Drug info - 4-Methylmethcathinone (2-Methylamino-1-p-tolylpropan-1-one) mephedrone

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Please post info about Mephedrone here.

Please use this thread to add information about:

 

• 1Mephedrone molecule & names
• 2Mephedrone Experiences
• 3Mephedrone dangers & health concerns
  • 3.1Incidents with mephedrone
  • 3.2Mephedrone addiction warning
  • 3.3Mephedrone side effects
• 4Mephedrone pharmacology
• 5Mephedrone dose
• 6Mephedrone Appearance
• 7Mephedrone legality
• 8Mephedrone history and prevalence
• 9Mephedrone degradation
• 10Mephedrone files
• 11Mephedrone images

[top]Mephedrone molecule & names

Names: Mephedrone, p-methylmethcathinone, bk-p-methyl-methamphetamine, 4-MMCIUPAC: 2-Methylamino-1-p-tolylpropan-1-one
Mephedrone should not be confused with Meph (Methyl-Ephedrine)

Mephedrone has been around for a short time and hospitalisations and serious side effects are frequent.

[top]Mephedrone Experiences

Experiences with Mephedrone should be posted here: Mephedrone experiences

[top]Mephedrone dangers & health concerns

Unlike most other research chemicals there are no studies on mephedrone health risks at all. The only data available is empiric (experience reports) and comparing mephedrone to its amphetamine analogue p-MethylMethAmphetamine. Mephedrone has caused deaths.

[top]Incidents with mephedrone

There are several threads that together expose that there is a real danger with mephedrone. An overview be found here:
Mephedrone Experiences & Side-Effects Database

Here are some highlights:

1. Mephedrone: body turned blue with red and purple, limbs numb. URGENT RESPONSE NEEDED!
2. Mephedrone (2-Methylamino-1-p-tolylpropan-1-one) experiences
3. Should swim be worried about extreme cold/freezing on mephedrone?
4. mephedrone is not a toy: Heart problems
5. Mephedrone hospitalization: Purple knees, extremities
6. Mephedrone: Potential Neuropathy - Extreme side effects. PLEASE READ
7. 4-Methylmethcathinone (2-Methylamino-1-p-tolylpropan-1-one) "mephedrone"
8. Mephedrone violent convulsions: hospitalisation
9. mephedrone: felt like his heart was going smash through his rib cage
10. Mephedrone fatigue: heart & breathing problems
11. Help Feeling Mephedrone effects 48+hrs after last dose
12. Teenager dies of mephedrone overdose
13. Possible mephedrone death
14. Mephedrone and amnesia

This drug has caused deaths.

[top]Mephedrone addiction warning

Mephedrone is a very addictive substance. A very high % of users report, that they will not stop before all mephedrone is gone.

[top]Mephedrone side effects

Many users report blueing of the knees & limbs, vasoconstriction, heart problems, breathing problems, convulsions, fatigue, mouth sores. Side effects occur at relatively low doses. Mephedrone has caused deaths.

[top]Mephedrone pharmacology

Not much is known about this widely used drug yet. It has no direct analogs with more information.

Random pharmacological bits and pieces swim came across on the internet: (The second one is about methcathinone but perhaps is relevant)

Pharmacological: 4-Methylmethcathinone is sympathomimetic stimulant. From proposed SAR modelling, 4-methylmethcathinone is expected to have similar pharmacological properties to methcathinone, but with increased activity on the serotonin neurotransmitter systems. Methcathinone is suggested as being more potent than its parent cathinone, and methamphetamine (1) - - - (1) Martin D Schechter; Drug-Drug Discrimination: Stimulus Properties of Drugs of Abuse Upon a Serotonergic-Dopaminergic Continuum; Pharmacology Biochemistry and Behavior Volume 56, Issue 1, January 1997, Pages 89-96

Methcathinone is a drug with a high abuse potential, with prolonged, high dosages known to cause psychosis and withdrawal tremors. Methcathinone is regarded as being similar in profile to methamphetamine in relation to neurotoxicity, with marked decreases in DA levels noted among abstinent users. While generally below levels associated with Parkinsons Disease, this is considered to be demonstrative of permanent, or semi permanent neurological damage (2) - - - (2) Una D. McCann, Dean F. Wong, Fuji Yokoi, Victor Villemagne, Robert F. Dannals, and George A. Ricaurte; Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428; The Journal of Neuroscience, October 15, 1998, 120):8417–8422

Ethcathinone is closely related to mephedrone and causes many side effects: Stroke, Psychosis, Pulmonary hypertension, Tachycardia, hypertension, arrhythmia, chest pain, Bone marrow depression, agranulocytosis, leukopenia, Rash, hives, alopecia, ecchymosis, impotence, dizziness, anxiety, headache, mental depression, seizures, Nausea/vomiting, constipation, abdominal cramps, diarrhea.

[top]Mephedrone dose

Oral: 100-250 mg with a duration of ~2 hours
Insufflated: 50-100 mg with a duration of ~1 hour
Never take more than 500mg in 24 hours, as that can lead to hospitalisation or worse.

[top]Mephedrone Appearance

Mephedrone powder:


Mephedrone crystals:

[top]Mephedrone legality

Mephedrone is legal in most countries, but is an analogue of the controlled substance PMMA.

Sweden: has banned Mephedrone after a student died from consumption of mephedrone..
Israel: has banned Mephedrone in 2008, after analysis showed Neorganics products contained Mephedrone.
UK: The AMCD of the UK is looking into Mephedrone and will advice the Home Office on mephedrones legal status. It is to be expected that mephedrone will be banned in the UK.
Finland: Termed a 'medical product' making it illegal to manufacture, import, sell or possess.

[top]Mephedrone history and prevalence

Mephedrone first appeared in the Neorganics product NeoDoves in 2007. This ended in 2008 when the Israeli government banned mephedrone.
Several Chinese producers started to offer mephedrone to research chemical vendors during the spring of of 2008.
In the summer of 2008 Australian police alerted the public that ecstasy tablets with mephedrone where present in Cairns, Australia.
After the ban of BZP in several countries, the popularity of mephedrone has sky-rocketed in 2009. Research Chemical vendors estimate that approximately 6-8 kg mephedrone is sold in Europe per week.(dated June 2009) That is 100.000 - 260.000 doses per month.

[top]Mephedrone degradation

How stable is mephedrone?

[top]Mephedrone files

These documents about Mephedrone are in the file archive
Please add more.

[top]Mephedrone images

Mephedrone pics


Research Chemicals Index - Phenethylamines
Research Chemicals Index - Tryptamines

Reputation Comments on this post:

Great info post, thanks.