Pharmacology - Benzo Categories

[Laudaphun]

SWIM has recently ran across some categories of benzodiazepines. Triazolobenzodiazepines and Nitrobenzodiazepines. SWIM has been searching to uncover which benzos fall into which categories and which other categories there are however, other than Wikipedia, where only 5 or so compounds are associated with these 2 categories, SWIM has had little luck finding out more about these labelings. SWIM is sure that the labeling is result of the chemical structure, but his chemistry knowledge is not good enough to explore this further by examining the structures.

[Psych0naut]

The triazolo benzodiazepines all end on -lam, alprazolam, midazolam, estazolam, triazolam. The 1,4 benzodiazepines are the major group, all ending on -pam, like diazepam etc. And than you have the smaller sub-categories like the chlorinated, and nitrated benzodiazepines, but they aren't really categories for as far as I know. There is a third category as well, the 1,5 benzodiazepines which end on -zam, clobazam, arfendazam, lofendazam.

Reputation Comments on this post:

	very informative
	some new 'should already know' -info
	Good info didnt know that

[Wyborowa]

Can anyone tell us their different effects?

[Laudaphun]

Cool thanks, there are so many different benzos and derivatives out there... being able to sort them will be very convenient.

[Matt The Funk]

SWIM didn't know this. Interesting stuff.

[Orchid_Suspiria]

Its mind boggling just how many different benzos are created,some swim has never even heard of and is sure might not even be scheduled in the United States.

[Psych0naut]

Originally Posted by Wyborowa

Can anyone tell us their different effects?

For as far as I know their different effects can't be attributed to their different classes, it's different for each individual benzo. The only thing I can think of is that the triazolo benzodiazepines are the most potent ones, Halcion(triazolam), Dormicum(midazolam), Xanax(alprazolam) and Lendormin(brotizolam) all belong to this group, and are the most potent benzo's around.

Posession might still be prosecuted under analogue acts in the US, and the UK, but in countries who don't have analogue acts, most of those unknown benzodiazepines are unscheduled, for example in the Netherlands. There might be possibilities there as a research chem.

[tranquillike]

so the prototype for all benzos would be 1,4 benzodiazepines which would have been originally based on chlordiazepoxide?

Reputation Comments on this post:

wow cool, something that i'd overlooked. Thanks

[Jatelka]

Chlordiazepoxide was indeed the prototype.

See here... http://www.drugs-forum.com/forum/sho...lordiazepoxide