Drug info - Tma

[Euphoric]

From wiki, http://en.wikipedia.org/wiki/Trimethoxyamphetamine

TMAs, also known as trimethoxyamphetamines, are a family of isomeric psychedelic hallucinogenic drugs. There exist six different TMAs that differ only in the position of the three methoxy groups: TMA, TMA-2, TMA-3, TMA-4, TMA-5, and TMA-6. The TMAs are analogs of the phenethylamine cactus alkaloid mescaline. The TMAs are substituted amphetamines, however, their action does not resemble that of the unsubstituted compound amphetamine, which is a stimulant and not a psychedelic. It is reported that some TMA's exhibit a range of emotions ranging from sadness to empathy and euphoria. Several TMAs were first synthesized by the chemist Alexander Shulgin. Synthesis data as well as human activity data has been published in the book PIHKAL.

The most important TMA compound from a pharmacological standpoint is TMA-2, as this isomer has been much more widely used as a recreational drug and sold on the black market and as a "research chemical"; TMA (sometimes referred to as "mescalamphetamine") and TMA-6 have also been used in this way to a lesser extent. These three isomers are significantly more active as hallucinogenic drugs, and have consequently been placed onto the illegal drug schedules in some countries such as Japan. The other three isomers TMA-3, TMA-4 and TMA-5 are not known to have been used as recreational drugs to any great extent, and remain obscure scientific curiosities.

From erowid:

TMA-2, or 2,4,5-TrimethoxyAmphetamine, is a synthetic chemical that is related to, but more potent than mescaline. It has both stimulant and psychedelic effects. It's qualitative effects on mood alteration and sensory enhancement are similar to mescaline.

Dose
10-50 mg. A. Shulgin suggests that there is only a small margin between the dose needed to produce psychoactive effects and a toxic dose (Shulgin, 1976). Toxic dose in humans is not known.

Law
TMA is a schedule I substance in the United States, making it illegal to buy, sell, or possess. TMA-2 - TMA-6 are all positional isomers of TMA, making them schedule I substances as well. TMA-2 has been placed in Schedule I by the U.N. Narcotics Commission.

Chemistry
2,4,5-trimethoxyamphetamine (TMA-2) is a synthetic chemical which can be derived from the Calamus root's active ingredient Asarone.

Psychopharmacaology
TMA-2 is known to be a 5-HT2 agonist.

History
TMA-2 was first synthesized in 1933 and it's psychoactive properties were recognized by A. Shulgin in 1962.

For PIHKAL entries: TMA Entry from PiHKAL
TMA-2 Entry from PiHKAL
TMA-3 Entry from PiHKAL
TMA-4 Entry from PiHKAL
TMA-5 Entry from PiHKAL
TMA-6 Entry from PiHKAL

According to http://www2.parl.gc.ca/HousePublicat...de=1&File=27#1
2,4,5–trimethoxy–a–methylbenzene- ethanamine is a schedule I substance in Canada.