Drug info - Lucigenol

[Winta]

Please post info about Lucigenol here.

Please post information about:

• Names / synonyms
• Molecule
• Dose
• Duration
• Legal status
• Reported incidents/fatalities
• Since when has this research chemical been available
• Stability
• if this compound detectable in drug tests & for how long
• Reaction to Marquis or other tests.
• Tolerance & Cross-tolerance
• Appearance (visual, smell, taste, crystal/powder)
• Forms commonly available & routes used with each.
• Common Effects: Main (During & after), Side (long & short term)
• Any known drug & food interactions

Names: Lucigenol, L2D
IUPAC: (R)-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indol-4-ol

Experiences with Lucigenol should be discussed here:
Experiences with Lucigenol

Reputation Comments on this post:

Thanks for bringing this substance to attention and for your info on it.

[Samadhi]

INFO

5-ht2a receptor agonist
(R) isomer is more potent
Binding affinity for 5-HT2A receptor is 13 +/- 2 nM (Ki [125I]DOI).

bear with swim, his chemistry is not too good, It seems that this chemical is not an analoug of LSD as it doesn't have any C or D rings like LSD. It looks like a 5-methoxylated chemical because of it's structure.

(Swim looked this up all morning please correct and explain to swim if wrong but)

the alpha methyl is extended and attached to an amine with one more methyl group making it a 5 position... but apparently there is an 4-ho positioned one of lucigenol... this gets more and more confusing.

This is not swims area of expertise but this chemical really caught swims ears and eyes.

Dose is reported as so
0.5mg active, 1.0-1.5mg seem to be psychedelic doses.

Duration
heard eight to six ours.

Effects (still not too documented)
OEV/CEV
sedating feeling
Anxiety swim has heard is high with this one.


Overall this is all swim could find or think of. what a goofy chemical.

Reputation Comments on this post:

Thanks,grandma would love some more info on this..

[Alfa]

This looks very interesting on first sight. Please add more information.

[trptamene]

AMT is chiral. Is the R form the more potent in that as well?

[Samadhi]

No clue on AMT, but 5-MeO-AMT is not too active in it's R version. Like i said this chemical is goofy.

[Panthers007]

Need a stereo-chemical workup to figure which/how R and S would interact en vivo. This baby is fresh out of the flask.

I'd council all SWIM's out there to approach with caution and respect. Real slow boy's & girls. It's not a horse race.

Reputation Comments on this post:

Truth

[Samadhi]

Swim has found this chemical floating in the wind it is not cheap and it is a custom synthesis-type chemical. agreed with panthers, use extreme caution and start very very low. this one has no "qualitative comments" so far so it is virtually untested.

[trptamene]

Crazy this is already seen as an RC, that is risky biz. Wonder how long till the n-benzyl phen's are seen...

[Panthers007]

I'm waiting for the DoE to start selling 2-CAt.

[Winta]

According to SWIMs source the R isomer should be noticeably more potant.

SWIsamadhi123 seems to be right about the doses.

[fnord]

Winta any update?

[Winta]

SWIM is still working on more info on this one, this is one of hes main priorities atm.´

But there is very little information available.

[Winta]

4 of SWIMs friends tested this in Alcohol the other day, they took 130mg and put into 130ml vodka and then they took 2ml each, none of them got any effects, why could this be exactly? (they had shaken it good, and it look like it did mix into the vodka)

[sweetsweetmary]

Originally Posted by Winta

4 of SWIMs friends tested this in Alcohol the other day, they took 130mg and put into 130ml vodka and then they took 2ml each, none of them got any effects, why could this be exactly? (they had shaken it good, and it look like it did mix into the vodka)

SWim is interested in Hearing about this although SWIM will probably never try in his life time.

