Drug info - 4-Methylmethcathinone (2-Methylamino-1-p-tolylpropan-1-one) mephedrone

[Alfa]

Please post info about Mephedrone here.

Please use this thread to add information about:

 

• 1Mephedrone molecule & names
• 2Mephedrone Experiences
• 3Mephedrone dangers & health concerns
  • 3.1Incidents with mephedrone
  • 3.2Mephedrone addiction warning
  • 3.3Mephedrone side effects
• 4Mephedrone pharmacology
• 5Mephedrone dose
• 6Mephedrone Appearance
• 7Mephedrone legality
• 8Mephedrone history and prevalence
• 9Mephedrone degradation
• 10Mephedrone files
• 11Mephedrone images

[top]Mephedrone molecule & names

Names: Mephedrone, p-methylmethcathinone, bk-p-methyl-methamphetamine, 4-MMCIUPAC: 2-Methylamino-1-p-tolylpropan-1-one
Mephedrone should not be confused with Meph (Methyl-Ephedrine)

Mephedrone has been around for a short time and hospitalisations and serious side effects are frequent.

[top]Mephedrone Experiences

Experiences with Mephedrone should be posted here: Mephedrone experiences

[top]Mephedrone dangers & health concerns

Unlike most other research chemicals there are no studies on mephedrone health risks at all. The only data available is empiric (experience reports) and comparing mephedrone to its amphetamine analogue p-MethylMethAmphetamine. Mephedrone has caused deaths.

[top]Incidents with mephedrone

There are several threads that together expose that there is a real danger with mephedrone. An overview be found here:
Mephedrone Experiences & Side-Effects Database

Here are some highlights:

1. Mephedrone: body turned blue with red and purple, limbs numb. URGENT RESPONSE NEEDED!
2. Mephedrone (2-Methylamino-1-p-tolylpropan-1-one) experiences
3. Should swim be worried about extreme cold/freezing on mephedrone?
4. mephedrone is not a toy: Heart problems
5. Mephedrone hospitalization: Purple knees, extremities
6. Mephedrone: Potential Neuropathy - Extreme side effects. PLEASE READ
7. 4-Methylmethcathinone (2-Methylamino-1-p-tolylpropan-1-one) "mephedrone"
8. Mephedrone violent convulsions: hospitalisation
9. mephedrone: felt like his heart was going smash through his rib cage
10. Mephedrone fatigue: heart & breathing problems
11. Help Feeling Mephedrone effects 48+hrs after last dose
12. Teenager dies of mephedrone overdose
13. Possible mephedrone death
14. Mephedrone and amnesia

This drug has caused deaths.

[top]Mephedrone addiction warning

Mephedrone is a very addictive substance. A very high % of users report, that they will not stop before all mephedrone is gone.

[top]Mephedrone side effects

Many users report blueing of the knees & limbs, vasoconstriction, heart problems, breathing problems, convulsions, fatigue, mouth sores. Side effects occur at relatively low doses. Mephedrone has caused deaths.

[top]Mephedrone pharmacology

Not much is known about this widely used drug yet. It has no direct analogs with more information.

Random pharmacological bits and pieces swim came across on the internet: (The second one is about methcathinone but perhaps is relevant)

Pharmacological: 4-Methylmethcathinone is sympathomimetic stimulant. From proposed SAR modelling, 4-methylmethcathinone is expected to have similar pharmacological properties to methcathinone, but with increased activity on the serotonin neurotransmitter systems. Methcathinone is suggested as being more potent than its parent cathinone, and methamphetamine (1) - - - (1) Martin D Schechter; Drug-Drug Discrimination: Stimulus Properties of Drugs of Abuse Upon a Serotonergic-Dopaminergic Continuum; Pharmacology Biochemistry and Behavior Volume 56, Issue 1, January 1997, Pages 89-96

Methcathinone is a drug with a high abuse potential, with prolonged, high dosages known to cause psychosis and withdrawal tremors. Methcathinone is regarded as being similar in profile to methamphetamine in relation to neurotoxicity, with marked decreases in DA levels noted among abstinent users. While generally below levels associated with Parkinsons Disease, this is considered to be demonstrative of permanent, or semi permanent neurological damage (2) - - - (2) Una D. McCann, Dean F. Wong, Fuji Yokoi, Victor Villemagne, Robert F. Dannals, and George A. Ricaurte; Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428; The Journal of Neuroscience, October 15, 1998, 120):8417–8422

Ethcathinone is closely related to mephedrone and causes many side effects: Stroke, Psychosis, Pulmonary hypertension, Tachycardia, hypertension, arrhythmia, chest pain, Bone marrow depression, agranulocytosis, leukopenia, Rash, hives, alopecia, ecchymosis, impotence, dizziness, anxiety, headache, mental depression, seizures, Nausea/vomiting, constipation, abdominal cramps, diarrhea.

[top]Mephedrone dose

Oral: 100-250 mg with a duration of ~2 hours
Insufflated: 50-100 mg with a duration of ~1 hour
Never take more than 500mg in 24 hours, as that can lead to hospitalisation or worse.

