Health - Thoughts? - Dosage discrepency between oral & smoked in Research Chemicals

[trptamene]

So while discussing dosages of 5-meo-mipt in that drug info thread swimmers began to ask the question of why not freebasing these chemicals before vaporization?

In it's salt for these chemicals have a higher point of vaporization and yet must endure more heat to be vaporized than the respective freebase form. This means more of it is likely to degrade before recrystallization in the lungs.

In addition it seems to often be the case that smoked routes require less dosing over its oral counterpart. So there seems to be a problem with the fact that 20mg smoked moxy seems to equal 6-8mg oral moxy. This begs the question, how much of those 20mg is actually making it to the lungs as the active chemical and more worriesomely, what and where is the other 14mg of material?

Even in Shulgin's work he does not seem to make much mention of smoking different tryps/phens in their fb vs salt forms...just simply mentions "smoking"

So...should researchers interested in smoking these compounds make sure to freebase these before use? While this is an issue with dosing, it is more importanly likely an issue with health that I would certainly be interested in hearing peoples opinions on.