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  #1  
Old 15-04-2008, 16:10
zera Gold member zera is offline
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Using Loperamide to Enhance the Endorphin (Runner's) High

So we all know that strenuous exercise releases endorphins, or the body's natural opiates. Swim loves the feeling he gets after a hard workout session, walking home he always feels very pleasant and warm.

One thing he was considering was using OTC/legal/non-psychoactive loperamide (sold under the brand name Immodium) to enhance the high. Before working out he would take the stuff, then this would saturate the opiate receptors in the gut (but of course have no effect on the brain since it can't cross the blood-brain barrier). But more saturated receptors in the gut also means that once the endorphins come out to play more of them will head to the brain and the endorphin high will feel stronger.

Any opinions or experiences with this? Swims only concern is that taking an anti-diarrheal before strenuous exercise might be a little unpleasant...
  #2  
Old 16-04-2008, 01:42
Sportsguy86 Sportsguy86 is offline
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Re: Using Loperamide to Enhance the Endorphin (Runner's) High

Immodium is simply anti-diarrhea. As you said it doesnt cross the BBB. Take it to get high, and not only won't you get high but you'll end up constipated for 2 weeks. There's a reason why its OTC!!

I can't believe how sad our society is getting. "I want to get high man! Yea! Let's go run 5 miles and snort Immodium!!"

Save yourself the embarassment and if youre looking for a real opiate high just pop a couple oxy's or something. That will get you very high, and no, you won't end up some addict bum on the street. You'll be fine.

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  #3  
Old 16-04-2008, 05:21
OhCasey OhCasey is offline
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Re: Using Loperamide to Enhance the Endorphin (Runner's) High

Quote:
Originally Posted by Sportsguy86 View Post
Save yourself the embarassment and if youre looking for a real opiate high just pop a couple oxy's or something. That will get you very high, and no, you won't end up some addict bum on the street. You'll be fine.
Thats not the best of advice. I'm sure he knows that Loperamide doesnt cross the BBB, hes just suggesting something if you dont like it dont read it. I've actually read reports of people who feel that when they use loperamide in high enough doses it breaks through. My own experience with it make me feel that the effects of it arent fully understood. I've never taken it and felt euphoria but i have taken it while in withdrawals and it made me tired and relieved some of my aches & pains, which shouldnt happen unless it reaches my CNS. Ive read reports on the internet of good amount of people saying they can eliminate withdrawals while using loperamide. On this very board someone mentioned a early study of it that determined it was addictive. That said i dont know if using Loperamide and running will give someone more euphoria then just running cause im not sure if endorphins created by running travel to the gut. Now that might make other opiates stronger if the loperamide is taken first and allows more of ones chosen drug to skip the receptors in the gut because of the loperamide already binding to those receptors.
  #4  
Old 17-04-2008, 18:01
gotxp gotxp is offline
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Re: Using Loperamide to Enhance the Endorphin (Runner's) High

yeah I understand what he is suggesting.. actually kinda interesting... but, im sure the body would naturally down regulate... however, as an initial test... interesting suggestion... post back results
  #5  
Old 24-04-2008, 16:19
Psych0nautPlatinum member Psych0naut is offline
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Re: Using Loperamide to Enhance the Endorphin (Runner's) High

Quote:
Originally Posted by Sportsguy86 View Post
Immodium is simply anti-diarrhea. As you said it doesnt cross the BBB. Take it to get high, and not only won't you get high but you'll end up constipated for 2 weeks. There's a reason why its OTC!!

I can't believe how sad our society is getting. "I want to get high man! Yea! Let's go run 5 miles and snort Immodium!!"

Save yourself the embarassment and if youre looking for a real opiate high just pop a couple oxy's or something. That will get you very high, and no, you won't end up some addict bum on the street. You'll be fine.
You clearly didn't take the time to read the OP's post, but instead were a bit too quick to launch away your reply. If you read the OP's post properly, you would have noticed the OP doesn't want to get high off of loperamide, but wants to saturate the opioid receptors in his gut so the endegenous endorphine released after his exercise would be forced into the brain, instead of getting wasted by binding to the receptors in his gut, this way using the endegenous endorpine more efficiently by forcing it to the receptors where it will actually cause pleasant effects(the brain) instead of letting a part of it flow to the gut(where it's wasted). Next time, read someone's post before jumping to conlusions.

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Tags
endorphins, hydrochloride, immodium, imodium, loperamid, loperamide, lopermide, paroxetine, snorting, snorting loperamide

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