Drug info - Methylone Information/Basics

[JDreaming]

Can anyone add information about Methylone, such as

• names / synonyms
• molecule
• dose
• duration
• side effects
• legal status
• have there been any reported incidents with this compound?
• since when has this research chemical been available?
• stability of the molecule / compound

This drug is also known as bk-MDMA, M1, MDMCat, and 3,4-methylenedioxymethcathinone.

Experiences with Methylone should be posted here: Experiences - Methylone Experiences.

These documents about Methylone are in the file archive
Methylone pics
Research Chemicals Index - Tryptamines
Research Chemicals Index - Phenethylamines

Other useful links:

Methylone Health Problems Discussion
Methylone Legality Discussion
Methylone Research Discussion
Methylone Comedown Discussion
Methylone Sublingual Administration
Methylone Intranasal Administration

Reputation Comments on this post:

good info!

[trptamene]

With the alkyl-ones Alfa has been incorporating the beta-keto nomenclature into the thread titles in parenthesis like this: Drug info - Ethylone (bk-MDEA)

Can you add a link to the archive search please?
These documents about methylone are in the file archive
I believe Alfa requests these be added to both the drug info and experience dedicated threads. He specifically mentions drug info threads, but it should be added to both.

If you are unclear on how to do this, PM me and I can give you more details.

Thank you for stepping up and making some of these threads, having to make these threads really slows down the process of me adding molecules for these drugs.


Back on topic:

IUPAC: 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one
Other names: Explosion, Ease, M1

[Iggypoop]

Personally SWIM usually takes a 250mg dose, this can be too much for new users, i hear people take anything from 150mg-350mg, i think it was shulgin who said it was 1/3 the potency of MDMA, don't quote me on that though.

[Benga]

this has been discussed before. swim's wombat finds anything over 300mg to be overdoing it, not that it feels too strong or unpleasant, strong rushes and a little amnesia- but the comedown is steeper, feels quicker- one feels "abandoned" by the substance quicker. and the next day is quite hard in an "i don't want to do anything" emptiness.
150mg feels light, not overwhelming, at 200mg it begins to be an experience in itself.
250mg is a good dose for swim. 150mg to 200mg might be good for a first taste.

what swim finds fascinating in M1 is its ability in helping to break old habits- the next couple of days after an experience, swim finds it very easy to change his routine, little things, not strong addictions, the kind of things one settles into doing repetedly. other friends have noticed this also, might be just related to serotonine depletion or actually a rather positive side effect of this substance's experience.
b

Reputation Comments on this post:

Thanks for sharing.

[trptamene]

Considering tramadols SNRI activity effect on an MDMA experience, and the fact that it basically renders the substance inactive from a recreational standpoint...would the same kind of drug interaction be seen in this substance? This would probably be good for many swimmers to know before dosing just to learn later was a waste of hard earned $$.

[Bajeda]

Metabolism of the recently encountered designer drug, methylone, in humans and rats

Methylone [2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one; Figure 1], the -ketone analogue of 3,4-methylenedioxymethamphetamine (MDMA), increases the concentrations of monoamine neurotransmitters such as serotonin, dopamine and noradrenaline in the human synaptic cleft through inhibition of plasma membrane monoamine reuptake transporters (Cozzi et al. 1998, 1999). This increase results in stimulation of the central nervous system and hallucinogenic effects (Dal Cason et al. 1997).

The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat

Phenethylamine derivatives were also assayed for their ability to release dopamine, 5-HT, and norepinephrine (Table 3 and Fig. 1). Methylone was one of the strongest releasers of our tested chemicals; the EC50 values were 3.8 x 10-7 for dopamine, 2.2 x 10-7 for 5-HT and 9.3 x10-8 M for norepinephrine.

Of the tested chemicals, methylone had the most extensive effects on monoamine re-uptake and release of the MDMA analogues examined, and BDB and MBDB also strongly affected the monoaminergic neurotransmission systems. MDMA analogues had less effect on dopaminergic systems than methamphetamine; however, their action on serotonergic neurotransmission was stronger than that of the positive control, methamphetamine.

I think it would be a good idea to avoid methylone until swiy is sure that the SSRI/SNRI effects of Tramadol have dissipated.

Reputation Comments on this post:

	Thanks for adding this info.
	Thanks for the info.

[CrakkBakk]

Any other dosing for this?

Sounds way too expensive for the dose. I gram only lasts a person 4 times? Thats aLOT of money.

Reputation Comments on this post:

please be more clear about what you mean.

[dark12]

Wow,
What has SWIM been missing? SWIM is going to be putting a lot of time into learning about these chemicals soon. It all seems so confusing... SWIM thinks this will be the first RC he experiments with since he finds MDMA to be the most interesting out of everything he has experienced.
Thanks much for the info!

[bLuE]

swim heard that methylone is a smoother ride than MDMA, more chill, does it still have the stimulation and increased motor function of its amph-sister?

