Drug info - Tiocolchicoside

[Ale]

Anybody knows/has any info about this compoud called Tiocolchicoside, classified as a muscle-relaxant ?Is there any brand-name-medication (or even the generic) , where you are, containing this cetrally/peripherally-acting compound? Could it be compared to something like...say Carisoprodol (trade name Soma®) and/or Cyclobenzaprine (trade name Flexeril® in the US) or any other known muscle-relaxant and therefore be considered as an equivalent alternative to them..?If not..which one would be your Muscle-Relaxant of Choice and why?

[fnord]

not much info is available on this,about all i found:
Originally Posted by Syr
Dr.D, what about tiocolchicoside?
I took 8mg ED for a couple weeks when i had a problem with my shoulded and helped a bit. I had no sides.
It's an interesting compound. It has antagonistic activity at the GABA sub A receptor so it may elevate cortisol but will result in little sedation. Half-life is ~7hr. If you use 8mgs for a few wks, that shouldn't generate too many sides.

[Jatelka]

There's an awful lot of info out there if any marmosets speak Italian!

[Ale]

All I could find says that it's a centrally/peripherally-acting compound that relaxes the skeletal muscles and it's therefore used for the same treatments that other,wide-known M-R are meant for. They are given to relieve the discomfort of muscle spasm or involuntary muscle contracture and also in cases of surgery to relax muscles and provide easier access for the surgeon.

Also..it says that it seems to work both directly on the muscle cell, affecting the sarcoplasmic reticulum within the cell, and centrally :by depressing the CNS and therefore resulting in a mild sedative effect.
That's pretty detailed info but it just doesn't answer the question I was asking myself..and that's why I posted this thread..to see if anyone had some experience with more than one of those substances so to be able to make comparisons or give a preferece about their effectiveness.

[Zaprenz]

You may find the attached article on tiocolchicoside interesting.

Seems to suggest GABAaR antagonist properties - I.e convulsant properties (epileptogenic), not good in other words.

Reputation Comments on this post:

	keep up teh good work.
	Good Find!

[Zaprenz]

also these two articles attached...