Originally Posted by dude
So I don't need to give up on Subs forever then? So if I do decide to quit Oxy's at this level, a doctor can help me with Subs? Even though as you say "Suboxone
doesn't bind to the mu receptor" I still will feel "normal" on the proper dose of Suboxone? Or will I have to suffer some and adapt? Thanks
does bind to the mu receptor, it just doesn't activate it as much as oxycodone
does. Oxycodone is a full agonist at the mu receptor while buprenorphine is a partial agonist. This just means that while the binding affinity (it's attraction) for the mu receptor is much stronger, it only partially activates or stimulates the receptor.
I do think a doctor could likely work with you and find a dose that would keep you comfortable. Typically, at first they do what is called an induction where they administer suboxone to you while you are in the doctor's office. They will wait a little bit and see how you feel, and give you more until you feel comfortable. This might take up to 2 hours or so, but it is probably the best way to find a workable dose. 360mg/day is a pretty heavy dose.
On the other hand, suboxone does not work for everyone. Some people need methadone
which can be a real pain in butt to get everyday if have to get it from a clinic. On the otherhand, if you are prescribed x12 30mg oxycodone pills each day, then you must have an issue with pain which makes acquiring methadone much easier. Some doctors will prescribe methadone and then additional oxycodone to take for breakthrough pain. I've read many accounts of chronic pain patients that go from high doses of oxycodone each day to methadone and oxycodone. But once a portion of the oxycodone is replaced by methadone most of the patients will say that the oxycodone loses most of it's euphoria
With suboxone, it is harder to switch from a full agonist such as oxycodone to suboxone(buprenorphine) than it is to switch from suboxone back to oxycodone. Some people report that buprenorphine helps with pain, and others say that it does not... so that might be an issue.
Most of the time, the naloxone that is in suboxone has no effect on people, but if you go to a doctor, I would request that they do your first week or so with subutex
(buprenorphine without the naloxone) just in case you are hypersensitive to it as it can absorb into the GI tract to an extent.