Dihydrocodeine - Coedine

[DeSean]

Can anyone tell me the difference between Dihydrocodeine and Coedine phosphate??

I've only tried the latter, and was considering buying a pack of Paramol.

[Bajeda]

Welcome to the forums. Please review the rules if you have not yet, and avoid self-incrimination in the future (i.e. use swim or other non-first person narrative style).


As for your question....

Dihydrocodeine:

Dihydrocodeine, also called DHC, Drocode, Paracodeine and Parzone and by the brand names of Synalgos DC, Panlor DC, Panlor SS, SS Bron, Drocode, Paracodin, Codidol, Didor Continus, Dicogesic, Codhydrine, Dekacodin, DH-Codeine, Didrate, Dihydrin, Hydrocodin, Nadeine, Novicodin, Rapacodin, Rikodeine,Fortuss, Remedeine, Dico, and DF-118

For use against pain, dihydrocodeine is usually formulated as tablets or capsules containing a quarter grain (15 or 16 mg) or a half grain (30 or 32 mg) with or without other active ingredients such as aspirin, paracetamol, ibuprofen, or others. The usual dose is one tablet taken every 4-6 hours when necessary.

Controlled-release dihydrocodeine is available for both pain and coughing as indicated below as waxy tablets containing 60 to 120 mg of the drug, and some formulations intended for use against coughing and the like have other active ingredients such as antihistamines, decongestants and others. Generally, the starting dose would be 60 mg every 12 hours.

Other oral formulations such as packets of effervescent powder, sublingual drops, elixirs and the like are also available in many places.

Injectable dihydrocodeine is most often given as a deep subcutaneous shot.

The above doses are typical starting doses for "opioid naïve" patients.

There is a poll in this thread, but it isn't very useful as you'll see haha. ----> Codeine vs Dihidrocodeine.


Some info around in this thread too ---> Codeine --> Morphine Conversion: Inducers/Inhibitors


Another useful thread here, bit more info in this one ----> vicodin or lortab in the UK.



Another thread with decent information ------> Dihydrocodeine - Info and CWE


Someone more knowledgeable on this substance should be able to better help.




BajEdit: Some more basic info from the limited research we have in the archive on dihydrocodeine.

Dihydrocodeine differs in its chemical structure from codeine by the saturation of the double bond between C7 and C8 (fig. 1) and possesses, like codeine, antitussive and analgesic properties. However, no dat from opioid receptor binding assays are available for dihydrocodeine. In various tests of nociception, dihydrocodeine was either half as effective, equally effective or twice as effective as codeine (Eddy et al., 1969). The therapeutic doses to produce analgesia are the same for codeine and dihydrocodeine (i.e., 60 mg), but according to early reports, the analgesic effectiveness of dihydrocodeine is higher than that of codeine and nearly equal to that of morphine (10 mg) in postoperative (Gravenstein et al.,1956; Keats et al., 1957) and tumor (Seed et al, 1958) pain when both morphine and dihydrocodeine were administered systematically. These clinical observations are in accord with results obtained when comparing the effects of dihydrocodeine with those of codeine and morphine on nociceptive activity elicited in neurons of the rat thalmus (Jurna and Carlsson, 1989).

And from the same article, here are some more brief excerpts of interest.

However, dihydrocodeine is less potent than morphine. In comparison with codeine, which failed to suppress completely the nociceptive activity evoked in thalamic neurons at doses as high as 3 mg/kg (Jurna et al., 1993) ,dihydrocodeine is more effective and more potent. These results obtained in the animal experiments agree with older clinical observations (for references, see the introduction) when both morphine and dihydrocodeine were injected intravenously. Unfortunately, however, no recent data from controlled studies comparing dihydrocodeine with morphine or codeine in pain patients are available. Furthermore, dihydrocodeine is currently administered orally, and conflicting results were obtained in pharmacokinetic studies. In one study that used a radioimmunoassay, dihydrocodeine administered orally was found to undergo so extensive presystemic elimination that the mean bioavailability was only 21% (Rowell et al., 1983) The levels of acidic metabolites were significantly higher after oral than after intravenous administration.

From the results presented, it is concluded that dihydrocodeine produces analgesia by an action of its own and that this action is due to binding to opioid receptors because it is reversed by naloxone.

Not the most helpful for the purpose of this thread, but some useful bits in the article. May look for some more later to fill in the blanks.

[robshaka]

For Swim DHC gives a much more intense high. When Swim takes codeine he needs to lie down to notice it whereas with DHC the effects are much more pronounced.

[yaba]

Swim done dhc and codeine on several ocations both for his backpain and recreational he found dhc 60mg slow release the best then 30mg dhc instand release and last 30mg codeine with paracetamol (using GWE) He has tryed it in large doses, But doesn't recomend to do the same. A good starting dose would be 30mg dhc and 30-60mg codeine and go on from there.

Hope swiy knows about GWE (cold water extraction) before buying paramol.