NO effect from morphine - ... help?

[mikebobjohn]

I come to you all completely bewildered. I've read that Morphine yields the same effects of heroin when both are used orally, and that morphine yields both very good pain control, as well as a significant euphoria.

I have next to no opiate tolerance, and I took a 15mg ms contin pill that my doctor perscribed, and I felt absoluetly nothing. I kept waiting and waiting because the doctor said it could take awhile (because the pill is time released), but eight hours later I still felt as if I hadn't taken anything.

I have also tried Oxycodone, the immediate released form pill, at both 10mg at once and 15mg at once, and both dosages have failed to produce really any kind of a euphoria, and the pain relief is minimal.

I tried subutex (buphrenorphine) before I tried any of these others, and I found that it helped the most with the pain and gave me more of a euphoria than ms contin or oxycodone, but also gave me urinary retention.

I took 100mg 4 times a day of tramadol over the last few days, and today was my first day back on oxycodone (after only a week of taking it at mostly just 10mg at once), so today I took 15mg of it and in comparison to the tramadol, which effects were very mild, the tramadol gave me more pain relief AND more euphoria (even though there almost isn't any euphoria with tramadol).

SO - the theme seems to be that I'm responding better to these synthetic opoid drugs (such as tramadol and... is buphrenorphine synthetic too?0 than I am to the oxy, morphine, vicodin (one pill of vicodin didnt do anything either). I also used one 12.5mcg duragesic fentanyl patch and I noticed more of a pain relieving effect than anything else I'd tried. It kind of numbed me out, but there was still no euphoria and I actually felt a little worried. I didnt like it so i took it off after about 16 hours (it didnt start working for about 14).

Anyway, I'm wondering if maybe the trend of opiate drugs not working with me can be described and then remedied by something. Could I not have the proper enzymes in my body to make use of these medicines? Could my PH not be right? Could my genetic sensity to drugs (that the docs found on a genetics test they did) be affecting it?

And how do I remedy this?

And, given that buphrenorphine probably worked the best for me (aside from the urinary retention), is there anything like buphrenorphine, but stronger, that I could try that might not give me urinary retention?

Help much appreciated. I really need pain and mood management drugs (as my symptoms are possibly caused solely by stress), and I don't know what else to ask my doctor for. I also tried 20mg of ketamine orally and that didn't do anything.

Can someone explain this phenomenon? There has to be an explanation and a solution as to why I feel nothing or next to nothing when I take drugs that are very similar to the most well liked and addictive drug in the world (heroin).