Combinations - MDPV and Tramadol

[EarlGrayUK]

MDPV is a norepinephrine and dopamine reuptake inhibitor and Tramadol is "believed" to work through modulation of the GABAergic, noradrenergic (norepinephrine again) and serotonergic systems, in addition to its mild agonism of the μ-opioid receptor.

So SWIM thinks there is no risk for serotonin syndrome. Any objections? Anyway, SWIM had that idea that Tramadol could be MDPVs little helper at the end of the show.

In a theoretical scenario, SWIM insufflated 15mg late in the evening with pleasurable results. When the comedown started in the morning, SWIM swallowed 100mg Tramadol. After approx. 15 min, SWIM felt great, MDPV comedown effects were gone or not noticed anymore.

After lying down, SWIM experienced warm waves of euphoria every once in a while and then actually managed to sleep, which even with smaller doses of MDPV was impossible within that timeframe. When SWIM woke up, he still was very well and actually felt like eating despite MDPV, known to make SWIM not eat for 20 hours or more. SWIM still feels good 16 hours after insufflating MDPV and wonders if Tramadol can be used to get the best out of MDPV without some (or maybe most) of the less pleasurable effects.

Does SWIY have any comments or smacks on SWIMs head for being stupid and making up that theoretical scenario?

EarlGrayUK added 1167 Minutes and 17 Seconds later...

Well, SWIM gets the impression that the combination of MDPV and Tramadol is not that interesting for SWIY? SWIM would have loved to hear what others think about it.

[Pino]

Swim shouldn't try stimulant + tramadol. At least on person died on the combination of cocaine and tramadol. It lowers the seizure treshold (tonic-clonic), which mdpv isn't going to heighten.

[Bajeda]

Very dangerous. As Pino mentions, no one should try to mix stimulants with Tramadol. You are asking for a seizure with that combination. It may work a few times, but you never know when your body will react badly to such an unpredictable mixture. Please reconsider this idea. There are files in the archive on Tramadol's tendency to lower the seizure threshold, plus some terrible experience reports on erowid that show what can happen when you mix stimulants with tramadol (seizure, blackout, waking up at the hospital with tubes and IVs all over you, not fun). MDPV is risky enough given how little is known about it, you really don't need to throw in another substance that could antagonize your body and mind in combination with other substances. I can't see how the risk is worth it.

[EarlGrayUK]

Thanks, this are the kind of answers SWIM was hoping to get.