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#1
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Cause of bad reaction?
Yesterday SWIM crushed a 30 mg Adderall XR pill and ingested about 15-20 mg orally around 2 PM. SWIM experienced a nice euphoric feeling that subsides by about 5 PM. After eating and lying down to watch TV, SWIM noticed that he had a very elevated heart rate, and not like during the previous euphoric feeling--it was fast enough to make SWIM very nervous and uncomfortable. SWIM drove around for 2 hours to try to calm himself down, but the uncomfortable heart rate did not go away until several hours later (and heart rate was not completely normal until he woke up the next day).
Is this a common reaction? At such a low dosage, SWIM would not expect this to happen (and SWIM has taken Adderall on a few previous occasions, all at around the same dosage). SWIM tried to think of possible causes--he has taken a generic Claritin pill (Loratadine) the night before, and had drank a cup of coffee at around the time of the Adderall ingestion (admittedly stupid--meant to order decaf). However, the caffeine doesn't seem to explain why the elevated heart rate happened so late in the day. Could the combination with Loratadine have an affect? Any opinions? |
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#2
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Re: Cause of bad reaction?
SWIY experienced what is known as a comedown. The caffeine definitely wouldn't help.
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#4
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Re: Cause of bad reaction?
One should never crush an extended release. They make the comedown less intense and dramatic AND make the expieriance FAR shorter.
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#5
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Re: Cause of bad reaction?
I always thought that a 30mg XR contained (almost) 60mg of amphetamine salt, half of which is instantly released, and the other half to be released about 4 hours after ingestion. If this is the case, SWIY really took 30-40mg of Adderall.
If the food/drink that SWIY talks about before laying down to watch TV was mainly acidic and thus raised the pH of SWIY's stomach, this could be the reason that the extreme effects were delayed a bit. I don't think it could've been the antihistamine from the night before... and of course caffeine probably only made it worse. Last edited by staples; 03-04-2008 at 05:03. Reason: typo |
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#6
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Re: Cause of bad reaction?
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#7
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Re: Cause of bad reaction?
I'm pretty sure it was to prevent confusion between the effectiveness of IR and XR. The fact that the same dosages are available for both forms, as opposed to higher dosages in the XR form, supports this (that is, where doctors would usually prescribe 10mg IR twice a day, they started prescribing 10mg XR), but I would certainly be interested in the specific technical detail if anyone knows it.
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#8
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Re: Cause of bad reaction?
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#9
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Re: Cause of bad reaction?
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#10
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Re: Cause of bad reaction?
You don't like being wrong? Well then look it up yourself. Is this really the place to correct grammar? Funny how you mention grammar when someone answers your question and you don't like the way they did it or the answer they gave you. I mean come on its gotta be the dumbest question I have seen on here in awhile. Does a 30 mg pill contain 60 mg's of Adderall? I even answered you nicely at first, like it's not common knowledge the amount on the bottle/pill is the amount in the pills in the bottle. Hope my grammar is up to a message board standards. Here's a source for you. I hope next time you feel the urge to ask a question you spend 5 minutes doing research. http://www.drugs.com/pro/adderall-xr.html
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#11
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Re: Cause of bad reaction?
I don't mind
Most sources seemed a little ambiguous, the one you just posted is nice though. I did not correct it. Quote:
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Edit: Actually, a question, now, would be: what's the point of crushing up the XR, then, if the ingredients themselves are responsible for the delayed release, instead of a second release of the same dosage? |
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#12
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Re: Cause of bad reaction?
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#14
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Re: Cause of bad reaction?
@OhCasey: I didn't mean to be petty, I wanted to show appreciation for the correction, but not for the apparent tone with which you made the correction. The tone just didn't seem called-for since I didn't even make any absolute assertions... Perhaps a bit passive-aggressive, but (at least to me) there's a certain entertaining incongruity between such a tone and grammar errors that I couldn't resist.
