Experiences - Diphenyl-2-Pyrrolidinyl-Methanol (diphenylprolinol) trip reports

[Rush]

somebody tried sublingual admin? cause SWIM don't feels like 'plugging' !

after those extensive experimentation which would be the optimal oral dosage?


something of concern - up to 2 days post admin, reported feelings of baseless anger, coming in bursts about every 2 hours. this in no way resembled any hitherto experienced 'comedown' effects and was not even attributed to such until it became obvious.

--->that's weird!other comedown sintoms? like lethargia or depression?

[radiometer]

Originally Posted by nanobrain

seems dosing / delivery strategy is most important with this substance.

smoking is not viable, neither is insufflation and for what its worth, the ratties found oral dosing virtually worthless.

So, barring exotic options, you've pretty much left only rectal admin and injection. Any theory as to how this stuff might be worth bothering taking? Could you elaborate on why insufflation and smoking are not viable? Thanks!

Mini-report:

SWIM gave some of this compound to a friend. Subject took it at midnight before going to a party, and was very tired after having gotten up at 4 am that morning. I believe subject took about 20-30mg orally, but not positive. Subject reported feeling very awake and in a good mood throughout the night and crashed asleep around 7 am. He was at an all-night party where there was a lot of drug use, and didn't feel out of place though most others were much less sober than he. This could be very good for things like necessary driving when overtired.

[snapper]

SWIM has also found this stuff underwhelming so far to the 25 mg mark. Virtually no euphoric or overtly stimulating effect, but SWIM was also being more productive and talkative. Feels somewhere in between what modafinil is supposed to feel like (ie-awake with no fireworks -not even a fizzle..) and maybe wellbutrin. It does have an effect and may be productivity-enhancing, but otherwise is nothing especially recreational.
Maybe SWIM will differ in opinion with a higher dose, but something tells SWIM that after reading initial testimonials SWIM will continue to be disappointed. Might be worth considering as a combination with another CNS stimulant, but then again this stuff is supposed to negate the effects of cocaine like naloxone with opiates, so maybe this will be a waste of good product...
Too bad this one's not panning out...

[nanobrain]

^no, that's the strange part, no neurotransmitter depletion or burnout was noted, just the oddest emotional misassociation, like getting pissed off that the sky is blue..or not the right shade of blue, totally irrelevant triggers.

for the rectally dosed rodents, what is the duration of the comeup?

[turkeyphant]

Could people summarise their experiences using this as a concentration/productivity enhancer with specific reference to their preferred dosage regimes?

[nanobrain]

yep. if you plan to drive in 6 hours time for about 2 hours.

[snapper]

So far SWIM's oral experiments are less than brilliant. SWIM finds the degree of stimulation minimal at doses up to 50 mg, and it feels very non-euphoric but edgy like ephedrine. SWIM has found 20mg good for energy, but still with a subtle malaise at the tail end of the experience. SWIM is still getting a feel for this one, but is beginning to think it's potential is not great. No real euphoria. SWIM still thinks MDPV is far superior amongst the unprohibited stimulants.

[snapper]

SWIM is also curious to hear more details. SWIM has only pushed this to about 50 mg so far and already did not like the effects orally. 20 mg seemed good for an energy lift, but it felt weird after that. SWIM plans other trials but is taking some time out to let the dopamine receptors upregulate. SWIM already has a few bad habits and does not want to make stimulants another one.
SWIM would love to hear about other's experiences. SWIM suspects the antagonism with this compound comes later than the binding. The initial receptor binding likely causes a rush, and the continued occupation causes it to be blocked. Rectal or other modes of administration bypassing liver with cause a more rapid saturation of receptors causing a rush. Given that the dopamine receptor and reuptake sites are similar, from the data and descriptions of activity so far, there is clearly some dopamine antagoism or partial-agonist activity at the binding site as well as the reuptake site. SWIM will attempt a lit search at some point. There must be more receptor studies on this compound since it was being researched as a drug, and it would make sense to have something that has antagonistic activity to give out as a harm reduction drug for coke addicts.
Anyone know why it was never marketed ? Were there health problems during trials or abuse potential ?

