Chronic clonazepam administration induces benzodiazepine receptor subsensitivity (Neuropharmacol 1981; 21: 85-9. Crawley JN. Marangos PJ, Stivers J, Goodwin FK.)

[Bajeda]

A new entry has been added to Drugs Archive

Description:
Clonazepam and chlordiazepoxide were administered chronically in increasing doses for three weeks in two different strains of mice. Forebrain [3H]diazepam binding was assayed in groups of mice sacrified at 2, 26, 50 hr and 10 days following the last dose. Scatchard and single point analyses revealed a significant decrease in the number of [3H]diazepam binding sites [Bmax] which persisted for at least two days following chronic clonazepam treatment. The Bmax changes observed following chlordiazepoxide treatment were less pronounced than those elicited by clonazepam. No significant changes in receptor binding affinity (Kd) were detected with either drug. In the clonazepam-treated animals, Bmax values returned to normal by day 10 after drug treatment. Chronic benzodiazepine administration therefore induced a decrease in the apparent number of benzodiazepine binding sites in the mouse forebrain. The magnitude and duration of the observed subsensitivity appears to depend on the potency of the administered benzodiazepine.

To check it out, rate it or add comments, visit Chronic clonazepam administration induces benzodiazepine receptor subsensitivity (Neuropharmacol 1981; 21: 85-9. Crawley JN. Marangos PJ, Stivers J, Goodwin FK.)
The comments you make there will appear in the posts below.

[Laudaphun]

SWIM's marmoset noticed a very similar effect from chlordiazpoxide and now is beginning to wonder if the same is not also true of clonazepam. Temazepam would hit the marmoset quite hard, but a single dose of chlordiazepoxide would make that same temazepam dose completely (or seem so) devoid of any effect for several days. More recently, increased clonazepam consumpiton as was suggested by a health care professional seemed to have a similar effect. The chlordiazepoxide/temazepam experiences were, the marmoset is more confident about since there were not any other substances in the picture at that time. This has puzzled SWIM and her marmoset for quite sometime, but this is the first actual documentation/study indicating as like.