Originally Posted by paradies
You can use regular Acetone that youcan buy at a hardware store. There are different concentrations of Acetone, but it doesn't really matter. Here is an extraction method, using acetone.
How do I extract Salvia divinorum leaf, should it be whole, crushed or powdered?
When I first started extracting Salvia divinorum leaf with Acetone I found that it didn't seem to make any difference whether the leaf was whole, crushed or even finely powdered, regardless I found that salvinorin was extracted from leaf from whole to finely powdered with the same efficiency. Since Acetone worked so well with whole or crushed leaf my assumption was that most, if not all of the salvinorin was coating the outside of the leaf instead of inside the leaf, either that, or Acetone was somehow able to efficiently draw the salvinorin out of the interior leaf membranes. Daniel Siebert recently published a paper confirming my belief that salvinorin is concentrated on the outside of the leaf, because of this it isn't necessary to powder the leaf to be able to efficiently extract salvinorin using any solvent which salvinorin can be dissolved into. When I extract large amounts of dried leaf with Acetone I usually just hand crush the leaf as fine as I can and then add enough solvent to completely cover the leaf with an extra couple of inches of solvent over the top of the leaf. Average potency Salvia leaf contains close to 2.5 mg of salvinorin per gram of leaf, high potency Salvia has been reported to be as high as 4 mg salvinorin per gram of leaf (although I have my doubts, it might be true). Salvinorin solubility in Acetone at 27 degrees C. has been reported to hold 23 mg per ml of fluid, Isopropanol .74 mg, Ethanol 1.28 mg per ml of fluid. On this basis 100 grams of Salvia leaf should only need a few ml of Acetone to extract the salvinorin, but that amount of fluid is far too little to be able to completely cover finely crushed leaf! If the leaf is finely powdered to the consistency of flour you might want to calculate the amount of Salvinorin in the weight of powdered leaf to determine the amount of fluid needed but otherwise I wouldn’t even worry about it, especially if extracting your batch of leaf two or three times over as I recommend anyway, resulting in the use of many times over the amount of solvent needed to hold the amount of salvinorin contained in the leaf. Although Salvia divinorum leaf does not require fine powdering to extract it, if you powder your leaf you can use far less solvent to extract the amount of salvinorin contained in the leaf but to be safe I like to use three or more times the amount technically required, especially when extracting leaf with either Ethanol or Isopropanol alcohol which salvinorin is far less soluble to compared to Acetone. Alcohol extractions will yield just as much salvinorin as Acetone extractions but always be generous with the amount of solvent needed when using either Ethanol or Isopropanol which have far lower solubility’s to salvinorin than Acetone, requiring more fluid and longer extraction periods.
Is there a simple way to make enhanced leaf?
The following is as simple as it gets to make a gram of 5X enhanced leaf:
1. Pour enough room temperature Acetone into a glass container to completely cover six grams of finely crushed Salvia divinorum leaf and stir for three minutes or longer. (To make sure you have extracted most of the salvinorin pour in some more Acetone and stir for a second time for three minutes and add it to the Acetone in step 2 below, a third time through for just one minute will assure you have removed most if not all of the salvinorin if using Acetone but also increases the amount of waxy lipids extracted making a harsher smoke.)
2. Pour Acetone off of the extracted leaf into a glass bowl containing one gram of un-extracted finely crushed leaf and evaporate all Acetone while leaf is present in it, stirring while the last of the solvent evaportes out. Be sure to mop up all of the residues from the sides of the container with the leaf as the last of the solvent evaporates out.
3. Once every hint of solvent smell is gone from the leaf, Wha-la! Enhanced leaf. Store out of the light, cold storage is better than warm, especially a freezer to assure many years of full potency.
Note: I like to use an extra amount of Salvia leaf to make up for possible extraction inefficiencies. In this simple method six grams of leaf are being extracted and placed back on one gram to make 5X leaf. Since a total of six grams is being extracted to place back onto one gram of leaf the total amount of leaf used is 7 grams to make one gram of 5x which should be every bit as potent as standardized 5x leaf, more than likely closer to 6x. Want to make something stronger using this method? Not recommended because of the increased amount of waxy lipid compounds placed back onto leaf in higher concentrations any more than a ratio of 6 to 1 is about as high as you can go without ending up with a very gummy and harsh burning leaf which produces too much smoke for most people to hack.
I want to make my own low smoke extra salvinorin infused standardized leaf, how can I do that?
This is a brief summary of the lengthy extraction write below it without the water wash of the dried extract (following the Naphtha washes) or the extra purification process of using 99% Isopropanol and without the purity confirmation step of using Acetone at the end. This kitchen chemist route of extracting and refining salvinorin is a reasonable method of making an approximated standardized leaf but unless extreme care is taken to assure the tannin is removed from the extract is fairly difficult to achieve salvinorin at a purity of higher than 90% which is required to make enhanced leaf which is close enough to true standardized leaf to be considered an approximate equal. True standardization of enhanced Salvia divinorum leaf requires knowing the exact purity of the salvinorin being used, extracting leaf to produce 80% to 90% pure salvinorin (with experience) is fairly easy to produce using the methods outlined below. High purity, up to 98% and more can also be produced but unless you have a real need for high purity salvinorin it is not worth the extra time and expense when you can make up for a lower impurity by just using more extract to make enhanced leaf which is every bit as potent as a true standardized leaf by just over measuring 10% (or what ever), but you have to have to know how impure your extract is to be able to estimate how much more is needed requiring HPLC analysis of a few of your extractions and then enough experience extracting Salvia leaf to be able to produce the same potency each time. All of this said, once you have these techniques down well enough you don't need to standardize leaf, a rough approximation through extracting salvinorin from a given amount of leaf which is then deposited on a given fractional amount of leaf plus 15% is close enough, if not more than enough and far less expensive than going to the trouble of having extract tested on a batch per batch basis which can cost over one hundred dollars a shot. You can't claim a true standardization, but at the same time your leaf can be equal to or more potent than a true standardized leaf. When most people buy "standardized" all they are after is a guarantee of minimum potency without worrying the leaf is too potent either, so you don't want to put too much salvinorin back on the leaf. Want to know a secret? Most of the smaller vendors who make their own extracts and calling their product "standardized" leaf are technically incorrect, they are only approximating the amount but this doesn't mean their leaf isn't very close or equal to a true standardized product. Of course, the small vendor making their own standardized leaf could be telling the truth if they are buying their salvinorin from someone who has the skills and equipment to guarantee a purity, but some vendors are also claiming they do so when they are really extracting and refining their own at a tenth or less the cost they would have to pay if purchasing their salvinorin from a lab.
Warning: Do not evaporate Acetone in closed areas (inside your house or garage). Beware of static or electrical spark, open flame (water heater pilot light) or red hot surfaces which WILL ignite vapors from the fluid which can result in the destruction of your and others homes, permanent disfigurement and worse... death. Sounds overly stated? It isn't.
Edited by: paradies
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24-04-2008, 20:47
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