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Beta-Ketones Mephedrone, Methylone, Butylone, Methedrone, Ethcathinone, 3-fluoroMethCathinone (3FMC), Methylenedioxypyrovalerone (MDPV)

 
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  #1  
Old 14-11-2007, 00:52
JDreaming Gold member JDreaming is offline
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Methylone (3,4-methylenedioxymethcathinone, bk-MDMA) Drug Info

Please post info about methylone here.

Can anyone add information about:
  • names / synonyms
  • molecule
  • dose
  • duration
  • side effects
  • have there been any reported incidents with this compound?
  • since when has this research chemical been available?
  • legal status
  • stability of the molecule / compound
Experiences with methylone are discussed in the following thread: Methylone Experiences

_____________________________________

Trivial Name: Methylone
Synonyms: 3,4-methylenedioxymethcathinone, bk-MDMA, β-keto-MDMA, methylenedioxymethcathinone
IUPAC Name: 1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one
Molecular Formula: C11H13NO3
Molecular Mass: 207.2 g/mol



Legal status in US: Schedule I controlled substance under federal law as a result of an emergency scheduling order. Legality under state law will vary depending on the specific legislation enacted in each US state.

Legal status in Canada: Unconfirmed.

Legal status in UK: Class B controlled substance under the Misuse of Drugs Act 1971, order 2010.

Legal status in the Republic of Ireland: Schedule 1 controlled substance under the Misuse of Drugs Act 1977.

Legal status in Australia: Unconfirmed.

Research Chemicals Index - Beta-Ketones
Research Chemicals Index - Tryptamines
Research Chemicals Index - Phenethylamines
Research Chemicals Index - Synthetic Cannabinoids
Research Chemicals Index - Piperazines
The Research Chemical Index

_____________________________________
(end mod edit)

Other useful links:

These documents about Methylone are in the file archive
Methylone pics
Methylone Health Problems Discussion
Methylone Legality Discussion
Methylone Research Discussion
Methylone Comedown Discussion

Methylone Sublingual Administration
Methylone Intranasal Administration

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good info!

Last edited by Phenoxide; 09-09-2012 at 18:16. Reason: standard drug info thread format
  #2  
Old 14-11-2007, 01:27
trptamene trptamene is offline
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Re: Methylone Information/Basics

With the alkyl-ones Alfa has been incorporating the beta-keto nomenclature into the thread titles in parenthesis like this: Drug info - Ethylone (bk-MDEA)

Can you add a link to the archive search please?
These documents about methylone are in the file archive
I believe Alfa requests these be added to both the drug info and experience dedicated threads. He specifically mentions drug info threads, but it should be added to both.

If you are unclear on how to do this, PM me and I can give you more details.

Thank you for stepping up and making some of these threads, having to make these threads really slows down the process of me adding molecules for these drugs.


Back on topic:

IUPAC: 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one
Other names: Explosion, Ease, M1
Attached Images
File Type: jpg methylone.JPG (10.7 KB, 103 views)

Last edited by trptamene; 14-11-2007 at 01:38.
  #3  
Old 12-02-2008, 19:25
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Re: Methylone Dosages

Personally SWIM usually takes a 250mg dose, this can be too much for new users, i hear people take anything from 150mg-350mg, i think it was shulgin who said it was 1/3 the potency of MDMA, don't quote me on that though.
  #4  
Old 12-02-2008, 19:39
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Re: Methylone Dosages

this has been discussed before. swim's wombat finds anything over 300mg to be overdoing it, not that it feels too strong or unpleasant, strong rushes and a little amnesia- but the comedown is steeper, feels quicker- one feels "abandoned" by the substance quicker. and the next day is quite hard in an "i don't want to do anything" emptiness.
150mg feels light, not overwhelming, at 200mg it begins to be an experience in itself.
250mg is a good dose for swim. 150mg to 200mg might be good for a first taste.

what swim finds fascinating in M1 is its ability in helping to break old habits- the next couple of days after an experience, swim finds it very easy to change his routine, little things, not strong addictions, the kind of things one settles into doing repetedly. other friends have noticed this also, might be just related to serotonine depletion or actually a rather positive side effect of this substance's experience.
b