In light of all this, the only things I can think of for the OP, besides possible pH changes (which I can only imagine would be a small factor) is that either crushing XR doesn't really circumvent the time-release , or perhaps can cause the time-release mechanism to also affect what would be IR beads. If the first is true (that crushing doesn't defeat the xr mechanism) then maybe the beads were divided unevenly with a higher concentration of time-released beads. If the second is true, it's essentially the same idea: more amphetamine is released after a delay than expected. Someone who understands the chemistry would have to tell us if this one is possible, though. Is there any food that blocks some part of metabolism to increase bioavailability like how grapefruit juice is supposed to for many benzos? |
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#15
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Re: Cause of bad reaction?
It wasn't a big deal to me. I didnt love the way it was turned away from facts to something personal and about something as trivial as grammar. I'd expect to have my grammar critiqued on a term paper not on a Drug Forum reply explaining the amount actual drug in an amphetamine pill.
That said I do believe that crushing the pills defeats the time release, based on when swim does it and swim insufflates the adderall xr he feels it more then doing it orally and faster. He does only feel a slight increase in effects though so this may in fact not defeat or only partially defeat the time release. It may also be because swim only uses small doses. Now swim knows for sure that when he crushes and insufflates Avinza Capsules (Extended Release Morphine Sulfate) he is getting passed the time release and it is in capsule form with the same size beads as Adderall XR. I think that you are thinking that the Extended release mechanism in Adderall XR is from the fact that levoamphetamine has a fast onset and dextro takes a lil longer to kick in, correct me if im wrong. This cant be Adderall XR's time release system though since regular adderall contains the same amount of Dextro and Levoamphetamine which is roughly 3/4 Dextro mixed salts & 1/4 levo. The name of Shire's time release is actually microtrol though im not sure how it works my guess is just a coating over the balls that slowly dissolves at set times or speeds. I could be wrong about the action of the time release since i cant find any solid info. Just my guess. |
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#16
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Re: Cause of bad reaction?
Thanks for the info, guys.
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#17
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Re: Cause of bad reaction?
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I don't suppose we'll see much more information on it until Shire's patent on Adderall XR expires next year. |
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#19
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Re: Cause of bad reaction?
Youre right its hard to comepare Insufflation and oral use and since im not sticking lil balls up my nose. When swim parachutes 20 mg crushed after 3 days of no adderall usage he notices an increase in affects (compared to no crushing) for about 4 hrs. Swim still doesnt experience a harsh comedown like regular adderall and feels a slight adderall effect for longer this makes swim believe that some of the time release. If you really think that crushhing doesnt defeat the time release then give some reasons or theorys. Swim has encountered more then 6 time releases on various drugs and every capsule and and tablets time release has been defeated by crushing. I do not want to pm you and talk to you about grammar and the intelligence of your posts.
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#20
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Re: Cause of bad reaction?
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Also, doesn't microtrol require a certain stage of metabolism in the gastrointestinal tract which would make them inactive when insufflated? If this is the case, the smooth effects are probably just the shifted metabolization speed of the instant-release d- and l-isomers, and not indicative of the nature of the time-release mechanism. Quote:
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Some medications warn against chewing or crushing because some of the drug may start being absorbed through blood vessels in the gums or cheek, not because it would defeat the time-release. Ambien CR, for example, seems to be this way. Excellent, as these are not things I welcomed you to PM me about. |
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#21
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Re: Cause of bad reaction?
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SWIM isn't into uppers at all, so this is probably a bit sorry? Just a quick 2¢.
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#22
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Re: Cause of bad reaction?
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#23
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Re: Cause of bad reaction?
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I did not have a question. Goodbye! |
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#24
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Re: Cause of bad reaction?
I dunno if its already been answered, but XR's contain the same amount of adderall as IR's. The difference is that XR's are made into tiny beads that are coated with a special ammino acid blend that delays digestion, hence extending release of the adderall. By crushing the beads into powder and re-caping it you can get the same effect as IRs. Parachuting is different than re-capping cuse it allows faster digestion too.
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#25
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Re: Cause of bad reaction?
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This has no logical merit in SWIM's opinion. The difference is dissolution times for rolling paper and capsules is not enough to cause a difference in absorption. Capsules can even dissolve in water in little to no time.... |
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