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DXM Dextromethorphan

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  #1  
Old 02-10-2007, 21:53
faren1 faren1 is offline
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DXM not working anymore

SWIM has tried DXM about 3 or 4 times with amazing results about 2 of them. SWIM is wondering why at the same dosage, about 360mg, sometimes SWIM has a great experience and othertimes barely feels anything.
  #2  
Old 02-10-2007, 22:08
Graduisic Graduisic is offline
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Re: DXM not working anymore

tolerance may be an issue. in the future, swiy should be more specific about dosages, such as, the amount of time spent between doses
  #3  
Old 02-10-2007, 23:15
Paracelsus Paracelsus is offline
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Re: DXM not working anymore

Another important factor (if chronic use is not the case) is stomach contents. If taken on an empty stomach (4-5 hours after last meal), DXM is much more potent.

From my vampire's one-year-old stories I know that the same dose that would be very potent on an empty stomach can have a delayed, weak and extended effect when consumed after a meal.
  #4  
Old 03-10-2007, 20:31
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Re: DXM not working anymore

What is a safe dosage of DXM? I've got that cough medicine that contains only DXM but I don't know how much to take.

Thank you!!
  #5  
Old 04-10-2007, 11:14
Paracelsus Paracelsus is offline
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Re: DXM not working anymore

The safe dosage is up to 30 mg. Recreational doses start at 1.5 mg/kg (105 mg for a 70kg person), which would most likely be safe for a first-time user. But that first time user certainly isn't YOU.
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Old 04-10-2007, 22:17
darkglobe darkglobe is offline
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Re: DXM not working anymore

SWIM's first use was (don't laugh!) 80mg of DXM.

Taken on an empty stomach, In syrup form.

It produced a somewhat strange "floaty" feeling, and made speaking slightly awkward. Also gave SWIM the "jumpy" feeling that around 50+mg of Diphenhydramine gives.

Not unpleasant, apparently. I'm told it was actually very enjoyable.

Subsequent use (literally the next use and all others) required sharply increasing dosaging in order to achieve the same effects.

SWIM (long-term user, but not regular at all) says that is personal dosages are as follows:
1st plateau - almost unattainable these days. Either gets negligible effect or ends up with double vision.
2nd plateau - around 400mg
3rd plateau - 800mg
4th plateau - SWIM has never knowingly reached this plateau, neither has he ever taken more than 800mg.

Incidentally, SWIM weighs 76.7Kg and is male, in good health and aged 19 years.
  #7  
Old 10-10-2007, 18:28
lsh lsh is offline
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Re: DXM not working anymore

Quote:
Originally Posted by Paracelsus View Post
The safe dosage is up to 30 mg. Recreational doses start at 1.5 mg/kg (105 mg for a 70kg person), which would most likely be safe for a first-time user. But that first time user certainly isn't YOU.
Thanks for the advice. And SWIM never took it in the end, in case it reacted with the SSRI's he's taking (escitalopram.) He decided to read up on the subject as it was completely new to him, he'd never even heard about it from friends etc...

It seemed to me though that the information regarding SSRI's and DXM interaction is confusing - I'd read 1 thread and think "no way I'd try it", and then another thread seems to describe the combination as beneficial and better.

Anyway, I'm going to read some more on the subject as it's interesting to me.
  #8  
Old 10-10-2007, 19:26
darkglobe darkglobe is offline
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Re: DXM not working anymore

Read away

Just make sure SWIY doesn't take anything that could react nastily with those SSRI's.
  #9  
Old 10-10-2007, 21:33
FooDawg FooDawg is offline
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Re: DXM not working anymore

Isn't DXM an NMDA antagonist? Does it even touch serotonin? SWIM hasn't seen anything about DXM and SSRI interactions in the past, but then again he has never looked for it. Good to see that SWIY is being cautious and safe though. Anyone know anyone more knowledgeable on the exact effects DXM has on the brain? Maybe an extraction would be best for someone on SSRI's since SWIM is almost positive (just don't quote him, lol) DXM is just a straight NMDA antagonist. Maybe there is more to it?
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Old 10-10-2007, 22:06
FooDawg FooDawg is offline
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Re: DXM not working anymore

