synthetic precursor?

[trptamene]

[t3rror]

Thanks trptamene...

I cant find much in the way of anything about substituted phenyalanines on google. It would be interesting to see what effects these unnatural amino acids would have on say a person suffering depression or similar symtoms or if CNS effects are present. Also what effects these would have in combination with other supplements like ephedrine. It could be nothing, but on a whim, im trying to satisfy my curiosity. Thanks again

[Paracelsus]

Since nobody knows better (these are unresearched compounds), the most logical speculations would be that they undergo decarboxylation like other amino acids do. If decarboxylation is the only significant route of metabolism, this would mean that these compounds are a sort of extended-release version of the compound lacking the carboxyl (MDA, 2C-B, amphetamine). Brain penetration would probably be increased. I don't see anything of particular interest in substituted phenylalanines, but who knows?

[Zaprenz]

SWIM is shocked no other SWimmer has mentioned alpha-methyl-p-tyrosine and how it works quite the opposite, certainly the logical assumption that they would be more active, get past BBB or breakdown/slow release is not well founded.

Useful reading:

http://www.cognitiveliberty.org/shul...rchive/dmt.htm

http://en.wikipedia.org/wiki/AMPT

In fact of all research chemicals - SWIZ would be more worried about any amino acid. So many bodily functions are dependant on them.

[Paracelsus]

I just remembered p-chlorophenylalanine, which is a potent and irreversible inhibitor of tryptophan hydroxylase, an enzyme that catalyzes hydroxylation of tryptophan into 5-hydroxytryptophan. p-Cl-Phe administration deprives the body of serotonin by interfering with this essential step, inducing depression (in rodents, at least).

I am a bit confused about Shulgin's statement about the alpha-carboxyl derivatives of tryptamines not entering the brain. Many amino acids enter the brain, while their amine homologues do not (e.g. 5-HTP vs. serotonin, levodopa vs. dopamine, etc.). This is, for example, the rationale behind levodopa+carbidopa treatment of Parkinson's. The objective of this medication is to increase brain dopamine levels. Dopamine itself does not enter the brain and is thus useless per se. Levodopa does enter the brain, and is decarboxylated by aromatic amino acid decarboxylase (AAAD) into dopamine. To potentiate levodopa-induced brain dopamine increase, carbidopa is used. Carbidopa inhibits AAAD but does not enter the brain (so it only inhibits peripheral AAAD and not brain AAAD). Thus, most levodopa enters the brain, where it is metabolized into the desired dopamine, while carbidopa prevents it from being wasted by peripheral conversion to dopamine. Am I missing something?

[t3rror]

Can anyone help me in correctly indentifying this chemical. It looks similar to a chemical structure posted by research chem moderator trptamene. Is this chemical alpha-methyl-3,4-methylenedioxyphenylalanine?

[t3rror]

here is the structure

[Paracelsus]

That is 3,4-methylenedioxyphenylalanine.

[0utrider]

Hi i found some chemicasl from several vendors, but am not sure what they are. The are typed in a strange way, so if i look em up at DF i just cant find anything sufficient..

would be nice if SWIY could give me more "common" names for these

2- methyl amino-1-(3,4-methylene dioxy phenyl) propan-1-one

Methylenedioxypyrovalerone

[Winta]

2- methyl amino-1-(3,4-methylene dioxy phenyl) propan-1-one Is Methylone
Methylenedioxypyrovalerone is MDPV (MDPK, Pyrro)

Try, google :P