[Samadhi]

Originally Posted by Winta

4 of SWIMs friends tested this in Alcohol the other day, they took 130mg and put into 130ml vodka and then they took 2ml each, none of them got any effects, why could this be exactly? (they had shaken it good, and it look like it did mix into the vodka)

Maybe it needs to be taken with an MAOI or IV'd for some reason. Shulgin suggested that Bromo-Dragonfly was much better IV'd than taken orally, maybe these two are on the same page for that one? (yes i know that Bromo-Dragonfly is a difuran ring chemical not a 5-methoxylated-type like Lucigenol seems to be)

[Winta]

But another of SWIMs friends tryed this the other day only .5mg and he got effect.

SWIM thought that maybe it was becouse of the alcohol?

[dr_haldol]

Fascinating how low the active dose is...

@winta
Alcohol? Possibly yes.
SWIM is absolutely unable to understand how someone who is trying an absolutely new drug can even come to the idea of combining it with any other drugs? If you know the characteristics of the new drug, sure, go ahead; but without any in vivo knowledge?

Be warned that fatal damage to your body doesn't have to be dose-related. And, as already known, enantiomers can differ (heavily differ) in the way they're acting in your body...

[Winta]

Well, SWIM beleive that SWIMS friend only put it in alcohol to have an easyer way of dosing it (They had a way of messuring ML but not MG)

2ml vodka is not enough to get much effect of that.

[dr_haldol]

Sorry, I must have overread that 2 mL part.

[fnord]

Originally Posted by Winta

Well, SWIM beleive that SWIMS friend only put it in alcohol to have an easyer way of dosing it (They had a way of messuring ML but not MG)

2ml vodka is not enough to get much effect of that.

If there was no scale how did the other test subject know how much he was taking?

How is this compund being stored?

Was there any difference in dosing method? for example the people that
took it in alcohol im asuming they just let it absorb in there mouth correct?

How did the fellow that got effects dose?
What kind of effects did he get? Were these effects mild or were they more noticible?

Was bloodpresure/pulse taken during this experiment?

Are these 5 people the first known people to dose this?

Reputation Comments on this post:

important questions

[Winta]

The first of SWIMs friends who tested this material borrowed SWIMs weight (0.1mg) and the other only had one that went as low as 10mg.

SWIM believe hes friends who tested it where very persistent on keeping the material as cold as possible. (Fridge at all times, and kept with a freeze block anytime it was moved.)

SWIM actually believe that they just took the 2ML shot without keeping it in the mouth, and that was properly the problem, he will ask hes friend as soon as possible.

SWIMs friend who got effects, took the compound directly from the weight with hes finger and licked it off. Effects where visible about 20 minutes after. They where like a mild LSD trip he told SWIM.

No, bloodpresure/pulse where not taken, but they did try and feel it if it felt above normal, it didn’t really, but it is hard to tell without the right instruments.

SWIM read about someone who said the dose was 1mg (which is why SWIMs friend started at 0.5mg) but SWIM has no source on this and it was properly a bit risky to start on that dose with a compound like this.

SWIM is going on a week long vacation now, but will return as soon as he get home.

Reputation Comments on this post:

Thanks for the answers.

[fnord]

This chemical was created by nichols right? anyone have his original writeup on it?



Edit:all set on thew addy. Thanks.

[fnord]

Im still looking for more info i would still be quite happy if anyone could post info. Esp. people who have tested either of the isomers of this psylocin analog.

The R- compound had an ED50 of 0.26 micromoles/kg, whereas psilocin had an ED50 of 1.01. Thus, the pyrrolidinyl compound could be estimated to be about five times more potent than psilocin. A guess at corresponding effective human doses would then be from 2-6 mg. Nothing is known about its toxicity, effects, etc.

Reputation Comments on this post:

Thanks for the info!

[trptamene]

Can u ref that baby fnord?

[fnord]

I'm not sure if my source wants to be identified,but this was a private conversation with someone i would trust more then shulgin with info on this particular substance.

Sorry, trust me or not,the decisions up to you, but i can 110% guarantee that the info i have is some of the best info around on this.