Newbie question on Tramadol and euphoria

[trammy]

I get 8 100mg tabs a day...Does nothing..What else can I take with it to increase euphoria

I also have Kolonopins 6mg a day
and 300 mgs of effexer xr
and 40 gms of celexca

I have read about Grapefruit Juice.

anything else????

Thannks for your help in advance

Reputation Comments on this post:

Self-incrimination is not allowed, read the rules. Also, always use drug names instead of brand names, or at least menti...

[samuraigecko]

Do not know if GFJ potentiates Tramadol but ones guess is that since Tramadol is de-methylated by the liver in the same was as codeine that GFJ probably does potentiate Tramadol.

Mixing benzo class drugs (such as klonopin, K-pins, Clonazepam as SWIyou have mentioned or Diazepam, Temazepam, Oxazepam, xanax etc etc) with any "opioid" pain killer is not really recommended though SWIM does do it a lot.

Effexor is an anti-depressant so one would not recommend putting THAT into a mix of something SWIyou want to be euphoric. This is not suggesting that SWIyou discontinue use of the Effexor, SWIM is no doctor (though he does have qualifications applicable to other medical areas) and if SWIyou were prescribed an anti-depressant then chances are it was for a reason and an abrupt discontinuation of this medication could cause a relapse of the symptoms which are related to the reason why SWIyou are on the Effexor.


In short though, Tramadol in SWIMs opinion (his opinion only) is not even really worth it. It is not a true Opiate (in his opinion only) and SWIM and everyone else SWIM knows basically says that Tramadol is crap. This is not to say that others on this forum have not experienced good effects from Tramadol.

A small look around at the threads will show SWIyou that others have had success with achieving euphoria with Tramadol but most others will tell SWIyou that its crap compared to any real opiate.

In SWIMs opinion, a few of those klonopin alone without the Tramadol would be far more successful in getting one to a more "relaxed" state for more information on this SWIyou should search the forum for klonopin or clonazepam to find the relevant recreational dosages and be more informed on the risks etc.

Hope this has been of help.

[OhCasey]

Originally Posted by samuraigecko

Do not know if GFJ potentiates Tramadol but ones guess is that since Tramadol is de-methylated by the liver in the same was as codeine that GFJ probably does potentiate Tramadol.

This has been posted so many times on this board and i know its gone back and forth on why it does and doesnt my guess is it does work with tramadol but im just to lazy to research it.

[samuraigecko]

Yea, SWIM couldn't be bothered researching the GFJ potentiation thing either as he finds both Codeine and Tramadol to be a huge waste of time (his opinion only).

Altho he does wonder how long it will take Apple to release the "i-piate" LOL.

[trammy]

who is swim?

[Fantasian]

try changing to a differant opiate, SWIF always found tramadol had a ceiling at about 300-400mg.

SWIM is someone who isnt me, it stops self incrimination read the rules

[beena]

Originally Posted by Fantasian

try changing to a differant opiate, SWIF always found tramadol had a ceiling at about 300-400mg.

SWIM is someone who isnt me, it stops self incrimination read the rules

Tramadol does indeed have a ceiling effect of 400mg. Taking more is pointless.

[ironmics]

Effexor could block some effects of tramadol, I know other more common SSRI's definitely can, because they inhibit 2D6. I don't know whether or not GFJ would help, since I don't know the complete metabolisms of tramadol. GFJ helps codeine indirectly by block 3A4 and thus making more codeine available to 2D6.

[Paracelsus]

Use the search engine for potentiation of tramadol with grapefruit juice. This has been discussed before (seems to work).

But if there is no euphoria at 800 mg, your friend is not advised to explore further, because he/she might be a non-responder (some people do not experience any opioid-like effects from tramadol because of the lack of a certain enzyme located in liver and gut).

Regarding tramadol not being a "real opiate," of course it isn't, since opiates are natural opium poppy alkaloids (morphine, codeine, etc). Tramadol is an opioid.

[silentghost]

Originally Posted by Paracelsus

Use the search engine for potentiation of tramadol with grapefruit juice. This has been discussed before (seems to work).

But if there is no euphoria at 800 mg, your friend is not advised to explore further, because he/she might be a non-responder (some people do not experience any opioid-like effects from tramadol because of the lack of a certain enzyme located in liver and gut).

Regarding tramadol not being a "real opiate," of course it isn't, since opiates are natural opium poppy alkaloids (morphine, codeine, etc). Tramadol is an opioid.

Sorry if this is a bit off topic, but SWIM believes it is relevant:

As Paracelsus said, it's documented that a certain enzyme in the liver has to metabolize the chemicals to produce the desired narcotic effects. Lack of this enzyme essentially means the drug will pass through SWIY system without any euphoria, and to make it worse, this lack of enzyme is more prevalent in us Caucasians. This is coincidently why SWIM's GP often restricts him to DextroPropoxyphene opiates, because it does not use this enzyme, and thus, more likely to be absorbed. However, it is SWIM's understanding this enzyme (P450-2D6 aka CYP2D6 according to Mr. Whites FAQ) is the also the metabolizer of Dextromethorphan, or the DXM SWIM likes to call it.

