losing effects after 2-3 hours?

[pyschidelicmann]

ok well i took 20mg IR adderall about 5 hours ago. i used it for some schoolwork but i was a little dissapointed because ive realized that when i take adderall lately (IR), i get really hyper and talkative and normal adderall effects, until about 2 or 3 hours later, then i just feel sorta tired, yet sorta feeling it inside. definately not the motivation and energy i had before. when i used to take it i could feel like that almost all day, now its just 2 or 3 hours. what happened? how can i make it stay like that how it used to?

i have XR, that just lasts too long sometimes, which is why i use IR if i take it after noon or so.

i thought it might be a tolerance issue, but i havent taken it in 4-5 weeks so i dont think that would be a factor?

any help?

thanks

[candy_kid]

it could very well be some form of tolerance, tho its hard to say as noone is completely sure how the entire mechanism works... but here's a brighter possibility that swim noticed, food. swim finds that the initial burst of amphetamine suppresses appetite and increases energy to a point where food almost seems pointless, things feel great, but then if food hasn't been eaten 2-3 hours after it kicks in he feels quite rough. However, if food has been eaten he feels great for the last hour or two and long into sobriety -- give it a shot and see how it goes.

[jazzmetalguitar]

what did SWIY eat? what did SWIY drink? etc etc.

drug absorption has many factors...

[angela20377]

swim agrees with swicandykid, she finds thats whether its IR or XR, eating food like pasta or maybe something a little heavier makes her feel the adderall effects more strongly. sometimes it sucks trying to find something that sounds appetizing but its worth it for swim.

[pyschidelicmann]

well when i was doing work, i had chex mix and milk. but isnt milk a base right? so that wouldnt do anything.

[realitybias]

Please observe the forum rules and use SWIM. Avoid self-incrimination.

Adderall will not be good for everyone all the time, and adderall does not make oneself into "God" and give oneself godlike understanding of any subject matter. Hard subject matter is still hard, a lesson that SWIM had to learn when he began his treatment. It may not be the medicine, although tolerance can certainly be an issue if SWIY changed from XR to IR. It may be SWIYs lifestyle, how well SWIY is eating, how well SWIY's liver and kidneys are functioning, and what vitamins are taken.

As for tolerance, if that is the issue, its dopamine tolerance. SWIY may be interpreting the lack of that warm feeling at the base of the head with adderall not working. Just keep plugging away, adderall takes a while to completely stop working for most people. If its tiredness SWIY struggles with, consider supplementing SWIY's intake with modafinil.

[candy_kid]

milk is actually slightly acidic btw and keep in mind that a bowl of cereal isn't enough food to get someone through the day-- adderall takes the automatic out of eating; you have to consciously think every couple of hours to eat a meal

@realitybias : I dont get how tolerance could be an issue based on switching from XR to IR? Wouldn't that more be a different dose than one is used to issue?

[jazzmetalguitar]

^^^candy_kid is very correct pertaining to the switch from XR to IR. If these are the same dosages (i.e. 30XR -> 30IR), then serum levels of amphetamine will be higher at any given moment.

[candy_kid]

interesting- a reply to an old thread I was subscribed to made me reread an old post of mine with a quote that might help push the acid/base theory of sped up tolerance

the quote again from another forum's respected member fastandbulbous talking about reducing acidity with basic foods : "It slows clearance of amphetamine by the kidneys because less amphetamine in blood plasma is present as a salt (it's the ionized/salt form that gets max clearancve by the kidneys)"

so it almost seems like amphetamines last longer with low acidity rather than just increasing the absorption as most people point out- this seems to run in line with the problem swiy was having, although keep in mind that keeping the body's actual energy levels up with enough nourishment can definitely be a factor too!

some acidic foods that most people I'm sure would think basic or neutral (I would have if I didn't do some searching) are meat, milk products, fish, and apparently even distilled water (pure distilled water is neutral, but according to the internet [trust at your own risk] the stuff in stores is often acidic for some reason) -- reducing those + the usual foods (or adding tums) while taking food breaks would probably be smart in diagnosing this problem. A couple days to replenish natural energy stores might be smart too.

anyway, maybe swiy can follow up if they find something works?

[jazzmetalguitar]

if SWIY checks out my science of dopamine thread there are a bunch of ways to lower acidity listed