Progress in the Synthesis of Morphine

Recent Progress in the Synthesis of Morphine Alkaloids
Recent Progres in the Synthesis of Morphine Alkaloids Josef Zezula,a
Tomas Hudlicky
Synlett 2005, No. 3, 388Ð405</font>

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Abstract: Recent accomplishments in the field of total synthesis of
morphine alkaloids are reviewed. Approaches to the skeleton of
morphine are included as are various efforts towards related medicinally
important agents. The literature coverage begins after the
publication of our last update in 2000 and continues mid-way
through 2004.
1 Introduction
2 Total Syntheses of Morphine
2.1 Taber
2.2 Trost
2.3 Ogasawara
3 Approaches to the Morphine Skeleton
3.1 Vollhardt
3.2 Ogasawara
3.3 Cheng
3.4 Passarella
3.5 Hudlicky
3.6 Hudlicky
4 Unnatural Analogs and Mimics
4.1 Rice
4.2 Grauert
4.3 Trost
4.4 Ohno
4.5 Schmidhammer
5 Conclusions and Outlook
Key words: morphine, total synthesis, alkaloids, approaches to
morphine skeleton, morphine analogs and mimics