[Alfa]

For those who have not picked up the correlation:

Originally Posted by Nicaine

SWIM has been experimenting heavily with this chemical lately.

Lots of people will never appreciate pure dopamine reuptake inhibitors, or give them the respect they deserve, which is understandable -- ISE they are intrinsically unsatisfying at normal dosage and length/frequencies of use, so those who do like them typically fit a certain class of nutcase who will dose 5x the usual amounts for 96 hours straight and such... LOL. SWIM's current research involves 48 hours straight, followed by 5 hours sleep, followed by another 16 hours (so far). At least it isn't too strong an appetite suppressant, SWIM has been eating fairly normally.

Originally Posted by Nicaine

That said, there is potentially a big problem, particularly with higher and more frequent dosing: Addiction, compulsivity, fiending, inability to stop using, sleep deprivation, malnutrition and consequent deterioration of physical and mental health. The typical "rat presses lever until it dies of exhaustion" syndrome. So I guess you can say they aren't so benign after all...

ISE there's *some* appetite suppression, just nothing serious. The stuff murders sleep, at least for SWIM.

Originally Posted by Nicaine

SWIM has been offline for awhile, after ending up in hospital with an extreme case of chronic sleep deprivation that crept up so slowly he was almost unaware what was happening. Six solid nights of sleep and he's still not back to normal, but things are improving.

SWIM still finds it hard to believe how devastating the effects of sleep deprivation, once it gets past a certain point... he had no idea just being alive could hurt so f*cking bad. It dramatically affects every aspect of emotional and cognitive functioning, and there's a constant, physical malaise so intense it's like pain. SWIM had insomnia along with it, and he could neither fall sleep nor remain awake any more. It was the worst thing he had ever experienced.

Anyway, SWIM is glad to be back & hopes his story convinces someone to get help before things get so bad that one is disabled and unable to function. Stimulant use was a contributing factor to SWIM's situation, but a lot of other things also contributed.

Note that he took close to a gram of Dipenyl-2-Prrolidinyl-methanol in 5 days and quantities of the desoxypipradol analog had also been taken around that period.

So far I see plugging doses of 25 - 50 mg and oral doses of 10 - 75 mg being used. With the exception of the incoming reports of 60-200mg.

[Bio-Cellular Enigma]

It looks like "nicaine" might serve as a source of verifiable data, if he/she kept records and was willing to share. Yet more data indicating the deceptively non-benign nature of this substance. LD50 is clearly just a small part of the story with these stimulants.

[Bio-Cellular Enigma]

For my friend “BCE” a short experience report. Male, 5-11, 175, no stimulant tolerance. 5 or 10mg snorted switching off nostrils, producing an immediate but short lasting stimulation effect. Caused a frigid feeling in SWIM's nostrils which became a painful cold, freezing, burning sensation in the right nostril. Became extremely painful in right nostril within five minutes, water rinse helped somewhat. Felt like acid ate away the inside of SWIM's nose on the right, but feeling went away within an hour.

Shortly thereafter, 20mg diphenyl prolinol taken rectally (dissolved in ~3mg water) as {SWIM} was advised to try. Effects noted rapidly. Not a rush but came on very fast. Moderate stimulation with flood of symptoms that say dopamine, mebbe 85% central and 15% peripheral. Slight increase in heart rate with occasional mild arrythmia. Craving to begin re-dosing came with first dose and stuck around til the high left {Note -- subject did not re-dose}.

Stimulation became uncomfortable after ~10 minutes and 1mg Klonopin was taken which was noticeable within 35 minutes and quelled the discomfort. Moments of euphoria come & gone but the sensation just as often felt like drinking too much coffee. "Half fun, half feeling ill" That’s all SWIM has, promised to pass along one more {should it be tried again}.

* SWIM realized he didn't check total duration of effects... will edit later.
* Total intake was 20-30 mg, with extent of intranasal absorption unclear as it was not sustained for long.

