read someone taking between 25mg and 40mg and that they would not recommend going higher; However, on another forum in another language, members are talking about taking 150mg and 200mg bombs of 4-FMA.
Is it possible to dose this so high? Anyone have any info on what the safest dosages for SWIM to take 4-FMA?
SWIM found this on that same foreign forum regarding dosages:
It is the same dosing at 4-FMA
as in 4-FMP/4-FA i.e.
DOSAGE Low: 50-80 mg
Normal dose is: 100-150 mg
Strong: 150-300 mg
Can anyone confirm this for SWIM?
Another person on some online forum states this...
SWIM feels like 4-FMA has higher potency than 4-FA.
On Swims side, typical dosage for amph is 30 mg, 4-FA 80 mg ,
and for 4-FMA 40 mg is enough
SWIM tried it 2 or three times (not higher than 130mg
and its about the same potency as 4-FA. It felt very good
but SWIM heard people say if you go only a bit higher it gets toxic.
Then SWIM goes on to state that 4-FMA has not been
widely researched. However, the parent compound 4-fluoroamphetamine
has been evaluated and compared to other halo amphetamines. While
the 4-bromo and 4-chloro amphetamines significantly affect serotonin
levels, 4-fluoramphetamine has been found to have minimal effect on
5HT, and contrary to the other halogens, levels are restored within
days of use.
Some concern has been raised regarding potential pulmonary toxicity
of the N-methyl analogue, if this compound is a 5HT2b agonist.
N-methyl-4-fluoroamphetamine may also have a significantly different
neurotoxicity profile than the parent compound (as per methamphetamine
when compared to amphetamine
) and if meth
is anything to go by, will
possibly also have increased actions on the 5HT system.
N-methyl-4-fluoroamphetamine has been noted in Forensic literature.
So, can anyone out there give more info on the safest dosages for SWIM to take 4-FMA at or any valid info regarding dosing 4-FMA period?
chrisjames13 added 1092 Minutes and 20 Seconds later...
There is not much on 4-FMA and the metabolites are unknown so SWIM began looking elsewhere...
Fenfluramine is an amphetamine analog that was once widely prescribed as an appetite suppressant.
Norfenfluramine, the major metabolite of fenfluramine, causes vasoconstriction
dependence on the 5-hydroxytryptamine (5-HI)2A receptor in rat.
4-trifluoromethylamphetamine has certainly been made though
and SWIM doesn't believe there is any evidence that it is
neurotoxic, although SWIM is pretty sure it causes damage to
your heart valves (although not as badly as
3-trifluoromethylamphetamine) -from some forum online.
'Since fenfluramine and its active metabolite norfenfluramine
stimulate serotonin receptors 5-hydroxytryptamine (5-HT) this
may have led to the valvular abnormalities found in patients
using fenfluramine. In particular norfenfluramine is a potent
agonist of 5-HT2B receptors, which are plentiful in human
cardiac valves. The suggested mechanism by which fenfluramine
causes damage is through over or inappropriate stimulation of
these receptors leading to inappropriate valve cell division.
Supporting this idea, is the fact that this valve abnormality
has also occurred in patients using other drugs
that act on
5-HT2B receptors.' -from wikipedia
From a study that SWIM found online....
'The major finding of the present study is that MDMA and
MDA, in a manner identical to drugs demonstrated to induce
VHD and PPH in humans, bind to and activate human re-
combinant 5-HT2B receptors and induce mitogenesis in hu-
man heart valve interstitial cells in vitro. Importantly,
MDMA and MDA activate h5-HT2B receptors within the
same concentration ranges at which they 1) occur in plasma
after a single recreational dose and 2) release biogenic
amines, an activity widely accepted to be a major pharmaco-
logical effect of these agents. We also report that two com-
monly prescribed medications reported to induce VHD in
humans, pergolide and dihydroergotamine (Creutzig, 1992;
Pritchett et al., 2002), also activate h5-HT2B receptors in
Previous studies suggested that VHD-associated drugs
cause heart valve dysfunction via activation of heart valve
interstitial cell 5-HT2B receptors.' -from a 2003 study on mdma
'Our finding that amphetamine derivatives (e.g., fenflura-
mine, MDMA, MDA, and norfenfluramine) also activate h5-
HT2B receptors demonstrates that drugs of other classes also
need to be screened for potential valvulopathogenic actions.'
-from a 2003 study on mdma
'The data presented herein are thus of major
public health importance because they suggest that MDMA
abuse, which is at an all-time high, puts an expanding pop-
ulation at increased risk for developing VHD and primary
.' -from a 2003 study on mdma
After reading all of this...4-FMA doesn't sound much more dangerous than other options out there except 4-FA or methylone
perhaps, which both sound a little on the safer side to SWIM but this is all based on opinion and studies on substances other than 4-FMA of course.
If anyone out there has anything to contribute on the safety or dosages of 4-FMA, please do so for SWIMs sake.