Now heres the interesting part- SWIM has a fairly low tolerance to DXM. At 150 pounds, 300mg really fucks him up(swim uses 1-2 times weekly as well. Yet, SWIM has often taken 300mg+ of tramadol with only very very mild euphoria and effects. So if SWIM metabolizes DXM perfectly, why wouldn't tramadol work just as well? And why do some claim tramadol is so intoxicating? Yet 90% of users can't even seem to get a buzz?

[samuraigecko]

One knows this is a little off topic . . but . . One still disagrees with that. Heh, no other evidence will sway him otherwise when there are so many other REAL opiate / opioids out there . . .

Sorry, couldn't resist. . .

[beena]

SWIM remembers reading somewhere that taking Tramadol with other SSRI drugs (such as anti-depressants) is dangerous and can even be fatal.

[yaba]

Originally Posted by beena

SWIM remembers reading somewhere that taking Tramadol with other SSRI drugs (such as anti-depressants) is dangerous and can even be fatal.

My pets doctor has given him venlafaxine and tramadol...

[beena]

Originally Posted by yaba

My pets doctor has given him venlafaxine and tramadol...

Venlafaxine is a SNRI rather than a SSRI anti-depressant so your pet should be ok....

[ironmics]

Originally Posted by beena

SWIM remembers reading somewhere that taking Tramadol with other SSRI drugs (such as anti-depressants) is dangerous and can even be fatal.

I've asked my doc about it, and he's said it was relatively safe, but with 8 100mg per day it could become dangerous.

[yaba]

Thanks swib he will have fun now..

[morph-fiene200]

Effexor is a SNRI (selective serotonin norephinpherine reuptake inhibitor) it can cause serotonin syndrome when mixed with tramadol, which also is a serotonin reuptake inhibitor, Serotonin syndrome is rare but can be fatal. Tramadol is not the most euphoric opioid and it has a thershold, meaning taking more won't increase the euphoria, high doses can cause seizures. Be careful.

[Paracelsus]

The above scenario makes perfect sense, because DXM does not need to be metabolized by CYP2D6 into dextrorphan to become active (both DXM and DXO are active). Although the myth that CYP2D6 poor metabolizers don't get any effects from DXM circulated a lot (as far as I remember it was also included in the DXM FAQ), CYP2D6 poor metabolizers do experience the effects of DXM, and the effects are even much more potent than in extensive metabolizers.
Further reading: this file & the DXM Wiki (in it, use your browser's search function to search for "CYP2D6" - this will get you to the relevant sections).

Where did you get the 90% percentage from? The non-responder rate for tramadol is estimated to 20%.

[silentghost]

Err sorry, 90% was just a guess judging by what SWIM read in the experience reports.

If what you say is true though, SWItrammy could theoretically take, say, 150mg of dextromethorphan, and if he was very very fucked up, it would prove he is a low/poor metabolizer and thus, not suited for this type of opiate. AND it would pretty much prove your theory and why SWItrammy cannot get high off of tramadol. Think SWItrammy would do it?

[ironmics]

Originally Posted by silentghost

Err sorry, 90% was just a guess judging by what SWIM read in the experience reports.

If what you say is true though, SWItrammy could theoretically take, say, 150mg of dextromethorphan, and if he was very very fucked up, it would prove he is a low/poor metabolizer and thus, not suited for this type of opiate. AND it would pretty much prove your theory and why SWItrammy cannot get high off of tramadol. Think SWItrammy would do it?

This is essentially how swim determined he was an extensive metabolizer, 90mg of DXM made him want to curl up and sleep so he could get it out of him. Codeine and tramadol also have enormous effects on him. Right now, he's trying to explore ways to boost hydrocodone to hydromorphone metabolism in his body.

[Orchid_Suspiria]

Effexor is very nasty stuff,swiy should keep that out of the mix if at all possible if swiy wants any euphoria or joy in their life.It doesn't sound like swiy has much of an opiate tolerance so tramadol should still be fun stuff.Once swiy got a good experience with tramadol and it is a really euphoric yet speedy semi opiate.Swim wishes he could still enjoy it.

[ironmics]

Originally Posted by Orchid_Suspiria

Effexor is very nasty stuff,swiy should keep that out of the mix if at all possible if swiy wants any euphoria or joy in their life.It doesn't sound like swiy has much of an opiate tolerance so tramadol should still be fun stuff.Once swiy got a good experience with tramadol and it is a really euphoric yet speedy semi opiate.Swim wishes he could still enjoy it.

I agree completely. Tramadol can be fun at times, but doesn't always rely on opiate receptors to so. For swim, it's usually really speedy and uplifting, I wouldn't say euphoric in the way that other opioids are though. More of a happy loving life excited feeling. Different than other euphorics out there, but interesting and fun none the less.

[Lucid_Dreamer]

SWIM agrees. He says he feels exactly how you described at this exact moment.

SWIM says he ingested 350mg so far and still has 200mg more to go

[trammy]

sorry, i meant tagament

[trammy]

ok SWIM takes 400 mg of Tramadal, tagament, 2 tums and naproxen sodium

and it makes me feel good all day long!