Acetaminophen: The Big Bad Wolf. Large Single Doses

[pixplzthx]

Well, I was doing homework on how badly a single large amount of acetaminophen would injure your liver.
And this is what I found.

It's a 2003 study on Acetaminophen levels 4 and 7 hours after 2000 and 3000 mg single doses in healthy adults (meaning no alcohol, I'm sure)

Originally Posted by Conclusion

Dosing by weight (i.e., mg/kg) appears to provide a more predictable dose-response relationship. Optimal adult dosing appears to be somewhere in the 20 to 30 mg/kg range based on the premise that the 4 hour level is a trough level that should be in the low therapeutic range.

So for all you responsible acetaminophen ingest-ers. Be smart but safe and base it on body weight.

Also, this doesn't seem to change the daily limit (no more than 4k of acetaminophen.

Needless to say, CWE is the optimal solution.

Reputation Comments on this post:

	helpful info
	Very useful info
	thanks for the info on this

[Tortoise]

Very interesting info. Thanks for bringing that to our attention!