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Old 07-11-2007, 23:46
Ya-mon Ya-mon is offline
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Cb-25 & cb-52

2 new cannabinoid analogues I've recently stumbled across.

Quote:
CB-25 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 5.2 and 13 nM, respectively. CB-25 behaves as an inverse agonist for the CB1 receptor as assessed in a cyclic AMP (cAMP) functional assay
Quote:
CB-52 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor with Ki values of 210 and 30 nM, respectively.1 In vitro, CB-52 behaves primarily as a CB1 receptor partial agonist and a CB2 receptor neutral antagonist
In theory should these compounds function like delta-9 THC or another synthetic like CP55,940 that have psychopharmacological effects? Has anyone had any experience with these substances?
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cannabinoids, cb-25, cb-52, synthetic cannabinoids

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