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Thanks for sharing.
Very nice
  #5  
Old 12-02-2008, 21:04
trptamene trptamene is offline
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Re: Methylone Information/Basics

Considering tramadols SNRI activity effect on an MDMA experience, and the fact that it basically renders the substance inactive from a recreational standpoint...would the same kind of drug interaction be seen in this substance? This would probably be good for many swimmers to know before dosing just to learn later was a waste of hard earned $$.
  #6  
Old 13-02-2008, 00:36
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Re: Methylone Information/Basics

Metabolism of the recently encountered designer drug, methylone, in humans and rats

Quote:
Methylone [2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one; Figure 1], the -ketone analogue of 3,4-methylenedioxymethamphetamine (MDMA), increases the concentrations of monoamine neurotransmitters such as serotonin, dopamine and noradrenaline in the human synaptic cleft through inhibition of plasma membrane monoamine reuptake transporters (Cozzi et al. 1998, 1999). This increase results in stimulation of the central nervous system and hallucinogenic effects (Dal Cason et al. 1997).



The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat

Quote:
Phenethylamine derivatives were also assayed for their ability to release dopamine, 5-HT, and norepinephrine (Table 3 and Fig. 1). Methylone was one of the strongest releasers of our tested chemicals; the EC50 values were 3.8 x 10-7 for dopamine, 2.2 x 10-7 for 5-HT and 9.3 x10-8 M for norepinephrine.
Quote:
Of the tested chemicals, methylone had the most extensive effects on monoamine re-uptake and release of the MDMA analogues examined, and BDB and MBDB also strongly affected the monoaminergic neurotransmission systems. MDMA analogues had less effect on dopaminergic systems than methamphetamine; however, their action on serotonergic neurotransmission was stronger than that of the positive control, methamphetamine.


I think it would be a good idea to avoid methylone until swiy is sure that the SSRI/SNRI effects of Tramadol have dissipated.

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Thanks for adding this info.
Thanks for the info.
  #7  
Old 13-02-2008, 04:29
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Re: Methylone Information/Basics

Any other dosing for this?

Sounds way too expensive for the dose. I gram only lasts a person 4 times? Thats aLOT of money.

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please be more clear about what you mean.
  #8  
Old 27-12-2008, 18:24
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Re: Methylone Information/Basics

Wow,
What has SWIM been missing? SWIM is going to be putting a lot of time into learning about these chemicals soon. It all seems so confusing... SWIM thinks this will be the first RC he experiments with since he finds MDMA to be the most interesting out of everything he has experienced.
Thanks much for the info!
  #9  
Old 19-10-2009, 01:37
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Re: Methylone Information/Basics

swim heard that methylone is a smoother ride than MDMA, more chill, does it still have the stimulation and increased motor function of its amph-sister?
  #10  
Old 25-10-2009, 19:18
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Re: Methylone Information/Basics

SWIM tells me that methylone is his favoured RC of the moment. He tried it together with Mephedrone, having discovered them at the same time. His initial doses were 150-200mg per hit. After several experiments he decided Mephedrone was too plasticky in it's experience - bit hard too describe, but whereas the Methylone experience is a very pleasant one, the mephedrone always seemed to be a little toxic feeling.
So, after trying various experiements and combinations, SWIM has decided that Methylone, henceforth referred to as M1, is the RC of choice. He also discovered that reducing dosages to 30-50mg at 1-2 hour intervals provided a suprisingly effective experience. The first dose has almost no effect, but then following up with the second starts the ball rolling. This obviously helps with the cost too.
Fiending is an issue with M1 but dosing at this level helps, keeping it a nice roll rather than getting too wired.
SWIM also stated that when he does get a little too wide awake when he really should be sleeping, alcohol negates the effect of the M1 and he sleeps like a baby. He was trying chamomile tea, but this resulted in a trip to the loo every half an hour for about 4-5 hours and not brilliant sleep....not quite sure why....
Several of SWIMs aquaintances have had adverse affects with mephedrone, including one hospitalisation with heart problems......he hasn't heard of any problems on this scale with M1 to date, so believes his initial instinct is probably accurate....not very scientific he knows but.....

