Drug info - SSRI prevent amphetamine euphoria?

[Daytona71]

SWIM asks this after reading the mission statement on SSRI's and SWIM had been taking Cymbalta dna Dextroamphetamine but the old euphoria of the D-amp was not there so the Cymbalta was stopped a few days ago. My understanding was that anti depressants helped the serotonin be transmitted better between receptors or whatever causes D-amps to have thaT EUPHORIC EFFECT. THX for additional info.

[toe]

SWIM would toss out a guess that the greater dampening effect on amphetamine euphoria from duloxetine is caused by its SNRI actions, rather than its SSRI action. AFASK, D-Amphetamine effects are a result of norepinephrine and dopamine activity. "A few days" is nowhere near long enough for the receptors to reset themselves to baseline.

[Codehead]

SSRI + amphetamine works normally. Same euphoria like always.

[IntrepidTraveler]

Through personal experience, SWIM doesn't think an SSRI should alter the effects of amphetamine. SWIM takes 20 mgs Escitalopram (Lexapro) daily and adderall seems to have all of the same effects--euphoric and otherwise.

[Daytona71]

Phamacist confirmed the combo should not present a problem and (that Serotonin Syndrome is more likely with two SSRI's being prescribed together.) SWIM was told by person taking care of SWIM's Morphine pump that age was likely the issue, SWIM's, not the Dextro's! The D-amps still keep SWIM awake driving and duing other tasks where falling asleep could be dangerous to others or to SWIM. THX

[Jatelka]

^^^ I'd get yourself a new pharmacist Daytona71.

SSRI's and Amphetamine are judged to have an "intermediate" risk of serotonin-syndrome when combined

(struggling to find source for this statement at present, but definitely remember reading a paper!)

[Digemlo]

Just remember: even though antidepressants are called S_RIs (with the _ reperesenting the "main" neurotransmitter affected), that doesn't mean that they only affect that type of receptor. So yes, and SSRI could prevent amphetamine euphoria by side-reaction.

[Codehead]

Originally Posted by Digemlo

Just remember: even though antidepressants are called S_RIs (with the _ reperesenting the "main" neurotransmitter affected), that doesn't mean that they only affect that type of receptor. So yes, and SSRI could prevent amphetamine euphoria by side-reaction.

SWIM has personal exprience, he has used citalopram for 6 months and amphetamines still gives just the same good effects as they did before using SSRI. So no, they don't prevent.

[IntrepidTraveler]

Originally Posted by Jatelka

^^^ I'd get yourself a new pharmacist Daytona71.

SSRI's and Amphetamine are judged to have an "intermediate" risk of serotonin-syndrome when combined

(struggling to find source for this statement at present, but definitely remember reading a paper!)

It is my understanding that the risks for serotonin-syndrome with this combination is actually quite rare, rather than "intermediate." In fact--while certainly not a definitive source--the adderall Wikipedia page seems to confirm this: "SSRIs (selective serotonin reuptake inhibitors, e.g., Fluoxetine, Citalopram, Paroxetine, etc.) — While rare, the possibility for serotonin syndrome exists with this combination. Use only when it is directed. "

In SWIM's fairly extensive experience with both classes of drugs--and this includes his personal diagnosis/treatment received from numerous unique, recommended doctors--the combination actually seems to be perscribed quite often.

[Daytona71]

Likely as the nurse who attends to SWIM's Morphine pump, age and hormonal changes. There have been 3 who are half a century or older who have had no euphoric effect. More wake and a bit anxious but not euphoric. As was stated on this or another D-amp forum a Black Beauty back in the day, 20mg., rocked SWIM and now double that or maybe a bit more does not come close. 20mgs. and SWIM can go to sleep. SWIM is taking many downer types of medication due to an injury so that could be part of it also. Perhaps cutting back on some for a bit might be a thing to try. Thought SWIY saw a thread on methamphetamine systheses being fairly easy starting with d-amps but have not found it, anyone?

[KillroyMindless]

ok d amp works on dopamin and ssri works on seratonin but there are some like bupropion that will hit dopamin too bupropion and d-amp are suposed to boost the effects of each other. i dont know about cymbalta though

[upperdecker]

When SWIM was on SSRI's he noticed a bunch of drugs didn't work. First, shrooms didn't work at all (tried them like 3 times with no luck), Oxycontin was hardly noticeable (you could really feel the Oxy trying to work but you can tell somethings holding its effects back). Also E didn't work either. Eventually SWIM came off of SSRI's and eventually all of the drugs that didn't work started to work.

[staples]

Originally Posted by upperdecker

When SWIM was on SSRI's he noticed a bunch of drugs didn't work. First, shrooms didn't work at all (tried them like 3 times with no luck), Oxycontin was hardly noticeable (you could really feel the Oxy trying to work but you can tell somethings holding its effects back). Also E didn't work either. Eventually SWIM came off of SSRI's and eventually all of the drugs that didn't work started to work.

