meth/amp from acacia berlandieri/rigidula?

[allyourbase]

I am myself a denizen of west texas, and I thought Id just share a bit of info. the acacia trees heremake their own amphetamines. NO JOKE. not only do they contain DMT (a favorite tryptamine of mine), but they also contain 4methoxyamphetamine,4hydroxyamphetamine, methamphetamine, amphetamine, methoxyamphetamine, and Ive heard they contain PMA but Im skeptical on the latter. this is something you australians might consider, seeing as youve no longer easy access to Pfed. with the right biological material, and proper fractioning, you could easily EXTRACT your meth, PREMADE!!!! Edited by: allyourbase

[Alfa]

I found this posted on the Hive years ago. Did anything come from this info? Bioessays, extractions, etc.? Does anybody know if these are trace amounts or substantial amounts.

[allyourbase]

Possible resources:


Camp, B. J.; Lyman, C. M. (1956) The isolation of N-methyl beta-phenylethylamine from Acacia berlandieri. J Am Pharmaceut Assoc Sci Ed 45(11):719-721


Camp, B. J.; Lyman, C. M. (1957) The toxic agent isolated from Acacia berlandieri, N-methyl beta-phenylethylamine. Southwestern Vet 10:133-134


Camp, B. J.; Adams, R.; Dollahite, J. W. (1963) The chemistry of the toxic constituents of Acacia berlandieri. Annals New York Acad Sci 111(2):744-750


alkaloidal study of Acacia Rigidula:


"Soxhlet exraction procedure Still frozen A. rigidula was packed into Whatman single thickness cellulose extraction thimbles (ca 50g/thimble, 200 g total) and extracted continuously for 24 h with MeOH. The MeOH was removed and replaced with CHCl3 and the extraction continued for an additional 24 h. A pilot study established that the extracts could be safely concentrated by rotary evaporation (water aspirator). The MeOH extract was concentrated and the residue dissolved in 100 ml of CHCl3. This solution was extracted X 3 with 50 ml portions of 10% aq. HCl . The acid fractions were combined, the pH adjusted to ca 10.3 by addition of aq. NaOH, and the resulting solution was first extracted X 3 with 50 ml portions of CHCl3, followed by extraction X 3 with 50 ml portions of EtOAc. These organic extracts were combined, dried with MgSO4, filtered, concentrated under vacuum, and stored under argon prior to analysis by GC-MS. The CHCl3 fraction from the Soxhlet extraction was handled in an identical fashion to the MeOH extract with the exception that it was not first concentrated prior to aq. acid extraction. The MeOH and CHCl3 extracts from the Soxhlet extraction were not combined. Acid extraction of plant material Acacia rigidula, 100 g, was placed into a 1 l Erlenmeyer flask and mixed with 500 ml of 10% aq. acid (HCl and HOAc were both used). The suspension was stirred under argon at 60° overnight. The darkened suspension was filtered through glass wool covered with a 2 cm bed of sand. The filtrate was extracted X 2 with 100 mL portions of EtOAc followed by X 3 extraction with 100 ml portions of CHCl3. The pH of the filtrate was adjusted to ca 10 by addition of NaOH pellets. This solution was extracted X 3 with 150 ml portions of CHCl3, followed by extraction X 3 with 150 ml portions of EtOAc. The organic extracts were combined, dried over MgSO4, filtered, concentrated under vacuum and stored under argon prior to analysis by GC-MS." [The authors analysis by GC-MS revealed the following alkaloids in Acacia rigidula: 2-Cyclohexylethylamine; N-2-Cyclohexylethyl-N-methylamine; Phenethylamine; N-Methylphenethylamine; N,N-Dimethylphenethylamine; Amphetamine; Methamphetamine; N,N-Dimethyl-a -methylphenethylamine; p-Hydroxyamphetamine; p-Methoxyamphetamine; Tyramine; N-Methyltyramine; Hordenine (anhaline); Dopamine; N-Methyldopamine; N,N-Dimethyldopamine; 3-Methoxytyramine; N-Methyl-3-methoxytyramine; 3-Hydroxy-4-methoxyphenethylamine; N-Methyl-3-hydroxy-4-methoxyphenethylamine; 3,4-Dimethoxyphenethylamine, N-Methyl-3,4-dimethoxyphenethylamine; 3,4,5-Trihydroxyphenethylamine; N-Methyl-3,4,5-Trihydroxyphenethylamine; Mescaline; N-Methylmescaline; Trichocereine; 3,5-Dimethoxytyramine; 3,4-Dimethoxy-5-hydroxy-b -phenethylamine; b -Methoxy-3,4-dihydroxy-5-methoxy-b -phenethylamine; 3,4-Dimethoxy-a -methyl-5-hydroxy-b -phenethylamine; Tryptamine; N-Methyltryptamine; N,N-Dimethyltryptamine; Nicotine; Nornicotine; Anhalamine; Anhaladine (N-methylanhalamine); Anhalonidine; Peyophorine; Pipecolamide; p-Hydroxypipecolamide; 1,4-Benzezediamine and 4-Methyl-2-pyridinamine. Edited by: allyourbase

