I NEED DRUG INFO

[Hüsker Du]

Alright tomorrow night I'm going to a huge rave / party with my
buddies. I need to know what drugs I can and cannot do while I
am on a MAOI (monoamine oxidase inhibitor). Can anyone
here help me out?
-Hüsker Du

[PYITE]

if you want honesty, you shouldnt be doing ANY drugs while taking a perscription MAOI



for one specific one, taking MDMA while on an MAOI can result in death (serotonin syndrome, google for more info on it)

[Dualpower]

I agree with Pyite



Being on an MAOI will amplify some types of drug you take, possibly to dangerous levels.



What type of MAOI? Maybe you should have stopped taking it for your party...



Safely you can still smoke weed, or drink a little.



In theory you could do some tryptamines in low doses and have quite the
ride. If you haven't experimented though, it might be hard to determine
what kind of dose is for 'fun' and which is an intense personal
experience.



Be very cautious taking anything! You could die! I have no vested interest other than concern. Be Safe!



-Dual

[Blowmonkey]

I bet it's the more regular anti-depressant type of MAOI that targets MAO-B.. The only other anti-depressant MAO-A inhibitor I know of is Aurorex

Anyways, if it's a MAO-B inhibitor, you're going to have trouble finding something that's "safe".. Abstain from using anything actually while on MAO-B inhibitors, sorry.

[Hüsker Du]

I just looked up serotonin syndrome and I smoke alot of weed...


The symptoms of the serotonin syndrome are:

euphoria, drowsiness, sustained rapid eye movement,
overreaction of the reflexes, rapid muscle contraction and
relaxation in the ankle causing abnormal movements of the
foot, clumsiness, restlessness, feeling drunk and dizzy, muscle
contraction and relaxation in the jaw, sweating, intoxication,
muscle twitching, rigidity, high body temperature, mental status
changes were frequent (including confusion and hypomania - a
"happy drunk" state), shivering, diarrhea, loss of consciousness
and death. (The Serotonin Syndrome, AM J PSYCHIATRY,
June 1991)



When I get high off weed this is what happens:


drowsiness, sustained rapid eye movement, overreaction of the
reflexes, rapid muscle contraction and relaxation in the ankle
causing abnormal movements of the foot, clumsiness,
restlessness, feeling drunk and dizzy, muscle contraction and
relaxation in the jaw, sweating, intoxication, muscle twitching,
rigidity,mental status changes were frequent (including
confusion and hypomania - a "happy drunk" state), shivering,
loss of consciousness

[serotonin]

[From Erowid:]
<CENTER>Interactions Between MAOIs, SSRIs, and Recreational Drugs
by Erowid</CENTER>

1. 
   <LI>Avoid mixing MAOIs and SSRIs.
   This can lead to serotonin syndrome and can be dangerous.
   
   
   <LI>Do not mix MAOIs with Stimulants (including MDMA).
   This can lead to hypertensive crisis and can be deadly.
   
   
   <LI>SSRIs in Combination with MDMA
   Generally reduces the effects of the MDMA significantly.
   
   
   <LI>SSRIs in Combination with Psychedelics
   Generally reduce the effects of the psychedelic a bit.
   
   
   <LI>MAOIs in Combination with Psychedelics
   Generally increase the effects of the psychedelic significantly. Be extremely careful.</LI>

SSRIs
Strong SSRIs are significantly more common than MAOIs. Many commonly prescribed pharmaceutical anti-depressants are SSRIs, including Prozac (Fluoxetine), Paxil (Paroxetine), Zoloft (Sertraline), Celexa (Citalopram), and Desyrel (Trazodone).

MAOIs
Strong MAOIs are less common, but include prescription anti-depressants like phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), l-deprenyl (Eldepryl), moclobemide (Aurorex or Manerix), furazolidone, and pargyline. Ayahuasca also contains MAOIs, generally in the form of Banisteriopsis caapi or Syrian rue (harmine and harmaline).


[Original Here]


--------------------------------------------------
<CENTER>Drugs to Avoid with MAOIs </CENTER>
<CENTER></CENTER>
<CENTER>It's not totally understood how various MAOIs interact with the body. Some are more likely to have negative interactions with foods and drugs than others. To be as safe as possible, avoid the following drugs while you are taking an MAOI antidepressant and for two weeks after stopping it. </CENTER>



<UL>
<LI>All SSRIs (prozac, zoloft, and several other anti-depressants)
SSRIs block the reuptake of serotonin in the brain. Because MAOIs inhibit the breakdown of serotonin, the combination of MAOIs and SSRIs can lead to dangerously high levels of serotonin in the brain (serotonin syndrome). Symptoms of serotonin syndrome include nausea, vomiting, blackouts, memory loss, increased blood pressure and increased heart rate.
<LI>Demerol
<LI>Cold preparations (tablets, capsules, or liquids such as Comtrex)
<LI>Cough medications containing decongestants, Dextromethorphan (DXM)<SUP>1</SUP>, or Demerol
<LI>Sinus medications
<LI>Nose drops or nasal sprays
<LI>Nasal decongestants
<LI>Hay fever medications
<LI>Diet pills
<LI>Amphetamines --- speed
<LI>MDMA --- Ecstasy
<LI>MDE, MDA, and other "MD" compounds
<LI>Cocaine --- crack </LI>[/list]


MAOIs can and will dramatically increase the effects of some of these drugs to the point of becoming dangerous. Other plants and chemicals are intentionally combined with some reversible MAOIs (plants such as Syrian Rue or Banisteriopsis Caapi, or their primary active chemicals the harmala alkaloids) to intentionally increase the effects of chemicals such as DMT (as is done in many forms of the ayahuasca brew) or sometimes phenethylamines such as Mescaline or 2-CB. All of these "potentiating" combinations can be dangerous if used improperly.



[Original Here]

[enquirewithin]

Has anyone tried combining pharmaceutical MAOI's with tryptamines--
'pharmahuasca'? I have read that it may not be safe or desirable?