This doesn't seem right, could you ask SWIY which SSRI he was taking when he noticed that other drugs didn't affect him?

[upperdecker]

Originally Posted by staples

This doesn't seem right, could you ask SWIY which SSRI he was taking when he noticed that other drugs didn't affect him?

He was taking Paxil. Not sure of the dosage when he tried the other drugs though. It didn't seem right to SWIM either. SWIM remembers eating an 8th of shrooms and his friends didn't understand why SWIM didn't trip at all. Nothing. Same exact thing for E and Oxycontin. For oxy, he could actually feel the euphoria a tiny bit but thats it. And as SWIM said, after he got off Paxil, all of the mentioned drugs worked as they should.

[upperdecker]

So the point SWIM was trying to make ^ is that he wouldn't be suprised if SSRI's blocked the effects of amphetamines.

[KillroyMindless]

ya usually ssris dont effect endorphin production but i quess you can never know any more

[IntrepidTraveler]

There are alot of threads on this already. SSRI medication often interferes with psychedelic substances and also seems to lessen the effects of MDMA. UTFSE

[staples]

Originally Posted by IntrepidTraveler

There are alot of threads on this already. SSRI medication often interferes with psychedelic substances and also seems to lessen the effects of MDMA. UTFSE

Hi

I am aware of this and even referenced it in a somewhat recent post around here. Upperdecker mentions that Paxil blocked the effects of oxycodone, however, which shouldn't be affected by an SSRI -- in rare cases serotonin syndrome is known to occur (less-so with oxycodone, I believe), but other than that, people taking SSRIs are administered opiates just as those not taking SSRIs are; it should work just fine.

[IntrepidTraveler]

Originally Posted by staples

Hi

I am aware of this and even referenced it in a somewhat recent post around here. Upperdecker mentions that Paxil blocked the effects of oxycodone, however, which shouldn't be affected by an SSRI -- in rare cases serotonin syndrome is known to occur (less-so with oxycodone, I believe), but other than that, people taking SSRIs are administered opiates just as those not taking SSRIs are; it should work just fine.

True. SSRIs should not lessen the effects of opiates/oids. In fact, SWIM has never seen any convincing evidence that SSRIs will negate (or partially negate) the psychoactive effects of any substances other than MDMA and psychs.

[racemethorphan]

Originally Posted by IntrepidTraveler

True. SSRIs should not lessen the effects of opiates/oids. In fact, SWIM has never seen any convincing evidence that SSRIs will negate (or partially negate) the psychoactive effects of any substances other than MDMA and psychs.

Citalopram certainly knocks out codeine, the mechanism being CYP2D6 inhibition (the pathway which codeine metabolism is highly dependent upon).

SWIM knows because SWIM tried... FAIL.

[nAzTNM]

Originally Posted by racemethorphan

Citalopram certainly knocks out codeine, the mechanism being CYP2D6 inhibition (the pathway which codeine metabolism is highly dependent upon).

SWIM knows because SWIM tried... FAIL.

SWIM wouldn't say that. SWIM finds it quite a decent buzz. It definately does something.

SWIM has been on the AD's for 7 months though.

[upperdecker]

SWIM mistakingly said Paxil and meant Wellbutrin. He was on Paxil for a while which blocked shrooms and E but when he was on Wellbutrin he could hardly feel anything from Oxy. SWIM apolagizes for mixing up the meds (he's been on alot of them and sometimes its hard for him to remember when he was on what).

[staples]

Originally Posted by upperdecker

SWIM mistakingly said Paxil and meant Wellbutrin. He was on Paxil for a while which blocked shrooms and E but when he was on Wellbutrin he could hardly feel anything from Oxy. SWIM apolagizes for mixing up the meds (he's been on alot of them and sometimes its hard for him to remember when he was on what).

Bupropion (wellbutrin) is not an SSRI, and (for anyone else reading) mixing it with oxycodone shouldn't do nothing, but it might cause a seizure...

[upperdecker]

Originally Posted by staples

Bupropion (wellbutrin) is not an SSRI, and (for anyone else reading) mixing it with oxycodone shouldn't do nothing, but it might cause a seizure...

SWIM is aware Wellbutrin isn't a SSRI. He was just letting you know that he mistakingly said Paxil instead.

[lloydsLSD]

My friend has been on 10mg Cipralex daily for a few years and, while he has always told me that he shouldn't take amphetamine because of the risk of serotonin syndrome, he does use whizz a lot. He says that the buzz is enhanced due to his medication very noticeably but he would never encourage anyone else to put their health at risk. He just speaks from his own actual experience of this you see.

lloydsLSD added 17 Minutes and 34 Seconds later...

Sorry. I meant that my friend said that the "high" was better due to the combination, but I forgot to add that on a couple of occasions my friend would become tight chested, fell unwell, very anxious and scared - to the point of him ringing an ambulance.

So it's not worth the risk IMO and my friend is a twat. Other SSRI's might have an even worse effect.