[allyourbase]

these plants grow everywhere, I may have a friend do an extraction, I doubt wed be able to go through with any sort of actual chromatogrophy, but I may be able to give you a basic ratio of alkaloid/dry plant weight fairly soon. =)

[JewishNazi]

surely most of those would only be in trace amounts. Cant wait to hear how your friends extraction goes

[Alfa]

Let us know. Most interesting.

[600538411]

A plant that produces it's own meth, too funny... I bet there are some fiends out there thinking they wish their body had evolved with this adaptation


Sounds interesting enough but I couldn't imagine these alkaloids being available in more than trace elements as has been said before. Good luck anyway!

[Nahbus]

Must suck to be a tree when you're on meth.

"mutha fuckin roots, I just gotta moooove"



...

*cricket*

...

*cricket*

[allyourbase]

rigidula is supposed to have around the same DMT content as maidenii. as for the amphetamine contents, these studies were performed because cattle would eat the foliage of the plants not protected by their spines, and either get sick, or go on hypertensive rampages. so they may not be so trace. I will keep everyone informed.

[JewishNazi]

After reading that, it makes the nearby park much more interesting

[raven3davis]

This is all I have heard of the meth tree


http://www.cognitiveliberty.org/shul...hive/acacia.ht m


Where did you find information on this. Has it been proven? More info would be nice but I cant find any.

[kingdxm]

Apparently meth and several other so-called synthetic amphetamines have been found in 2 Texas plants. I am not going to go into details UTSE. But what is next natural MDA or 2-CB? Has anybody ever wondered why there are so many natural precursor chemicals(such as safrole, piperonal, asarone, apiole, anethole, croweacin, etc..etc...etc) but no drugs in these plants. Why is it this Texas plant can do it(how would be nice)but no other plant?

Shulgin has called these plant oils "essential amphetamines ", probably combining the words essential oil and of course amphetamines. He attempted to challenge the "oil to amphetamine" concept by making a mixture of 1 part MDA, 2 parts TMA and 5 parts MMDA. A total of 100mg of this combination( which he had named the "pseudonut cocktail" for pseudo-nutmeg ) should be equivelent to the safrole, elemicin, and myristicin that would be in 5 grams of nutmeg. And 100mg indeed produced quite a sparkle and considerable eye dialation.

So did plants use to make these wonderful chemicals? I think they did, but what happened? Perhaps it was the industrial age and the toxins we spew into the air and the ground and it changed the chemistry of these plants. Perhap something else. Unfotunatly we will probably never know since we do not have any living plants that are several hundred years old to analize. And have you noticed that the psychoactive plants we have now are getting weaker and their psychoactive chemical contents are less and less. Hell why do you think we are cloning pot and tomatoes. Because the ones that grow naturally are sickly need lots of fertilizer to grow and basically are dying off. I an not going to get into into a religious discussion, I just have to say this: I don't think a Divine Creator made it so we have to eat grams and grams of bile tasting herbs just to have an effect.

I recently had a post that disappeared(perhaps aliens?) about a new way to make MDMA. I have posted this on several other sites for a couple of years now and I always get the same response...NOBODY even makes a comment. Not even a FUCK YOU, that will never work....nothing. Even on this site, NOBODY has made ANY comment on it, Why???

O.K. enough ranting here is my general idea for what I feel is sort of a "natural" way to make MDMA. the 2 main ingredients are safrole and glycine.
Laugh if you want. Glycine when heated converts into methylamine. I have heard many people say if only there was a one-shot method to just add ammonia to safrole that would be great. But even if you make the methylamine in a mix of safrole, you just get safrole and methylamine. If I were a plant this would be my way of turning those essential oils into active alkaloids, but I am not. A catalyst is need to break that double bond(safrole) to add this glycine(methylamine) .Several research scientists have found a way to make phenethylamines by heating amines and styrenes together in a microwave. They produced N-phenylamphetamine from aniline and propenylbenzene in 10 minutes and got a 42% yield, that pretty cool. Maybe this could work here, maybe not. There has got to be a catalyst out there that can achieve this, because it seems to me to be an aweful waste of a plants time just to produce some oil that has no use for the plant and just smells pretty.