SWIM is retarded, he did a little bit of quick research and guess DXM does block serotonin uptake. So definitely good thing SWIY did some research and be careful above all else. SWIY might still be able to experiment, but if SWIY does, make sure the remain as cautious as they have been. SWIM is sorry for the misinformation, wishes he could edit his posts.
  #11  
Old 10-10-2007, 22:07
FooDawg FooDawg is offline
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Re: DXM not working anymore

http://www.uspharmacist.com/oldforma...at/acf2fa6.htm
-and-

Dextromethorphan should not be taken with any of the following:"DXM taken with any of these can cause Serotonin syndrome, a potentially life-threatening adverse drug reaction that results from intentional self-poisoning, therapeutic drug use, or inadvertent interactions between drugs which cause an excess of serotonergic activity at central nervous system (CNS) and peripheral serotonin receptors."

-Wikipedia page-

Post Quality Evaluations:
good post
  #12  
Old 10-10-2007, 22:07
darkglobe darkglobe is offline
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Re: DXM not working anymore

I'm not au fait with Pharmacology.... but....

http://www.erowid.org/chemicals/dxm/...m.shtml#toc.10

Should give ya what ya need to figure it out yourself.

As far as I'm aware, Serotonin Syndrome can occur with chronic DXM abuse. I think.

EDIT: SWIM will be able to edit posts soon, just continue to post well and you'll become a silver member
  #13  
Old 10-10-2007, 22:11
Paracelsus Paracelsus is offline
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Re: DXM not working anymore

Actually, DXM is a very low affinity NMDA antagonist. DXM acts mainly Sigma and PCP2 receptors. DXM is also a serotonin reuptake inhibitor and a serotonin receptor agonist.

There are some reports on this forum about certain SSRIs interacting nicely with DXM, but there are also reports of serotonin syndrome followed by this combination. The key is keeping track of the doses. If SWIlsh decides to try DXM, the doses should be much lower and raised carefully. Starting at around 80-100 mg and raising the dose in steps of aroun 50 mg would be fairly safe in that situation. Keep in mind that escitalopram also potentiates DXM by inhibiting CYP2D6.
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Old 11-10-2007, 01:17
FooDawg FooDawg is offline
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Re: DXM not working anymore

Quote:
Originally Posted by Paracelsus View Post
Actually, DXM is a very low affinity NMDA antagonist. DXM acts mainly Sigma and PCP2 receptors. DXM is also a serotonin reuptake inhibitor and a serotonin receptor agonist.

There are some reports on this forum about certain SSRIs interacting nicely with DXM, but there are also reports of serotonin syndrome followed by this combination. The key is keeping track of the doses. If SWIlsh decides to try DXM, the doses should be much lower and raised carefully. Starting at around 80-100 mg and raising the dose in steps of aroun 50 mg would be fairly safe in that situation. Keep in mind that escitalopram also potentiates DXM by inhibiting CYP2D6.
SWIM was going on the thought that it reacted quite a bit with the NMDA receptors. Here is why:

http://www.erowid.org/chemicals/dxm/...html#toc.9.2.4

SWIM would like to take the time to go through the articles he/she cited at some point once SWIM's own research writing slows down a bit.
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Old 11-10-2007, 03:43
Paracelsus Paracelsus is offline
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Re: DXM not working anymore

I forgot to mention that in the post above. DXM is a very weak NMDA antagonist, but dextrorphan is a much more potent one. Dextrorphan is also believed to be responsible for the pleasant effects of DXM. You can find a thread called 'Psychotropic effects of dextromethorphan are affected by CYP2D6 polymorphism: a pilot study' or similar in the DXM forum.

Since this thread has changed topics twice, it is now closed. Discussion can go on in more suited threads.
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