[Bio-Cellular Enigma]

SWIM thinks he may actually be about to earn a little bit of fame (or notoriety, as the case may be) with researchers here.

He was visiting with his friend today, and as it was a quiet Sunday SWIM's friend (whose name is Dan BTW, fwiw) decided to research a bit of D2PM. SWIM suggested adding a bit of baking soda to the liquid it was dissolved in to aid rectal absorption. His friend is new to that method of admin and readily agreed. However, SWIM thinks he overdid the baking soda by quite a lot.

Five minutes later, Dan pointed out to SWIM that the D2PM solution had dramatically changed color and consistency (from yellowish and clear to opaque white and "grainy"). SWIM found this very interesting. He took the small beaker of D2PM and baking soda solution and heated it to boiling point (it actually boiled for a second or two). The result was a mostly clear fluid, with some quantity of mushy-looking white residue sticking to the inside of the beaker.

SWIM got an idea, and he suspects others will know where this idea came from. He collected the white "gunk" and dried it out with a cigarette lighter.

Smoking was attempted, and was at least partially successful. No 'taste' was evident that suggested caustic or overtly toxic products (e.g. 'plastic-y taste'), and the "cool/frigid" feeling produced by D2PM on soft tissues was evident in SWIM's throat when inhaling the smoke. Obviously, a significant amount of unchanged substance made it into the smoke. Note that there may in fact have been toxic breakdown products (taste doesn't mean too much) but SWIM did get two lungfuls of very light and dissipate smoke without suffering any ill effects.

SWIM smoked too little to have any effect (so did Dan), but he thought this experiment well worth posting about. He does not intend to continue this experiment himself, but his friend wants to try it again with a larger amount of D2PM and better controls in terms of determining proper ratio of water/baking soda/D2PM, using dh2o instead of tap water and -- finding out exactly what happens to D2PM when alkalized and exposed to heat.
BR>SWIM would be really curious to see if anyone else has success with this...

[sterling77]

Great that's really gonna help users wean off coke..just joking. Swim is immensely interested in your experiment.

Is your swiys friends going to apply the whole process involved in the coke --> crack conversion?

[Bio-Cellular Enigma]

Originally Posted by sterling100

Great that's really gonna help users wean off coke..just joking.

SWIM should add that he felt nothing from two (admittedly small) inhales, and that this substance is not highly potent in the first place. It shouldn'tbe like crack, more likely just much faster acting than other methods. There may be potential for a "rush," there may not.

The stuff SWIM ended up seemed to break down sanely when heated (unlike the parent compound), but there may still be unpleasant chemical by-products; this whole thing should be discussed further before people go running off to try it.

Swim is immensely interested in your experiment.

Some people do prefer smoking as a method of intake; SWIM is not really among them (any more), having decided to try and conserve what's left of his lungs.

Is your swiys friends going to apply the whole process involved in the coke -- crack conversion?

Probably not, as the reaction isn't identical; SWIM is not quite sure what's happening chemically when the baking soda is added and heat applied. Hewould appreciate input from someone who's familiar enough with this compound to figure it out.

[sterling77]

I guess you'd be looking for it to vaporize (akin to the other discussed substance) instead of breaking down. Swim isn't planning on researching any stimulants for a long while and this especially applies to smoking, but this is still very interesting. Some discussion on this would be nice- swiy says it reacted better when introduced to pyrolysis?

[Bio-Cellular Enigma]

It reacted dramatically better, or so SWIM is told (how the original reacts is hear-say to him, but he did see how the converted stuff reacts). Apparently the original substance catches fire immediately, emitting a thick, black smoke and burning fast (completely non-smokable). After the aforementioned processing, it does not catch fire and degrades MUCH more slowly (smoke color was white, SWIM seems to remember)... it may be vaporizing, or possibly a combination of breaking down and vaporizing.

A little bit further info: SWIM's friend tried it again, and it seems it's official; It IS smokable (i.e. has the expected effects when smoked, with no overt toxic effects). SWIM's friend did say something about their "lungs hurting" after smoking what amounted to a pretty small amount though...