Remember this, every recipe we have now is posioning our enviorment(hell look at meth labs!!) and ourselves. And every recipe for every drug someone had to think it up first. Chemistry is a pretty new science, and new way of doing things are being thought up all the time. It derived from alchemy, and they thought that they could turn lead into gold, now we can(unfortunatly it's radioactive, but it's gold alright).

I hope somebody will respond to this site, preferrably with good comments and maybe some ideas. Isn't that why we are here, to learn from each other the art and science of organic chemistry?

[Nagognog2]

Nobody is going to comment on such an obtuse post. What plants? What chemicals? What synthesis? Explain where you are going with this clearly and concisely. This is a forum for chemical knowledge. Not a guessing-game to sort out the illuminati from the lesser bi-pedal animals roaming your range. Clarify. Or closed.

[firewall]

Originally Posted by kingdxm

it seems to me to be an aweful waste of a plants time just to produce some oil that has no use for the plant and just smells pretty.

That isn't how nature works. Plants produce oils like safrole because they ward off insects. If those oils work well for them, then there is no reason for them to convert the oils into alkaloids. But, yes, this thread should probably be moved or closed.

[kingdxm]

I was simply trying to find a way to make MDMA using methylamine(from glycine) and safrole.

Acacia rigidula has beem found to contain amphetamine, methamphetamine, dimethylamphetamine, 4-methoxyamphetamine and 4-hydroxyamphetamine.

Does anybody out there care about finding a new way to make psychedelic amphetamines from plant oils or am I the only one.

BTW plant produce alkaloids to ward off animals as well.

and I did mention a synthesis about amines and styrenes reacting to make phenylethylamines, that is an actual synthesis. If I could post the ref. I could show you, but I got in trouble the last time I did that.

[stoneinfocus]

hose Texas plants are maybe more bad-ass then all the innocent other plants in the world, so there´s the tempting of satan ( ) )to resist these evil substances.

remeber all thes echems happen to work by co-incidence and are just a symbiosis product that happened to work in the enviroment and the plant.

The chemical way would be a wacker to transform the safrol to MDP2P and then maybe the methylamine would add through some fance enzyme or even some electromagnetic range of waves that´s absorbed fro the sun, by th eplant.

Wouldn´t this mean, according american law, that, it it´s naturla occuring, it should be legal to buy? -just kiddin o course it´s stil lcontrolled.

ten again, how easy should it get, in oragnic chemistry it´s hardly this easy to get to a wanted substance, even methylamine from C2HO is harder to do.

[kingdxm]

The amphetamines in these plants are very minimal, so I doubt a bunch of methheads are going to go to Texas and get high . BTW these plants is legal, swim knows where to buy them.

Could safrole be made into MDMA using a PTC, methylamine and a catalyst, maybe a compound with a SO3+ such as methyltolusufonic acid. in breaking double bonds using acids there are these:
HCl
HBr
HI
hypochlorite
sulfuric acid

HCL takes too long to react and even after a week you may get a 10% yield. HI works but when you add the methylamine the iodosarole converts back to HI and safrole. hypochlorite wont work either, since it would put the chlorine atom in the 3-position on the side chain. sulfuric acid although it works, sulfuric acid is so reactive that it destroys the methylene bridge. but a sulfonic compound which is reactive but not quite as strong, could join to the
double bond. then methylamine would replace the sulfonate and make MDMA, the sufonic acid would simply act as a catalyst.

[Jatelka]

A new entry has been added to Drugs Archive

Description: Originally published in Phytochemistry

To check it out, rate it or add comments, visit Toxic Amines and Alkaloids from Acacia Berlandieri (Clement, et al, 1997)
The comments you make there will appear in the posts below.

[Jatelka]

A new entry has been added to Drugs Archive

Description: Originally published in Phytochemistry

To check it out, rate it or add comments, visit Toxic Amines and Alkaloids from from Acacia Rigidula (Clement et al, 1998)
The comments you make there will appear in the posts below.

[fnord]

anyone know about extracts and if they are psychoactive?



wikipedia:


In 1997[3] and 1998,[4] researchers at Texas A&M University reported finding amphetamine and methamphetamine in the foliage of two Acacia species native to Texas, A. berlandieri and A. rigidula. Previously, both of these compounds had been thought to be human inventions.