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informative report - thank you for posting it, and following the rules as a newbie!
totally agree on all points. SWIM's had problems with mephedrone similar to the ones mentioned, and finds methylone way easier on the old ticker
  #11  
Old 26-10-2009, 10:06
10outof10 Gold member 10outof10 is offline
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Re: Methylone Information/Basics

Would SWIM have any recommendations for safe amount to do within one session? Understand that large quantities of mephedrone within one session can have risks of nasty side effects just wondered if the same could be said for M1. Like above, SMIM has heard that M1 is a more mellow experience. Have also heard for newbies 150mg would be sufficient. Curious to know if dry mouth also an issue with M1 as it is with mephedrone?
  #12  
Old 26-10-2009, 15:45
Cuberun Gold member Cuberun is offline
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Re: Methylone Information/Basics

SWIM always ends up using 1g in a session. This is what's apparantly safe for him though. He takes a lot of supplements, is healthy and trains cardio everyday. He monitors his heartrate and there's nothing out of the ordinary.

What is safe for someone else may not be safe for swiy.
  #13  
Old 26-10-2009, 15:48
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Re: Methylone Information/Basics

Thanks for the info..does SWIM notice anything like the mephedrone dry mouth or any other effects that are different from other stimulants that are worth mentioning? Thanks in advance
  #14  
Old 26-10-2009, 17:09
Cuberun Gold member Cuberun is offline
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Re: Methylone Information/Basics

Not really.. swim doesn't get dry mouth or jaw clenching.. he supplements with 750-1000mg magnesium though and always stays well hydrated..
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Old 27-10-2009, 17:24
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Re: Methylone Information/Basics

Quote:
Originally Posted by JDreaming View Post
Can anyone add information about Methylone, such as
  • names / synonyms
  • molecule
  • dose
  • duration
  • side effects
  • legal status
  • have there been any reported incidents with this compound?
  • since when has this research chemical been available?
  • stability of the molecule / compound

According to Swim, if done correctly, Methylone is the Nr1 MDMA substitute.

Dose: Swim doesn't like to go over 400mg in a session. First 200mg oral dissolved in multi-vitamin juce. Repeat 20 min after the peak.

Preloading: Being well rested and fed without a full stomach. Dietary supplements: Tryptophan or 5-HTP. Pharms: Piracetam 1.6g - 3.2g (it works!).

Postloading: isotonic drinks, energy drinks, sweet/salty snacks, Magnesium, Tryptophan or 5-HTP, Mannitol, antioxidans, vitamins. In case of unconfortable comedown: Kratom, GHB or Benzodiazepines. Do not redose M1 on uncomfortable comedown!

Duration (approx.): Onset t+0:20, Peak t+0:30, Plateau t+0:50, Comedown t+2:30, Baseline t+5:00

Side effects: Nystagmus (occasional), sweating (occasional), dirty comedown including bruxism, stiff muscles, agitation anxiety ect. (occasional). Most side effects can be avoided with appropriate Pre/Postloading.

Swim doesn't know of any incidents relating M1.

Methylone has been available around 2005 and has grown in popularity around 2008. It is still uncontrolled in most countries. If stored in a dark dry place, M1 remains fully active after more than 2 years.

General advice: Don't do Methylone while on Anti Depressants, they will destroy the roll (SSRI's) or lead to hospital (MAOI's). Do Methylone rarely (on special occasions). Share with good friends. Never drink a lot of alkohol before doing M1. Reasonable quantities of alcohol while rolling are ok. Don't forget to hydrate. Have Benzos nearby, just in case. Snorting means wasting good M1. Btw, 400mg is a lot, Swim would suggest 200mg for first timers.

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Very good gideline for M1 beginners
Informative post, valuable info on mixing M1
Excellent post. Clear, concise and informative
Good information
Very good "starting out" info

Last edited by Frogster; 27-10-2009 at 17:49. Reason: adding for completeness
  #16  
Old 31-10-2009, 08:31
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Re: Methylone Information/Basics

Swim didn't find anything about this when he UTSE.
And he don't know if he post in the appropriate thread.

Any interaction between tramadol and mephedrone?
If swim took 400mg of xr tramadol, when he can consume some mephedrone?

EDIT: I mean METHYLONE, of course. Sorry.

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This thread is discussing Methylone not Mephedrone.