[top]Mephedrone Appearance

Mephedrone powder:


Mephedrone crystals:

[top]Mephedrone legality

Mephedrone is legal in most countries, but is an analogue of the controlled substance PMMA.

Sweden: has banned Mephedrone after a student died from consumption of mephedrone..
Israel: has banned Mephedrone in 2008, after analysis showed Neorganics products contained Mephedrone.
UK: The AMCD of the UK is looking into Mephedrone and will advice the Home Office on mephedrones legal status. It is to be expected that mephedrone will be banned in the UK.
Finland: Termed a 'medical product' making it illegal to manufacture, import, sell or possess.

[top]Mephedrone history and prevalence

Mephedrone first appeared in the Neorganics product NeoDoves in 2007. This ended in 2008 when the Israeli government banned mephedrone.
Several Chinese producers started to offer mephedrone to research chemical vendors during the spring of of 2008.
In the summer of 2008 Australian police alerted the public that ecstasy tablets with mephedrone where present in Cairns, Australia.
After the ban of BZP in several countries, the popularity of mephedrone has sky-rocketed in 2009. Research Chemical vendors estimate that approximately 6-8 kg mephedrone is sold in Europe per week.(dated June 2009) That is 100.000 - 260.000 doses per month.

[top]Mephedrone degradation

How stable is mephedrone?

[top]Mephedrone files

These documents about Mephedrone are in the file archive
Please add more.

[top]Mephedrone images

Mephedrone pics


Research Chemicals Index - Phenethylamines
Research Chemicals Index - Tryptamines

Reputation Comments on this post:

	Great info post, thanks.
	Great post with the essentials swimmers should read before taking mephedrone. New info should be added as available. Thi...

[trptamene]

It is p-methyl methcathinone basically. or a bk-anaologue of p-methyl methamphetamine

Reputation Comments on this post:

post helped :)

[Paracelsus]

p-Methyl-methcathinone to be more precise. Sounds like an interesting compound.

Make sure to share experience reports if any are or will be available to you.

Reputation Comments on this post:

Post helped :)

[trptamene]

ahh ya^^ what had meant, thanks for correcting.

[enquirewithin]

There's not much on it except that it may induce short-lived euphoria-- what you would expect of a 'bk.' It would be good to know more....

[Iggypoop]

I'd love to hear SWIMS experiences with this one, sounds pretty good to me.

Here's a post from the old hive:

Some good info there, not sure if i'm allowed to cross post with that stuff though?

[enquirewithin]

Sounds interesting. Can you give us an idea of (a) a single dose and (b) the duration?

This must be: Mephedrone?

[Winta]

Year it is Mephedrone

SWIM is writing a trip rapport atm, with hes friends experiences too Will post it here

[trptamene]

Please post info about Mephedrone here.

Can anyone add information about:

• names / synonyms
• molecule
• dose
• duration
• side effects
• legal status
• have there been any reported incidents with this compound?
• since when has this research chemical been available?
• stability of the molecule / compound

Names: Mephedrone, p-methylmethcathinone, bk-p-methyl-methamphetamine
IUPAC: 2-Methylamino-1-p-tolylpropan-1-one

Experiences with Mephedrone should be discussed here: Experiences - Mephedrone (2-Methylamino-1-p-tolylpropan-1-one) experiences
These documents about Mephedrone are in the file archive
Mephedrone pics
Research Chemicals Index - Phenethylamines
Research Chemicals Index - Tryptamines



Winta, I know you're probably not sure if should post in here thatmunch and am glad edited comments since have personal stake in this....but we are still interested in this compound in and of itself so if you could change the OP to include what i have shown here that will be helpful, I am sure Alfa wouldn't mind the OP being changed...tho should prolly leave other comments edit like they are.

[toe]

Originally Posted by enquirewithin

Likewise. Enthusiasm is fine, but we need some objectivity as well.

Gah! My chambermaid is just about curious enough to argue against that statement by now. DFers are fairly smart, and there are at least a few characteristics of any experience that aren't beholden to subjective experience. Obviously there can be variations due to the presence of other chemicals, size/gender of researcher, but. . . "enthusiasm" can be filtered out if it will offer a starting point for active doses via various MOA for at least one gender of a particular species. . . One would presume that even an "interested" party would not wish to deliberately obscure facts regarding the onset time, duration of action, and relative potency of a compound to anyone whose patronage he'd hope to enjoy repeatedly.* At the very least, it seems, there wouldn't be much room for bias in sharing what class of effect this compound provides (i.e. psychedelic, stimulant, et al)

Just sayin', is all. SWImychambermaid has been curious since this thread was started, and her curiousity upon finding no information accessible to anyone without either a degree in chemistry or the zen-like skills of concentration & self-restraint required to self-teach has only grown.

I hope I'm not being too bothersome here. It's just that my chambermaid has been pestering me and is threatening to cease emptying the pots if she doesn't get *some* kind of information.


*Or the FOAF of a second cousin of the establishment offering this RC, whichever it is.

[enquirewithin]

In due course all will be revealed...

