Side effects - Cause of bad reaction?

[staples]

Originally Posted by OhCasey

You dont mean mostly do you? Cause im pretty sure the delayed absorption is do to Microtrol. Adderall IR contains the same amount of various amphetamine salts. One thing ive noticed about crushing XR is that the effects wear off alot faster. If i take an adderall xr after 2 pm i cant sleep but if i crush it i can take it at 4 and be tired by 10. Only time will tell if crushing it actually defeats microtrol but if i had to bet on it id bet it does.

Surely you must not mean you, yourself, do this. Microtrol is supposed to release a second dosage after 4 hours, but the effectiveness over the entire period may be due to the fact that the first release is still affecting the person, so sudden change in concentrations of these two salta may be the only goal of Microtrol.

Also, the placebo effect can be powerful...

Edit: the first part sounds a little too obvious, but I mean as opposed to the gradual change in concentration from taking a second IR of equivalent dose at that time; This may help explain why the same dosage are available, as opposed to twice the amount for the XR form, and this fact at least suggests that not all the delayed release is due to microtrol alone.

Reputation Comments on this post:

one of many great posts in this thread.

[OhCasey]

Originally Posted by staples

Surely you must not mean you, yourself, do this. Microtrol is supposed to release a second dosage after 4 hours, but the effectiveness over the entire period may be due to the fact that the first release is still affecting the person, so sudden change in concentrations of these two salta may be the only goal of Microtrol.

Also, the placebo effect can be powerful...

Edit: the first part sounds a little too obvious, but I mean as opposed to the gradual change in concentration from taking a second IR of equivalent dose at that time; This may help explain why the same dosage are available, as opposed to twice the amount for the XR form, and this fact at least suggests that not all the delayed release is due to microtrol alone.

Ya sorry about that i meant swim. Swim experiences no placebo.

[jazzmetalguitar]

It is wholly hard to say since no information on Microtrol is available to us, the public, however, from personal experience SWIM thinks that it is in fact two doses of the four-fold salts delayed with the Microtrol. This is superior to IR because one doesn't have to remember to redose and the serum levels stay more consistent. All in all, this still means the delayed breakdowns of the salts are responsible for most of the duration in SWIMs opinion. What SWIM wishes he could find was how each salt was broken down to give better explanation in physiological terms.

[staples]

Originally Posted by jazzmetalguitar

It is wholly hard to say since no information on Microtrol is available to us, the public, however, from personal experience SWIM thinks that it is in fact two doses of the four-fold salts delayed with the Microtrol. This is superior to IR because one doesn't have to remember to redose and the serum levels stay more consistent. All in all, this still means the delayed breakdowns of the salts are responsible for most of the duration in SWIMs opinion. What SWIM wishes he could find was how each salt was broken down to give better explanation in physiological terms.

Well hold on, we know microtrol is part of the technology behind XR, we just don't know the specifics on how it works. It may be that it takes advantage of the specific pharmacokinetics of the different salt, I'm sure they had to at least take that into consideration when designing microtrol. We also don't know how well microtrol is designed against abuse, i.e, whether or not it's susceptible to crushing. Otherwise it administers the same ingredients as are in IR.

Obviously I don't need to say placebo effect again, but I know around 8 or so people currently prescribed to Adderall, and many more who take it anyway. Only one or two of them seem to believe that crushing in fact defeats the controlled release, whereas many more of them have been disappointed that it didn't seem to do so (and irritated, that they couldn't sleep that night). I would expect the experience to be more unanimous if there weren't indeed more to it.