Last edited by Guigz; 20-11-2009 at 14:41.
  #17  
Old 01-11-2009, 03:00
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Re: Methylone Information/Basics

Quote:
Originally Posted by Guigz View Post
Swim didn't find anything about this when he UTSE.
And he don't know if he post in the appropriate thread.

Any interaction between tramadol and mephedrone?
If swim took 400mg of xr tramadol, when he can consume some mephedrone?
No one can give SIWY a clear answer, as SWIY might have already guessed. 400mg tramadol is the seizure threshold risk. XR may lower the risk. Adding a dopaminergic/serotoninergic stimulant on the top of the SSRI action of tramadol is up to SWIY. Even the best neurophysiologist wouldn't be able to predict the interaction. Tramadol in itself is like a baby speedball. Start with low doses.
  #18  
Old 26-11-2009, 14:02
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Re: Methylone Information/Basics

How often are SWIY using methylone? Is 300-500mg every 3 weeks too much?
  #19  
Old 26-11-2009, 19:46
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Re: Methylone Information/Basics

That sounds very reasonable! SWIM tends to use 100-400mg per 'trip' (depending on whether he's staying in with tunes and the internet, or going out clubbing) and he does it two or three times a week (although it's dropping off a little now). So once every two-three weeks should be fine!

Regards redosing: SWIM has found that Tamis's advice to redose with the same (or slightly higher) than the original dose, but about 1.5 hrs after the initial dose, works best for him. Try experimenting with different amounts at different intervals to see what suits SWIY. It seems to vary from person to person. Search the forum for methylone + redose and see what comes up!

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  #20  
Old 05-12-2009, 17:37
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Re: Methylone Information/Basics

I would not use entactogens more often than once every two or three months to avoid neurotransmitter depletion.

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You sound pretty stupid making this kind of generalization in a one line post. You should be more specific
Thanks for contributing but could you elaborate a little?
goo harm reduction advice
  #21  
Old 17-01-2010, 14:09
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Re: Methylone (2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one) Information/Ba

Why does snorting waste it?
A couple of times when SWIM has snorted it SWIM has woken up the next morning and accidentally sniffed some of the residue left in his nose, which is strange, and is it normal to feel like you have a cold?
  #22  
Old 17-01-2010, 15:58
Felix Machina Felix Machina is offline
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Re: Methylone (2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one) Information/Ba

Blow your nose after a session

Methylone is never talked about on the drug scene here, always mephedrone. Will Methylone provide a new experience for SWIM and his fellow swimmers, would methylone go well for a big night at a club on the first time like mephedrone did?
  #23  
Old 19-01-2010, 17:15
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Re: Methylone (2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one) Information/Ba

SWIM would agree with what has previously said (don't think it's in this particular thread) that Methylone seems a bit more cleaner then Mephedrone, can't really explain it, and could be under different situations but there seems to be less ill-effects after with Methylone in SWIM's opinion
  #24  
Old 16-02-2010, 01:39
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Re: Methylone Dosages

Quote:
Originally Posted by Benga View Post
what swim finds fascinating in M1 is its ability in helping to break old habits- the next couple of days after an experience, swim finds it very easy to change his routine, little things, not strong addictions, the kind of things one settles into doing repetedly. other friends have noticed this also, might be just related to serotonine depletion or actually a rather positive side effect of this substance's experience.
b
swim has also experienced this, aswell as a lasting confidence even days after a methylone or methedrone experience. swim usually sleeps before comedown sets in fully but awakes refeshed although a little dazed but with double swims day to day confidence (swim is usually a rather timid creature otherwise) has anybody's monkey experienced anything like this?

Last edited by Benga; 16-02-2010 at 07:26.
  #25  
Old 01-03-2010, 21:29
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Re: Methylone (2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one) Information/Ba

From what swims gathered from other people, 100-200mg is a good dose to begin with? Swims ordered 5g's of lone for a heavy weekend.
How often would one usually redose? And how much for each redose? and how many redoses is considered safe?

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Avoid using ambiguous slang names such as "lone"

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Opinions - Drug Policy Debate: Helpful Links / Sources of Information Bajeda Drug Policy Reform & Narco Politics 12 05-06-2009 13:12
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