Have Adderall xr, want it to last shorter

[mattcose]

SWIM takes it in the morning so it wears off by early evening, but if x need to study x'd like to a take a little more. x have 25mg capsules.
If x was to grind it up completely (following guides) and ingest it, how long would it last before x could go to sleep?
Would drinking something like lemon juice help shorten the effects or simply make them less intense?
Thanks

[angela20377]

it really depends from person to person, but if swiy was to grind it all up, swim would guess that it would last about 4 hours and it would start acting more quickly.
swim would advise against lemon juice or any kind of acetic drinks because for her it just makes the effects less noticeable rather than shorten the length. perhaps swiy could drink a glass or two of orange juice (or whatever acetic thing they want to use) when they want the effects to start slowing down.
this is all theoretical though, as swim personally doesn't ever want to shorten the effects of her precious adderall, haha.
swim is curious, if swiy tries it post a report on how it works if swiy can.

[jazzmetalguitar]

Metabolism of amphetamine is highly dependent on pH levels because amphetamine has a relatively high pKa constant of 9.8-9.9. Now SWIM must explain pKa values the best he can (he is not a chemistry major after all):

Ka = acid dissociation constant or acid ionization constant

We will refer to it as the acid ionization constant because it makes understanding this a bit easier. Now, these values are most often seen described as pKa values because the Ka values range greatly over many different magnitudes and so:

pKa = 10^(Ka)

This thankfully brings the value range into the area of -100 to 100 for extreme cases, though most pKa values are rather between about -10 and 10. Now, we must understand how drugs are absorbed. When taken orally technically drugs can begin absorption in the mouth, this is why LSD and other drugs can be put under the tongue, however most of the absorption occurs in the small intestine. The drug then travels to the liver, being metabolized along the way into other chemicals, and then to the bloodstream.

Well this is where pH and pKa levels have everything to do with absorption and it comes back to that key term ionization. When amphetamines become ionized they a) become more attracted to water and b) become less lipid soluble. So the ionized amphetamine is water-soluble while the non-ionized is lipid soluble. Amphetamine needs to be lipid-soluble to get into important membranes and inversely water soluble to get out. Since it is a base amphetamine will ionize acids and be non-ionized at varying percentages closer to a pH of 9.8 (the pKa level of amphetamine).

So, firstly this can inhibit absorption. If pH levels are high in the duodenum where amphetamine (and most drugs) are absorbed then a higher percentage of amphetamine will be ionized this will inhibit absorption. If inhibited long enough you will lose some of the amphetamine. Result: blood plasma levels are lower and the drug is thus less potent.

More importantly to the thread starter, pKa effects drug elimination. When the amphetamine is traveling through the bloodstream after absorption, acidic urine and an acidic enviroment ionize the amphetamine and speed up bodily elimination of the drug. This results in shorter duration.

Info about amphetamines and pH levels can be found here:
http://www.drugs.com/pro/adderall.html

[fnord]

yes grinding it up would make it last a lil bit shorter seeing as it would all be absorbed at once but you should realize that it would also cause a bigger high/rush more stimulation/ jittery twitches and isn't safe if you have any known or unknown heart conditions/murmurs.i would assume ones doctor would check for these things in the doctors office with a quick EEG/EKG? which ever ones that heart one (sorry im so darn tired)before prescribing an amphetamine but you never know a lot doctors dont.

[mattcose]

Originally Posted by jazzmetalguitar

More importantly to the thread starter, pKa effects drug elimination. When the amphetamine is traveling through the bloodstream after absorption, acidic urine and an acidic enviroment ionize the amphetamine and speed up bodily elimination of the drug. This results in shorter duration.

Info about amphetamines and pH levels can be found here:
http://www.drugs.com/pro/adderall.html

Wow, thanks so much for the explanation! Just one question, when should I drink lemon juice/something acidic? That is, will drinking it with the adderall or a little before shorten the duration, or would I only want to drink some when when I want it be over quickly. For example, if its 7pm and I want to be able to sleep by midnight or 1, would I have something acidic then or closer to 11 or so?
Thanks alot again

[jazzmetalguitar]

Here it would be hard to say because SWIY is trying to get pH level to rise somewhere between when the amphetamine is done being absorbed and the typical time when it begins to become ionized and pulled into urine for elimination. SWIM thinks it completely depends on SWIYs body and how quickly urine is passed after fluid consumption.

It's tricky. SWIM may need some outside advice here if we want to avoid lowering the potency of the drug. It's a lot easier for people who want to increase potency and duration because they simply have to produce alkaline enviroments constantly. SWIM will have to hunt more and maybe get some help.

SWIM also just realized we are talking about adderall XR here. The amphetamine in XRs don't even reach max plasma levels until seven hours, so that has additional possibilities at making this difficult.

Crappy Option: Since SWIY has 25mg, SWIM recalls reading that the slightly diff colors in the beads distinguish the strong-shelled slow-release ones from those that aren't. SWIY probably catches my drift lol...

[mattcose]

Can't find the edit button, so for the record I sometimes refer to my often-inquiring friend Ira as "I" for short.
Was thinking that I could avoid the long lasting effects by soaking the beads in water for an hour or two, using a coffee filter to get out the beads, and then just drink the solution. Would only be the fast acting drugs that "I" would start feeling within the first two hours, no?

[jazzmetalguitar]

The four different salts still have different metabolization rates but, yes, it would result in a shorter overall duration. However, note that adderall is designed so these rates work together to work smoothly. This will cause a more potent rush overall though not quite as high as insufflation because oral doses always have a lower bioavailability.

Now, as far the actual process SWIY described goes. SWIM thinks it'll work but the beads must be crushed. Water's pH will be at the max 7 and even at pH 7 it is 99% or so ionized and therefore very water soluble. Now, something to the effect of a tea strainer may be more effective. Unfortunately, SWIM is unsure how sensitive amphetamines are to heat, doubt they are but keep in mind.

For SWIYs purposes, this tea could work quite well if SWIY threw 1/2 to 1 antacid in the tea and then drank it. This could ensure quick absorption. So then an acid could be drank to make sure it came down when should. Just ranting possibilities though...

SWIM would advise the acid initially with the tea but thinks it may cause an uneven absorption of the isomers and thus a very hilly effect.