Combinations - how is this possible - dxm, yohimbine, st john's wort

[snapper]

From erowid :
Not What I Expected At All
DXM, Yohimbe & St. John's Wort
by Itchy

DOSE: 450 mg oral Yohimbe (daily)
300 mg oral St. John's Wort (daily)
885 mg oral DXM

BODY WEIGHT: 300 lb



I did some research on dxm prior to trying it, but did not consider possible drug interactions. Hence, I took yohimbe and St. John's wort in my usual daily amounts in the afternoon. Around 8:30 P.M. I took the dxm. Setting is my apartment; I am alone.

t+1 hour- I start to feel a slight buzz.

t+1.5 hours- Intensity increases; as it does so my face begins to itch. Itch spreads to chest and back; I look in the mirror and see a bright crimson rash on most of my upper body. I feel slightly feverish. I have diarrhea, and shit four times in the next hour. My heartbeat is somewhat erratic.

t+2 hours- I feel very manic; I am filled with energy. This is not what I expected at all; the experience resembles more than anything else my few cocaine experiences. It would even be pleasant if it weren't for the diarrhea and rash.

t+2.5-3 hours- The diarrhea stops, thank God. The rash also subsides, though I have an occasional itch for hours to come. Sadly, the manic euphoria dies down as well. I am left with a feeling of peace and contentment. I don't feel high anymore, exactly, I just feel good. Happy and relaxed.

Conclusion: This was not what I expected at all. I felt nothing remotely psychedelic or even dissociative. Probably this was a result of unforeseen drug interaction. Overall, despite some unfortunate and even frightening symptoms early in the experience, I enjoyed myself. I will probably experiment further with dxm, but in the future I will use more care.

Exp Year: 2008 ID: 71084
Gender: Male
Added: May 11, 2008

SWIM has never even pushed the DXM dose that high, and it seems that it would be impossible not to feel any effects from over 800mg, even at 300lbs. Any thoughts as to why ? Yohimbine is amild MAOI and an alpha 2 antagonist, neither would normally be expected to inhibit DXM. St John's wort is a mild SSRI, which could inhibit the effects somewhat but would more likely help induce serotonin syndrome. Any thoughts?

[Graduisic]

sounds like this person was a novice diving into too high of a dose and their body had a histamine reaction to DXM. the serotogenic effects from st johns wort and the mild MAO inhibitor from the yohimbine combined with having a shitty (both figuratively and literally) experience would most likely kill any sort of expected bodily effects.

Also interesting to note, in SWIM's experiences tripping with others, the ones who get the robo-itch or have a similar histamine reaction do not find DXM to be an enjoyable experience at higher plateaus; lower dosages can produce some euphoria, but nothing near the profound, amazing effects SWIM feels he gets from high plateau doses (he does not have a histamine reaction to DXM)

[snapper]

It's not the histamine reaction -SWIM gets that. It's that the DXM wore off after 2 hours. SWIM has never even pushed the dose that high. 600mg was already almost too much and lasted a very long time. How could 885 mg wear off after 2hours ?

[kaczynski]

Large doses of DXM will almost inevitably provide the user with a healthy serving of the shits before their trip is done.

[AquafinaOrbit]

SWIM has taken doses over 1000MG and had no stomach issues at all. 2 hours is strange, SWIM is much smaller person 140LB but his trips go for hours until I finally crash. Forgetting the size difference though the medicine is designed to work for 6 hours, so one of the other chemicals must of altered that.

[snapper]

SWIM's trips have lasted at least 12hours, with a 1day afterglow.

[Graduisic]

sounds like a slight enzyme deficiency

[dexajuanohol]

It's not an enzyme deficiency, but an overactive enzyme. St. John's Wort induces the action of cytochrome P450 3A4, which is involved in the metabolism of a huge number of pharmaceuticals, DXM being one of them. SWIM has been affected a couple of ways by this. Once, on an empty stomach, he took one 300 mg capsule of St. John's, and it only took 30 minutes for him to feel the effects of DXM polistirex, which usually takes at least 2 hours. More recently, he took what should have been a second plateau dose of DXM polistirex with 2 capsules of St. John's Wort, and he barely felt any effects at all. So it seems to him that St. John's Wort can either quicken your trip, or completely ruin it. Hope this was helpful.

Reputation Comments on this post:

Correct, good info. All depends on which natural enzymes the person has too...

[fiveleggedrat]

None of these should be mixed, to note; everything here screams "danger!".

[Euthanatos93420]

Sounds exactly like Swim's average Dex ISHO. Take WGFJ to potentiate that and get the most bang for your buck (or chemicals ingested). i.e. you might be able to step down the dose. Take a 25mg benedryl or if it was really severe maybe two. this will counter both the rash and acually act as a mild sedetive to the mania in Swim's experience.

As far as the shits...switch to zicam. It's mostly the propelene glycol and other inactive breaking down in your gut (and breaking down your gut). Zicam, being highly concentrated (24mg/ml vs 3mg/ml of robo) contains less per dosage ingested. Swim has found that all dex products except Zicam Cough max spray (.55 w/o alchohol ~400mg/bottle) including Vicks, CCCs (In his ignorant youth), Robitussin, Robogels, and comparable store brand varieties cause diarrhea. It's the ZICAMERAL MINDSET!!!! hahaha! P

Furthermore, can swiy check the package? Perhaps if the DXM was expired then it would have broken down and swiy would have recieved less DXM and had an unbalanced trip from potential toxic chemicals in the biodegraded DXM? Although Swim is inclined to the that perhaps the SJW may have been responsible for the shortness and intensity of the experience. In swim's experience anything stimulating tends to cause similar experiences. Swim got his tongue pierced while dexin' once and thereafter the drunkeness of the trip cleared up upon vomiting (common with piercings though swim was well enough into the trip not to lose any dex) and he settled into a state of something like a superbright afterglow. The 5-htp contributed to this as well, as a pre-cursor to seritonin swim can see how swiy's description feels similar to swim's to swim as SJW is an Seratonin reuptake inhibitor.

Swim cannot comment on MAOI's as he has ALWAYS smoked (Tobacco-an MAOI) while dexin' without exception and never tested it against any other MAOIs (Nor is he inclined to).

[snapper]

DXM is pretty stable. SWIM took 30 mg of pure powder that is 12 years old for a cough (no otc remedy available) a while back and it worked very well.

[Frond]

Yohimbe = weak MAOI. DXM + MAOI = possible serotonin syndrome = possible death. Throwing St. John's Wort into it, which has mild SSRI properties, is only going to make serotonin syndrome that much more likely.

Things like this are really dumb and should never be done. People always need to read up on whatever drugs they intend to ingest, and every bit of literature on DXM, starting with the excellent FAQ by William White, will mention the absolute necessity to stay away from MAOIs. SSRI + MAOI = not an especially good idea either.

Basically, I expect that whoever posted that on Erowid either wisened up and never did it again, or is now in the Darwin awards. Because mixing these drugs is like playing with a loaded gun. It's just a matter of time.

[fnord]

Grandma once dosed and felt no body buzz at all,she has no idea why and she dosed 800mg then another 800mg a few hours later. the only thing she had in her system that day was a packet of mixed vitamins,the kind you get in a bag at gas stations with 7-8 different pills in it.

[Panthers007]

Never heard of "...a packet of mixed vitamins,the kind you get in a bag at gas stations..." And I sure wouldn't trust them! That's like buying a stereo from the milkman. The only vitamins I buy come in large bottles with legit company names on them. But that's very strange.

My best find at a gas-station was a dispenser of Spiro Agnew (vice-president under Nixon) condoms.