Pharmacokinetics Mescaline?

[Smee]

Hey, swim's first post here.
Swim is working on a project about mescaline, and also has to find information about the pharmacokinetics. Does anyone know something? Swim has been looking all over internet but couldn't find the stuff swim needs.

Any help appreciated

[Shampoo]

Originally Posted by Smee

Hey, swim's first post here.
Swim is working on a project about mescaline, and also has to find information about the pharmacokinetics. Does anyone know something? Swim has been looking all over internet but couldn't find the stuff swim needs.

Any help appreciated

More specifications as to what you are seeking may elicit more results.

That being said,
Heres some basic Pharmacokinetics of C11H17NO3 (mescaline) and their sources for further investigation.

-Completely digested by gastrointestinal tract.
-Active hallucinogenic dose (mescaline sulfate) ~250-600mg
-above 15 times a normal hallucinogenic dose is the LD50 (150mg/kg or more)
-More than 40% leaves body undigested
-Maximum concentration in brain (3.5-4 hours)
-Marked increase in striatolimbic system activity(this is why it was originally classified as a psychotomimetic for schizophrenia)
-Physiologically active at 5mg/kg
-Basic implicated neurotransmitters 5-HT2a; 5-HT2(6), Alpha &Beta Norepinephrine, Dopamine, Glutamate

*United States Department of Justice: U.S. Drug Enforcement
Administration Peyote & Mescaline.
*Oepen, G.; Fuenfgeld, M.; Harrington, A.; Hermle, L. (1989) Right
hemisphere involvement in mescaline-induced psychosis. PsychiatryResearch Vol. 29 (3) Sep. 1989, 335-336.
*Aghajanian, G. K.; (1980)Mescaline and LSD facilitate the activation
of locus coeruleusneurons by peripheral stimuli. Brain Research Vol
186(2), Mar. 1980, 492-498.
*AghajanianG and MarekG. Serotonin and hallucinogens.
Neuropsychopharmacology: Official Publication of the
American College of Psychopharmacology, 1999; 21 (2):
16S-23S

Reputation Comments on this post:

Useful Info

[Smee]

Thanks a lot
I guess I can find more using all this

[Zaprenz]

SWIM would speculate it may be quite hard to find a lot of information compared to what is possible with many modern drugs (specifically licensed drugs).

Pharmacokinetics is essentially what the body does to the drug(absorption, metabolism, excretion etc)

Pharmacodynamics is essentially what the drug does to the body (receptors it targets, enzymes it inhibits etc etc)

Since it was first discovered and even since Shulgin's research, MANY new analytical technologies would in theory allow for much greater understanding of the metabolism of mescaline. No one will be funding them (I.e big pharma companies) and the few that are funded will have to go through all legal problems of research with it [more importantly they may need a scientific reason]

The other problem is as mescaline was discovered such a long time ago many of the original papers might not be available in electronic format. [So they might be there but harder to get hold of]

As Shampoo has detailed though - there are useful basic pharmacokinetics (t1/2, basic bioavailability, %excreted unchanged etc). Further information may also be possible via prediction & comparison to other compounds or endogenous transmitters as it's a fairly basic PEA structure.