[spacca]

SWIM tells me that methylone is his favoured RC of the moment. He tried it together with Mephedrone, having discovered them at the same time. His initial doses were 150-200mg per hit. After several experiments he decided Mephedrone was too plasticky in it's experience - bit hard too describe, but whereas the Methylone experience is a very pleasant one, the mephedrone always seemed to be a little toxic feeling.
So, after trying various experiements and combinations, SWIM has decided that Methylone, henceforth referred to as M1, is the RC of choice. He also discovered that reducing dosages to 30-50mg at 1-2 hour intervals provided a suprisingly effective experience. The first dose has almost no effect, but then following up with the second starts the ball rolling. This obviously helps with the cost too.
Fiending is an issue with M1 but dosing at this level helps, keeping it a nice roll rather than getting too wired.
SWIM also stated that when he does get a little too wide awake when he really should be sleeping, alcohol negates the effect of the M1 and he sleeps like a baby. He was trying chamomile tea, but this resulted in a trip to the loo every half an hour for about 4-5 hours and not brilliant sleep....not quite sure why....
Several of SWIMs aquaintances have had adverse affects with mephedrone, including one hospitalisation with heart problems......he hasn't heard of any problems on this scale with M1 to date, so believes his initial instinct is probably accurate....not very scientific he knows but.....

Reputation Comments on this post:

informative report - thank you for posting it, and following the rules as a newbie!

[10outof10]

Would SWIM have any recommendations for safe amount to do within one session? Understand that large quantities of mephedrone within one session can have risks of nasty side effects just wondered if the same could be said for M1. Like above, SMIM has heard that M1 is a more mellow experience. Have also heard for newbies 150mg would be sufficient. Curious to know if dry mouth also an issue with M1 as it is with mephedrone?

[Cuberun]

SWIM always ends up using 1g in a session. This is what's apparantly safe for him though. He takes a lot of supplements, is healthy and trains cardio everyday. He monitors his heartrate and there's nothing out of the ordinary.

What is safe for someone else may not be safe for swiy.

[10outof10]

Thanks for the info..does SWIM notice anything like the mephedrone dry mouth or any other effects that are different from other stimulants that are worth mentioning? Thanks in advance

[Cuberun]

Not really.. swim doesn't get dry mouth or jaw clenching.. he supplements with 750-1000mg magnesium though and always stays well hydrated..

[Frogster]

Originally Posted by JDreaming

Can anyone add information about Methylone, such as

• names / synonyms
• molecule
• dose
• duration
• side effects
• legal status
• have there been any reported incidents with this compound?
• since when has this research chemical been available?
• stability of the molecule / compound

According to Swim, if done correctly, Methylone is the Nr1 MDMA substitute.

Dose: Swim doesn't like to go over 400mg in a session. First 200mg oral dissolved in multi-vitamin juce. Repeat 20 min after the peak.

Preloading: Being well rested and fed without a full stomach. Dietary supplements: Tryptophan or 5-HTP. Pharms: Piracetam 1.6g - 3.2g (it works!).

Postloading: isotonic drinks, energy drinks, sweet/salty snacks, Magnesium, Tryptophan or 5-HTP, Mannitol, antioxidans, vitamins. In case of unconfortable comedown: Kratom, GHB or Benzodiazepines. Do not redose M1 on uncomfortable comedown!

Duration (approx.): Onset t+0:20, Peak t+0:30, Plateau t+0:50, Comedown t+2:30, Baseline t+5:00

Side effects: Nystagmus (occasional), sweating (occasional), dirty comedown including bruxism, stiff muscles, agitation anxiety ect. (occasional). Most side effects can be avoided with appropriate Pre/Postloading.

Swim doesn't know of any incidents relating M1.

Methylone has been available around 2005 and has grown in popularity around 2008. It is still uncontrolled in most countries. If stored in a dark dry place, M1 remains fully active after more than 2 years.

General advice: Don't do Methylone while on Anti Depressants, they will destroy the roll (SSRI's) or lead to hospital (MAOI's). Do Methylone rarely (on special occasions). Share with good friends. Never drink a lot of alkohol before doing M1. Reasonable quantities of alcohol while rolling are ok. Don't forget to hydrate. Have Benzos nearby, just in case. Snorting means wasting good M1. Btw, 400mg is a lot, Swim would suggest 200mg for first timers.

Reputation Comments on this post:

Very good gideline for M1 beginners

[Guigz]

Swim didn't find anything about this when he UTSE.
And he don't know if he post in the appropriate thread.

Any interaction between tramadol and mephedrone?
If swim took 400mg of xr tramadol, when he can consume some mephedrone?

EDIT: I mean METHYLONE, of course. Sorry.

Reputation Comments on this post:

This thread is discussing Methylone not Mephedrone.

[Maxfrombx]

Originally Posted by Guigz

Swim didn't find anything about this when he UTSE.
And he don't know if he post in the appropriate thread.

Any interaction between tramadol and mephedrone?
If swim took 400mg of xr tramadol, when he can consume some mephedrone?

No one can give SIWY a clear answer, as SWIY might have already guessed. 400mg tramadol is the seizure threshold risk. XR may lower the risk. Adding a dopaminergic/serotoninergic stimulant on the top of the SSRI action of tramadol is up to SWIY. Even the best neurophysiologist wouldn't be able to predict the interaction. Tramadol in itself is like a baby speedball. Start with low doses.