7 amino clonazepam

[JaWill88]

can anyone give swim any informantion on 7 amino clonazepam dose. he has looked into this but couldn't find. he knows it is a metabolite of clonazpam and of course knows doses for clonazepam but not it's metabolite.

[JaWill88]

btw it's really expensive. 1mg is kind of pricey. 10mg reached the hundreds easily. that's why swim really wonders what a dose of this would be. anyone know much about it? a little?

[Zaprenz]

Well it's a metabolite that has shown "slight" anticonvulsant activity (SWIM would read this to mean much less than clonazepam) and it's one more step closer to excretion in the metabolism of clonazepam.

Clonazepam acetylation in fast and slow acetylators.

Six slow acetylators (SAs) and six rapid acetylators (RAs), as determined by sulfamethazine (SMZ) phenotyping, were each given a 2-mg oral dose of clonazepam. Ninety-six-hour urine collections from these subjects were analyzed for clonazepam, 7-amino clonazepam (7-AM, clonazepam nitroreduced metabolite), and 7-acetamido clonazepam (7-ACT, N-acetylated 7-AM). The SA group excreted more 7-AM and less 7-ACT than the RA group; mean (+/- Sd) recovered as 7-AM was 22.7 +/- 5.0% for the SA group and 13.6 +/- 4.1% for the RA group and mean (+/- SD) recovered as 7-ACT was 1.5 +/- 0.4% for the SA group and 3.9 +/- 1.8% for the RA group. Both differences were substantial (p less than 0.02 by unpaired t test) and indicate that the rate of acetylation of 7-AM to 7-ACT in the biotransformation of clonazepam is determined by the acetylator phenotype.
PMID: 7273597

^suggests rapid acetylators will get rid of it quickly. Also what effects will the 7-Amino- group have? possibly reduce entry in to the brain - [?Not sure] - likely to have considerably less potency than clonazepam.

Most places selling it will likely be selling it for use in analytical techniques. If SWIY is suggesting some other use of 1mg (!) for super high prices - sounds a bit of a no-brainer to SWIM.