[nanobrain]

Abstract
basification of D2PM was attempted approximately 2 weeks prior to BCE's info posted above.

Materials and Methods
to 500mg D2PM, 100ml hot (70C) H20 was added pourwise in a glass container. 500mg baking soda was then added in 1/4 increments and mixed well with a stainless steel spoon.

this resulted in the mixture becoming opaque and cloudy. left to settle for 10 minutes, two phases could be observed, a clear aqueous phase and suspended therein, white cloudy clumps. ontop, there was also a very slight amount of oily film, which could have been the result of contamination or a reaction byproduct.

the water and film was poured off, the cottage-cheese like remainder rinsed several times in warm H20 and dried.

the result was a mass of fine, voluminous white powder with organoleptic properties differing significantly from those of the starting material.

unlike D2PM's slighly minty odour, this material smells horrible - a mix of musty hampers, burnt plastic and old dill. it is much less dense, more voluminous and whiter.

Experimental Part
knowing nothing about the product obtained, an ageing but nontheless unwise rodent trained to differentiate several subclasses of DRI effectors was subjected to 3 serial inhalations of approximately 30mg of the material mixed evenly in a nonpsychoactive carrier matrix and pyrolised in a waterpipe.


Results and Discussion
the results were describred as being:

1. totally underwhelming and without any DA activity.
2. thoroughly disgusting tastewise, much worse than the smoke obtained from vaporising the D2PM
3. potentially toxic, since the rodent was seen coughing, cursing and complaining of lung pain for about an hour post admin.

Conclusion
smoking the basified product of D2PM and baking soda is not a viable, but potentiall toxic ROA.

the rest of the resultant product was then at-once added to the water flushing down the toilet with nil anti-coriolis effects observed. no further experiments will be attempted with this awful material.

Reputation Comments on this post:

	useful information
	Thanks for taking one for the team! (Do be careful though)

[Bio-Cellular Enigma]

Originally Posted by nanobrain

smoking the basified product of D2PM and baking soda is not a viable, but potentiall toxic ROA.

Very strange... did SWIY attempt duplicating SWIM's (or actually his friend's) procedure exactly? In other words, a very small amount of baking soda, and boiling specifically in the microwave. He doesn't know why this would make a difference, but it did -- the results were very different than SWIY's. SWIM has seen it for himself, and has no reason to lie.

[snapper]

SWINanobrain is a braver (or more foolish) entity than SWIM.
Thanks for the warning...

[nanobrain]

to be sure, the experiments were conducted roughly 2 weeks apriori BCE's. the experiments were not and will not be repeated, as the material was deemed thoroughly without merit.

[Rush]

Here is SWIM experience with D2PM:

at 35 mg, oral :
time +2h :after a slow onset a definite stimulation was noted.
time +3h uddenly a strong anxiety(can describe best that as 'panic'.) appeared. frightening!
time +3h&half :
physical effects: chest pain, back pain, diuretic effect(pissing a lot), no change pupils, rapid heart pulse, raise in body temperature,very dry mouth(disidratation),natural shaking in hands is killed, cordination of movements increased.
psychological effects: extreme concentration, very strong stimulation, anorexia(but no problems in forcing eating), no noticeable euphoria(instead SWIM was empty from emotions...can't even smile!), extreme insomnia, a lot of anxiety, amplification of pleasure, increased motivation, mild addiction potential.

time +5h.: anxiety seems to fade away(finally!)

time +7h:here is the crash! primary effects start wearing off: mouth returns wet, chest & heart pain fading away. stimulation keeps going on, but at the same time , there is an extremely tired & sleepy feeling. head is free of thoughts, cant think at anything!
also its impossible to sleep, but stimulation is in some ways still there. concentration & alertness still present, but sleepyness makes it useless
time +12h: finally some sleep!
time +18h: getting up, stimulation and concentration still there, with also tiredness, emptiness and anhedonia. that's annoying!
time +20h: finally those after effects got away! some natural happiness comes back!


