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Old 24-04-2008, 12:46
soma soma is offline
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Suboxone (buprenorphine/naloxone) for opiate overdose?

SWIM was thinking earlier, he sure does wish he had some Narcan (naloxone) around in case he had an opiate overdose. He could get a trip sitter to administer it in the event he took on a risky experiment. He was wondering where he might find this, and realized he already had some laying about! ... In the form of Suboxone (buprenorphine/naloxone). He was wondering, in the event of an opiate overdose, would IV-ing a Suboxone (8mg bupe/2mg naloxone) effectively reverse it? SWIM knows that you'd be adding a small amount of an agonist/antagonist that may cause a small increase in CNS depression, but then the naloxone would activate due to the IV administration, and reverse a large portion of the opiate agonism. He is curious if this has ever been done, because it sounds like a promising source for life-saving naloxone thats available on the street for many SWIMers. For this SWIM, if he has overdosed anyway, 8mg of bupe is fairly negligable, especially if the majority of the CNS depression is effectively negated by the naloxone.

Thoughts? Dreams? Aspirations?

..Jk, but seriously, what do you think?
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