A. berlandieri contains a number of diverse alkaloids, the most plentiful of which are N-methylphenethylamine, tyramine, and phenethylamine. In a recent study, researchers identified thirty-one alkaloids in samples of plant foliage, including trace amounts of five amphetamines previously believed to be human inventions:[5] amphetamine, methamphetamine, N,N-dimethylamphetamine, p-hydroxyamphetamine and p-methoxyamphetamine. Other trace alkaloids include DMT (found in many related species), nicotine, and mescaline (found in many cacti but infrequently in other plants). The same group of researchers later reported finding most of the same alkaloids in A. rigidula, a related species also native to the Southwestern U.S.

[old hippie 56]

Quite interesting to say the least. Must tell swim to be on the lookout for these two plants in his wanderings.

[rxbandit]

Some more information on the alkaloid content as well as incriminating evidence regarding the illicit use of methamphetamine among livestock and sheep...

Abstract:
Consumption of Acacia berlandieri Benth. by domestic livestock during periods of drought may result in a locomotor ataxia, as well as having negative effects on intake and male fertility. Four phenolic amines (N-methyl--phenethylamine, tyramine, N-methyltyramine, and hordenine), had previously been extracted from the plant, and N-methyl--phenethylamine has been shown to negatively impact fertility in female Angora goats. In order to clarify the possible role of other secondary compounds from Acacia berlandieri on non-lethal toxicities in domestic livestock, leaf samples collected in the spring and autumn were subjected to rigorous chemical analysis. In addition to the four previously detected amines, 29 other alkaloids and amines were isolated and identified by GC-MS, these including nicotine, nornicotine, mescaline, mimosine, and four amphetamines. A significant increase in the number and relative quantities of these compounds was observed in late season foliage.


http://www.ingentaconnect.com/conten...00002/art00240


And some information on possible extraction technique

[top]JOURNAL ARTICLE

[top]Technical note: an improved method for extraction and quantification of toxic phenethylamines from Acacia berlandieri

I. J. Pemberton, G. R. Smith, T. D. Forbes and C. M. Hensarling
Texas A&M University Agricultural Research and Extension Center, Overton 75684.
N-methyl-beta-phenethylamine (NMPEA) has been previously identified as the toxin causing locomotor ataxia in sheep and goats grazing the browse plant, Acacia berlandieri. We describe a simplified procedure for extraction and quantification of naturally occurring beta-phenethylamines from this Acacia species. Dried, ground plant tissue was extracted (1:20 wt/vol) with 1% glacial acetic acid and filtered. The filtrate was passed through a high-sulfonated polymeric solid-phase extraction (SPE) tube, which retained the compounds of interest (tyramine, hordenine, NMPEA) but allowed many impurities co-extracted from the plant tissue to be washed through. Amines were eluted from the tube, then separated and detected by reversed-phase HPLC. Extracted amines were resolved by HPLC in < 15 min, and UV-absorbance spectra matched those of authentic standards. Recovery efficiency of amine standards (125 micrograms/mL) from SPE tubes averaged 97, 101, and 98% for tyramine, hordenine, and NMPEA, respectively. Excess sample loss was prevented and the large volumes of solvents required for liquid-liquid extraction eliminated by use of solid-phase extraction techniques.

http://jas.fass.org/cgi/content/abstract/71/2/467

[Alfa]

fnord & rxbandit: please make sure you do not post formatting of the original page when you copy-paste an article. Simply dropping your text in notepad and then copying that, will get rid of anything you don't want in there.

Anyway: 5 threads merged.

[headstrong]

• Hi all! SWIM is a newbie here,in chemistry,and bad grammer,sorry if he will make mistake. He has 1,85 kg/1.850 grams of Accacia Berlandieri foliages. Need some advice-for info purpose only. [IMG]file:///F:/picture/1.jpg[/IMG]

Here the extraction process that SWIM has done and plan to do:
1.Freeze 24 hours
2.Dried in oven below 80c(become 400 g dried foliages)
3.powder and soak in denature alcohol for 2 x 24 hours,will do it twice-has been 3 hours for now.
4.Filter and evaporate-resin
SWIM do point number 1-4 just to compress the volume and plan to do A/B reaction to the resin:
1.Add Zippo lighter fluid,distilled water. Collect the water. Defatting?
2.Basify:add lye-collect the oil
3.Add hcl,Zippo lighter fluid-filter and evaporate. Crystal?
SWIM can only plan simple reaction above but don't know it will work or not,hope some advice about it.

[headstrong]

Swim has done twice accacia berlandieri extraction, 1850g and 2800g. Poor yield for both of these, 10 mg crystal for the last 2800g wet foliages. As like Kingdxm said,the alkaloids in this plan is very minimal.

Reputation Comments on this post:

thanjks for teh update.