PEA (Phenylethylamine) + MAO inhibitor

[poozjurry]

Is PEA and MAO-B inhibitor a effective Drug?

[RaverHippie]

after short (brief) research SWIM was only able to find speculation, no documentation, of psycho activity. SWIM would never want to attempt a bioassay of PEA + MAO-B inhibitor due to the many warnings of interactions of psychoactive chemicals and MAOI's. He wouldn't feel like risking his brain for that one.

[NeuroMD]

Originally Posted by poozjurry

Is PEA and MAO-B inhibitor a effective Drug?

Yes such as combination has been in a few studies. Also deprenyl a proven safe selective MAO-B inhibitor has very few interactions.

PEA by itself is effective in higher doses:


Phenylethylamine experiences


jeremyleinen

”2nd day on this stuff. I took it right before I left for work(1g), and it hit me as I was a couple miles from work. Had me feeling almost buzzed a little bit, highly euphoric, and my sense of everything was heightened. Kinda crazy. That slight weirdness only lasted 30 minutes maybe, and I felt pretty good the rest of the day.”

”So, I only went in to work about an hour early, when I fairly often go in 2 hours early on busy days like today. On top of all my usual stuff, I had to make some cauliflower vichyssoise for this weekend's soup, and a batch of chicken liver mousse for our charcuterie platter. Well, I got pretty busy in the dining room during service, so my boss was helping me plate up and was concerned about product needs, but I told him what all I had backups for and he responded by asking what the hell time I came in today. When I told him i was only in an hour early he was shocked with the amount of work I got done this afternoon- and I have the reputation of being the workhorse of the groupl(I'm sorta like that ox or whatever from "animal farm").

So, yeah, I guess this PEA really does do something for mental accuity. Thought I'd share that with you guys.”

”I've noticed that beyond the enhanced focus, I'm generally much easier going when I'm on this stuff. Which is good, since I'm generally a royal prick in the kitchen.”



RooRooTJ

“Well switched to 2 500 mgs pills twice a day the last 3 days and have noticed some good results but a little side effect as well. I have taken then on an empty stomach and noticed that about 30 minutes after I took them, I got really focused, but a little numb. Almost like I was floating. I am only getting this feeling on my first dose of the day. It is not a bad feeling just a little odd. It goes away after about 15 minutes and then I can notice I am really focused and am on top of things. Noticed a big difference when I was flying this weekend too. It definetly made the airports easier to handle.”




joakman

“Notes from today:
Took the 4 caps before breakfast to see if I would have the same feeling as yesterday. I ate immediately after taking them and about 15 minutes later. The buzzed, all over numbness hit me. I took a quick challenge for myself to see how my body would react. I banged out 6 perfect chin-ups very slowly, (barely could do 1 on a regular day) and had curled 115 lbs (something I would never attempt before, it was left like that in my weight room). I don't know if it gave me some superhuman strength or something, but it was pretty cool.”


Norwegian


“2,000 mg (4 caps) consumed on an empty stomach.

- Definitely an increased euphoric/happy feeling with the added dosage. I was talkative, happy, and 'glowing.' Nothing can bring me down when I'm 'on' PEA, because even if I sense an argument coming, I find myself staying calm about it and instead 'agree to disagree' and present it very gently. It's quite the change for me, because normally I have a hard time avoiding argumentations, or I'll always want to win them, and the fights tend to get out of hand. PEA allows me to enter in to any daily action in a very relaxed and approachable manner. I don't stress about my chores, I simply do them and I feel good about it.

So far, PEA has been a very enjoyable compound to try out. I am looking forward to seeing its effects starting Monday morning, my first day in my cubicle internship.”

“I took 1,500 mg upon waking on an empty stomach, and felt anxiety-free, relaxed, and happy within the hour. That's the most prominent thing I've noticed from the PEA usage thus far; the decrease in anxiety. It's quite remarkable actually, I no longer fear situations I used to - first day at work, interviews, etc - and if a stressful situation arises, I'm able to cope with it without feeling bad or it taking over my mind entirely. I'm also less aggressive, or more correctly, it takes more for my cup to spill over. Since I began taking PEA, I haven't spilt over once actually.”

“5/5 star rating so far. PEA is a feel-good nootropic that keeps my confidence where it's supposed to be at. I've considered doing a 3-4 gram dosage at once to see its effects, but I don't want to run out of this anytime soon, and with those kinds of dosages, the supply won't be long lasting, something I want it to be ..”

“I took an additional 4 caps (2 grams) half an hour before hitting the road driving for an hour. 5 minutes in to my driving, I felt weird sensations on my body; sort of like a body high. Tingling in forarms and legs. Good sensations in my 'area.' Definitely got me wondering how this'd be before a bed-adventure ! After 15 minutes, I swear, I felt as if I was floating on a cloud. Every movement I made felt real 'fluid' for the lack of a better word. I felt GREAT! Awesome mood, I really wanted to tell someone about how I was feeling at the time, but I didn't feel like calling anyone. I just wanted to enjoy my body-high and see how long it lasted. About 40 minutes in, it started fading little by little. Within the hour mark, no more body high, but a mild, relaxing mood.”

“Honestly, I haven't taken anything that could measure up against this .. at least not legally .. PEA puts me in a fantastic and encouraging mood. I am the most approachable guy 'on' PEA, and I always want to talk. I did a tab (ecstacy) as a Junior in high school, and to be completely honest, that's as close to PEA as I could think of.”

Reputation Comments on this post:

Interesting, but please tell us about where the quotes are taken from. Nothing in literature seems to suggest PEA can be...

[0utrider]

to SWIM this doesnt sound too bad but what MAOI was taken? and what dosage?

[NeuroMD]

Originally Posted by outriderx

to SWIM this doesnt sound too bad but what MAOI was taken? and what dosage?

The above experiences were without any MAO inhibitor.

I've used 5-15 mg of Deprenyl (an effective MAO-B inhibitor) with PEA 250-500 mg without problems.

[foxydoe]

Originally Posted by NeuroMD

The above experiences were without any MAO inhibitor.

I've used 5-15 mg of Deprenyl (an effective MAO-B inhibitor) with PEA 250-500 mg without problems.

What were the effects and duration?
This combo has always intrigued me....

[Richard_smoker]

NeuroMD, where are you getting those experiences?? from a forum?...i'm not asking you to incriminate anyone, i'm just curious if those were the exact quotes from real people... to me it kinda looks like advertising copy for some herbal remedy cure-all's... like those ads that promise you to "get more energy and have an increased overall sense of wellbeing!!"

[Boca Bitch]

Originally Posted by RaverHippie

after short (brief) research SWIM was only able to find speculation, no documentation, of psycho activity. SWIM would never want to attempt a bioassay of PEA + MAO-B inhibitor due to the many warnings of interactions of psychoactive chemicals and MAOI's. He wouldn't feel like risking his brain for that one.

MAO-B are safer to take with other drugs than its MAO-A counterpart. This doesn't mean that combining any MAOI with a phenthylamine is an intelligent idea, but it certainly is much less risky.

MAO-As interact with serotonin, and can cause serotonin syndrome (a non-curable life threatening condition) when combined with other triggers of the serotonergic systems. MAO-Bs interact with dopamine, and can still result in fatality if taken in excessive amounts with other stimulants, but is more likely to result in non-fatal hypertensive crisis. In which case, a GABA agonist or antipsychotic should be administered under medical approval, to decrease blood pressure and heart rate.