[syntelman]

As "mephedrone" (whoever came up with that name) has been revealed as one of the main ingredients in the products offered from the company selling Neo-Doves/SubCocoas (I'm unsure of the exact product and or names as I have no experience with these products) there should be quite an array of user reports available, and from what I've understood those pills were quite popular. I would be very surprised if it was anything less than quite pleasant.

[Cuberun]

Expect an experience report from SWIM soon.
As a preview, SWIM can confirm that mephedrone is worthwhile and up there with methylone if not better. Santa still needs to experiment some more on his raindeers though.

[Kahless]

Good to hear some more balanced reports after all the hype.

Would SWIM say that like methylone, mephedrone needs around twice the dosage of MDMA?

[enquirewithin]

^That would probably be OK but start lower, although doses are still very much speculation. It should be noted, possibly, that unlike MDMA and amphetamines physical overdose is possible, according to this note from Rhodium.

Apparently ephedrone (the name obviously derived from ephedrine) has been around for some time in Russia, where it has been reported as a drug of abuse. It was known a "Jeff"!

Ephedrone, also referred to by its street name, "Jeff", is 2-methylamino-1-phenylpropan-1-one has become a substantial drug of abuse in the Union of Soviet Socialist Republics (USSR)...

Ephedrone...has been responsible for numerous drug overdose deaths within the USSR,

[Kahless]

But ephedrone is 2-Methylamino-1-Phenylpropan-1-One
mephedrone is 2-Methylamino-1-p-tolylpropan-1-one

A small change in structure can mean very different effects.

Reputation Comments on this post:

	:)
	Nice job clearing that up.

[enquirewithin]

Originally Posted by Kahless

But ephedrone is 2-Methylamino-1-Phenylpropan-1-One
mephedrone is 2-Methylamino-1-p-tolylpropan-1-one

A small change in structure can mean very different effects.

You are, of course right. Hopefully mephedrone is less toxic, but no one has any idea of the LD50 of mephedrone.

[dr ACE]

psudoephedrine is 2-methylamino-1-phenylpropan-1-ol

swim is not a chemistry expert but all these chemicals are structurally very closely related it would be easy to reduce from one to the other

[Psych0naut]

Originally Posted by Kahless

But ephedrone is 2-Methylamino-1-Phenylpropan-1-One
mephedrone is 2-Methylamino-1-p-tolylpropan-1-one

A small change in structure can mean very different effects.

Indeed. Methamphetamine is just ephedrine with a hydrogen atom instead of a hydroxyl functional group. The only difference between the two is the lack of an oxygen atom, but as we all know there is a huge difference in effects between the two. But no research on possible toxicity has been done yet, so these are all speculations.

[Lehendakari]

Originally Posted by ThirdEyeFloond

Since mephedrone = 4-Methylmethcathinone this should come as no surprise

Is that a general consensus? AFAIK is not clear yet.

[ThirdEyeFloond]

Originally Posted by Lehendakari

Is that a general consensus? AFAIK is not clear yet.

Trivialnames like mephedrone easily add confusion, but before the vendor was banned from a danish board I frequent, it was made clear that it is 2-Methylamino-1-p-tolylpropan-1-one he was selling. And this is indeed 4-Methylmethcathinone / para-methylmethcathinone. IIRC the doubt was more on if it was infact mephedrone at all, since the labeling didn't match the molecular structure depicted on the product. (edit: The chemical depicted being N-ethylcathinone).

I stand by that mephedrone is 4-MMC / p-MMC, but what that particular vendor is selling I don't know and frankly don't care.

Reputation Comments on this post:

Excellent, thanks for clearing that up.

[MrG]

Thanks for the info. Although it being an RC there appears to be little known about its pharmacology or any decent HR data.

[enquirewithin]

Originally Posted by ThirdEyeFloond

Trivialnames like mephedrone easily add confusion, but before the vendor was banned from a danish board I frequent, it was made clear that it is 2-Methylamino-1-p-tolylpropan-1-one he was selling. And this is indeed 4-Methylmethcathinone / para-methylmethcathinone. IIRC the doubt was more on if it was infact mephedrone at all, since the labeling didn't match the molecular structure depicted on the product.

I stand by that mephedrone is 4-MMC / p-MMC, but what that particular prick is selling I don't know and frankly don't care.

2-Methylamino-1-p-tolylpropan-1-one seems to be associated with the name 'mephedrone' by a vendor, it seems perhaps incorrectly. It's passing similarity with 'methylone' (also a misnomer) could be a reason to use that name.

[ThirdEyeFloond]

Originally Posted by enquirewithin

2-Methylamino-1-p-tolylpropan-1-one seems to be associated with the name 'mephedrone' by a vendor, it seems perhaps incorrectly. It's passing similarity with 'methylone' (also a misnomer) could be a reason to use that name.

Ya SWIM agrees that this kind of naming was spawned by methylone. He would have prefered if 4-MMC or p-MMC had catched on instead.

[Paracelsus]

The name "mephedrone" was logical (methyl-ephedrone, ephedrone being a name for methcathinone) and probably not just coined to resemble "methylone."