Nicotine as potentiator

[pedosintalgon]

SWIM smokes quite a few cigarettes during his codeine experiences and finds that it somewhat increses the buzz effect (mostly when in the actual proces of smoking it), especialy after the peak has been reached. He did some reaserch on nicotine and found out that in small amounts it acts as a monoamine oxidase (the stuff responsible for braking down dopamine) inhibitor and in larger ones it stimulates the secretion of dopamine. SWIM believes - he's no scientist, any corection will be wellcomed - , dopamine retention is a very good thing while on opiates so he reckons that drinking tea made from 1 or 2 cigs or something like that could potentiate the efect of the opiate aldo he's never had the oportunity to try it out. Your thoughts?

[snooponpanopticism]

All SWIM knows is that it does work. No idea really on the mechanisms behind it. All SWIM knows is the effect as an epiphenomenom; which he sometimes finds so very annoying since he has developed a nicotine addiction as a result of his primary addiction on codein and promethazine. He cannot even stand the smell of smoke when not high. Anyone have any thoughts on effective but healthier substitutes for this problem?....probably just wishful thinking.... never hurts to try though

[Tortoise]

Perhaps Swiy could try nicotine gum?

Swiy has made Swim very curious and he will try this next time he uses codeine. Although, Swim cannot stand smoking. He hates it, so he's gonna try some nicotine gum.

[snooponpanopticism]

Hey Tortoise, thanxs for the tip, it's so simple it's genius!
lets hope it works!

[Skinny]

I dont know what is wrong with people who dont like smokeing, it is one of the best things there are next to solving differential equations, im not sure about making nicotine tea however. I have thought that that can be lethal as the effect of nicotine in a cigarette is directly related to the rate of delivery into the blood stream, im sure a lot of us have heard that some CIA or something used cigarettes as poison. That being said someone told me that smoking on codeine has no noticeable effects, this may be too to a zero tolerance to the nicotine if one were not a regular smoker? ANyways someone mentioned smoking on harder opiates like oxycodone is VERY enjoyable. Someone told me they had a fine time on a nice summer day lying across a sidewalk on a mere 10mg of oxy having smoked a little ganja and having a cigarette listening to music on the ipod was one of the best expeiences of his or her life. Im not sure if the MAOI effects of nic have anything to do with the action of opiates but its possible that they do.

[Skinny]

Originally Posted by Skinny

, this may be too to a zero tolerance to the nicotine if one were not a regular smoker? .

This was meant towards people who did find that there was an effect whereas i heard that normally there is none present with codiene

[Ethyl]

Originally Posted by Skinny

... I have thought that that can be lethal as the effect of nicotine in a cigarette is directly related to the rate of delivery into the blood stream, im sure a lot of us have heard that some CIA or something used cigarettes as poison.

It is one of the best insecticides there is!
Nicotine!

[Ethyl]

Swim got addicted to nicotine because of codeine mostly. It just elevated the high and it tasted so well smoking... After you got a nicotine habit it does little thought.

I think it does the trick by decreasing dopamine recapture time ( wich equals to more dopamine in the synapse = more euphoria), and as you allready have high dopamine levels in the synapses cause of the codeine/opiate the boost would be significant.

Nowadays he is no longer nicotine addicted, and uses mostly his daily cannabis usage as his only smoke to have.. and a much better one.

[samuraigecko]

Half a drop of pure nicotine is lethal, this is what the CIA used/uses. SWIM is a regular smoker and has never experienced any potentiation effects. This may have been because SWIM was already a smoker? dont know. Some sources state that smoking inhibits alot of medications including opiates, unsure on how accurate that is though considering the whole "QUIT SMOKING" policy medical sites and sources have.

[Pino]

Snuff tobacco works too in this case. So it isn't only related to smoking. Probably just the effect of caffeine. It intensify the body buzz -the nice feeling in ones muscles-, while it combats fatigue a bit. My bat says he does this a lot on kratom.

[malsat]

Dopamine dopamine dopamine. Blah Blah Blah.

Nicotine increases the activity of the liver enzyme cyp450 2d6, which is responsible for the conversion of codeine to morphine. SWIM also finds smoking amazing on codeine, which makes sense considering the aforementioned fact.

SWIM also enjoys smoking more on any kind of opiate though, which would suggest some other activity, but this potentiation is much greater with codeine. I would imagine that tobacco also interferes with detoxification mechanisms (glucuronidation? )that dispose of other opiates not dependant on cyp2d6.

But is it worth the cancer, heart disease and emphysema?

[Ethyl]

^^^
I tought nicotine was a 1A2 inducer not 2d6...

And yes, i will stick with the dopamine theory... and is nicotine so addicting in humans? because of dopamine ...

[Melalicious]

codeine + smoking, and MJ, makes for a nice mix according to SWIM who is rather lovely right now


nice site/forum too by the way, my first post keep up the good work

Reputation Comments on this post:

great profile pic

[pedosintalgon]

"and is nicotine so addicting in humans? because of dopamine ..." Heard no, don't remember where dough. I've also heard that nicotine influences dopamine levels significantly only in doses two or three times higher than the 0,3 mg that are actualy inhaled from standard (0,9 mg nic) "red" cigarettes, dus the "cigarette tea" ideea (I don't know why, but the desire to chainsmoke never comes to SWIM on codeine, and I have doubts about its effectiveness given the relatively slow absobtion)Anyway, I've fount the stuff tasting to dubious to take more than one sip.
Some pipe tobbaco is way more powerfull than what you'll find in cigarettes. A few experienced smokers told me it gave them a "strong" feeling. Probably usefull if you have a high nicotine tollerance.

[Archenemy]

SWIM thinks that Nicotine does not potentiate anything. SWIM thinks because Nicotine is a stimulant it will not add to the effect of the opiate either.

But, SWIM does believe that Nicotine increases a high, or makes SWIY/SWIM better. Just like Alcohol. It is a different buzz, but pleasurable all the same.

What does SWIY think?

[Skinny]

SWI-Archenemy makes a good point. I think hes right that probably by far the most significant effect the cigarette has is AS a cigarette; its probably the other way around that the drug subjectively potentiates the cig and makes one realize how great cigarettes really are. That through association one might be inclined to think that the cigarette was enhancing the drug itself.

I have heard that there is a small amount of harmaline in tobacco tho. Maybe potentiates some psychedelics such as DMT possibly? Im pretty sure it doesnt actually chemically potentiate anything like weed for instance...

[JaWill88]

swim uses dip tobacco (grizzly wintergreen) daily and has done so for years. he finds when he uses opioids (well the only one he uses is heroin intravenously) he finds that when he has a dip while on them (although hard because of a dryer mouth) it makes the opioid more intense as he is having his dip. he doesn't think it potentiates so much, more like nicotine justs adds to the buzz.

[Archenemy]

SWIM finds that smoking a "cancer stick" while under the influence of any opiate, more notably Heroin or Morphine, it tastes really good.
Does SWIY find that to be the case also?

As far as adding to the buzz, it seems like a fair few of people think that to be the case.

[darkglobe]

^ Post didn't really say anything did it. =/

SWIM has never noticed any potentiation effects, althought is a regular smoker - and as a few other have said, that probably affects it.

As far as using Nicotine to potentiate Opiates goes, I'd personally say don't do it. That is a subjective opinion, but still.

I'm not certain about Nicotine's status as a MAOI or not (sources tend to contradict themselves), but if it is a MAOI (which, if it helps, I believe it to be) then be careful with it - no matter what drug combination it is, MAOIs can and do have tendencies to screw you up.