Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature.

[trptamene]

A new entry has been added to Drugs Archive

Description:
Epidemiological studies show that the use of club drugs is on the rise. Furthermore, the last few decades have seen a rise in patterns of
polydrug use. One of the combinations frequently used is ecstasy (MDMA) with gammahydroxybutyrate (GHB). For effective
prevention it is important to be aware of this phenomenon and of the pharmacology of these drugs. The effects of the combination
extend to different neurotransmitter systems, including serotonin, dopamine and noradrenaline. Studies investigating the effects of
combinations of psychoactive substances are limited. In this review we describe the subjective effects of the MDMA/GHB
combination. Furthermore, we review the individual actions of MDMA on serotonin, dopamine and noradrenaline systems. In
addition, actions of GHB on these systems are discussed as a possible pharmacological basis for the interaction of both drugs. It is
postulated thatGHBattenuates the unpleasant or dysphoric effects ofMDMAby its effect on the central dopaminergic system. [Uys
JDK, Niesink RJM. Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA,
ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature. Drug Alcohol Rev 2005;24:359 – 368]

To check it out, rate it or add comments, visit Pharmacological aspects of the combined use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and gamma-hydroxybutyric acid (GHB): a review of the literature.
The comments you make there will appear in the posts below.

Reputation Comments on this post:

thanks for the report

[radiometer]

It is postulated that GHB attenuates the unpleasant or dysphoric effects of MDMA by its effect on the central dopaminergic system.

Of course there is already vast anecdotal experiential evidence on this point.