COMMENTARY: maybe some lower doses should be explored, because at 35mg physical body load is greater than wanted psychological effects,and this is not useful for any purpose.
crash is addicting: in the crash phase there is a recurrent, compulsory thought of redosing, that goes on for 30-40 minutes.
however, its not that strong, at least for SWIM, that wisely, didn't redose
this chemical seems to be extremely potent in insomnia and anorexia, so it may be useful for those purposes

unwanted anxiety, some paranoia and bad feelings...some dangerous heart pains and unwanted body load...incapaciting anhedonia during comedown.... this stuff sucks, in swim's opinion!

Reputation Comments on this post:

	thanks for the trip report
	Thanks for the report.

[lulz]

Jesus DONT SNORT THIS STUFF.

My uncle Joe got some on Monday, and will edit this post with his report on it, but right now his left nostril feels like he snorted a line of salt. For the record, I can barely say the word "source" without breaking rules, but the one Joe got this from has a pretty much perfect reputation.

Stupid mistakes like this teach uncle Joe at least. In future he would do something like search the thread for "snort" or "snorting" first. Jim Beam probably let him down tonight and boosted his stoopid powers. Jim! You've always been so good to me... I'll drink you to teach you a lesson, we'll see who has the last laugh.

[Alfa]

Dosage: 60 mg diphenylprolinol
Route: Orally
Duration: 5 hours

Weight: 55kg
Sex::Male
Physical state: healthy
Mental state: healthy/tired
Setting: bar
Food consumed: little
Other drugs consumed: none

Timeline
Ingestion: 0.00 AM
Onset: 1.00
Peak: 2.00 - 2.30
Decrease: 4.00
Baseline: slept at 5.00

Effects & side effects
Initial effects: warm feeling and tingling in my head
Physical effects: warm feeling in my body, shaking muscles, yawning
Mental effects: euphoric, but lacking the loving feeling I enjoy with XTC/methylone, it lacked something, inability to concentrate.
Visual effects: clearer and warmer and now and then fuzzy
Physical discomforts: painful and restless bowels, nausea.
Could you sleep: yes
Could you eat: no
After effects: euphoric next day, but shaky

Conclusion
Rating: 3/5 ok. It has advantages and disadvantages.
Would you try again: in another setting to see how that is.

* This experience report was part of a smartshop study, that resulted in aborting the study. After the study the compound was used by another party pill distributor and ended up in London underground's Neuroblast

[Alfa]

Dosage: 60 mg diphenylprolinol
Route: Orally
Duration: 8 hours

Weight: 80kg
Sex: Female
Physical state: Healthy
Mental state: Healthy/ good
Setting: At home
Food consumed: normal dinner
Other drugs consumed: beer + wine

Timeline
Ingestion: 20.00
Onset: 22.00
Peak: 01.00 - 04.00
Decrease: 04.00
Baseline: 06.00

Effects & side effects
Initial effects: warm glow through body
Physical effects: energy, tingling, yaw tension
Mental effects: clearness, openness, connecting, talkative, many thoughts,
Visual effects: needed glasses
Physical discomforts: rapid heart beat
Could you sleep: no
Could you eat: no
After effects: fuzzy

Conclusion
Rating: 3/5 good. Effect took long to establish. feels good
Would you try again: yes, for at home (sex)

* This experience report was part of a smartshop study, that resulted in aborting the study. The distributor did not use the compound. After the study the compound was used by another party pill distributor and ended up in London Underground's Neuroblast

[Alfa]

As mentioned above, I recently got into possession of these diphenylprolinol experience reports that where part of a study done by an unnamed Dutch smartshop. There where many more reports like this, but they were pretty consistent and frequently showed signs of heart problems, craving, inability to sleep for long periods(even for days).
The diphenylprolinol study was aborted because of health concerns. The The distributor did not use the compound. After their decline the diphenylprolinol was used by another party pill distributor and diphenylprolinol ended up in London Underground's Neuroblast.