Methylergonovine (Methergine)

[arman]

Althought Methylergonovine is not a research chemical but SWIM can't find any other related thread. Methylergonovine is a tryptamine closely related to ergonovine and LSD, with no information and history of recreational use.

SWIM recently found this chemical in a local pharmacy and got some of them, but he couldn't find enough info about recreational use of Methylergonovine.

According to Wikipedia:

It is a synthetic analogue of ergonovine, a psychedelic alkaloid found in ergot, and many species of morning glory. It is a member of the ergoline family and chemically similar to LSD, ergine, ergonovine, and lysergic acid. Due to its oxytocic properties, it has a medical use in obstetrics. According to Jonathan Ott, methylergonovine has LSD-like actions above 2 milligrams. Clinical dosages are ten times lower.

Alexander Shulgin in TIHKAL:

Ergonovine is a naturally occurring, water-soluble ergot alkaloid, found in both ergot preparations and in many species of morning glory seeds, and there are several reports of LSD-like action at oral levels of between two and ten milligrams. It has an important use in obstetrics, again as an oxytocic, at about a tenth of this dose. This pharmacological potential must be respected in psychopharmacological trials. The one-carbon homologue (the butanolamide rather than the propanolamide) is called methergine or methylergonovine. It is a synthetic ally and is orally effective as an oxytocic at a dosage of 200 micrograms. It also has an LSD-like action at ten times this level.

SWIM first took 4 pills of Methylergonovine, each containing 0.125mg (125 micrograms) of Methylergonovine, just to be sure it is safe. Then after almost 3 days SWIM took 16 of them (16x0.125mg=2mg) but nothing happened, maybe he just feeling a little bit different and some weird feeling in his head but nothing noticable. SWIM suspect he took it too soon and the tolerance from those 4 pills may somehow negatively affected his last experience. Or maybe the recreational dose just starts at 2mg and much more needed for a fully visual experience.

Any ideas? Is SWIM the first one who tries this?

[arman]

SWIM tried it once again, this time 3.75mg (30 pills 0.125mg) Methylergonovine and he seems to just reach its psychoactive dose. SWIM said that it was more like MDMA than LSD, it gives a nice mood-lift but SWIM felt nothing psychedelic. It felt like a medium dose of MDMA.

But the problem was its vasoconstriction effects, which gets strong in this dose. SWIM actually had a some dark chocolate to eat when the vasoconstriction gets too bad. Theobromine is a good vasodilator.

An hour and a half after ingestion on almost empty stomach, SWIM started feeling bad, then nausea, pain in legs (perhaps due to vasoconstriction) and some kind of bad feeling in his head. There was also lots of negative thoughts going in his head. The reason was clear, SWIM never read of any experience report or heard of anyone trying Methylergonovine in such doses.

After about half an hour or 45 minutes SWIM finally threw-up, the stomach was almost empty but he felt better right after vomiting. Then vasoconstriction seems to get very strong quickly, to the point that SWIM couldn't feel his hands.

SWIM was really cold, then he placed part of his chocolate under his tongue to get the fastest possible effect of Theobromine. And after 2-3 minutes the vasoconstriction can't be felt anymore, it was a surprise to SWIM. It was like a 180 degrees turn, suddenly SWIM felt really good and all of the bad feelings gone (except some pain in his legs which was there until the end of trip).

SWIM also somehow felt sedated, but that feeling faded quickly. SWIM experienced a good mood-lift for 6 hours after, but no hallucination, no psychedelic feeling. SWIM couldn't feel any come-down or after effects, nothing noticable. After 6 hours effects started to fade gradually and gently.

SWIM had a positive experience, although it was not what he expects and wants. SWIM guess it might get psychedelic in higher doses but the side-effects of such doses will most likely turn it into a bad experience.