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Anyone know how long tolerance to opiates typically lasts?
For SWIM, 20-25mg does almost no pain relief and gives little high (body only, too). He thinks this is likely due to methadone use in the past couple months (needs at least 40-50mg for a moderate high). Yesterday he took four 5/500mg Vicodin (typical M357s), and today SWIM tried 5 to see if he could get anything. Unfortunately, he's experienced almost nothing; slight body high, but that's it. Even though this is occurring, it could be possible that SWIM's not feeling it because he's had some migraines almost all throughout the day for the last week. The Vicodin doesn't do anything for that, either. So, yeah... Please and thank you
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