Effects - Dizocilpine (MK-801) vs PCP

[papaown]

SWIM has heard many stories of people getting "enhanced strength and numbness" while using PCP. But he is wondering if Dizocilpine will bring about the same enhanced strength and numbness of pain as PCP does? SWIM has been told that people on PCP can fight amazing, but Dizocilpine will do about the same thing. Is SWIM incorrect?

[Nagognog2]

People on PCP also are known to pull out their own eyeballs and bite off their fingers. So I hope not.

[Paracelsus]

Dizocilpine is a chemical that can not be found anywhere else than chemical suppliers and research labs. I doubt many people have ever used it as a recreational drug. From these people, I doubt many have also used PCP. I also doubt that those people - if they existed - would read this forum. So most likely - no one.

[bravedog]

"Forensic Sci Int. 2003 Apr 23;133 (1-2):113-7 12742697
A multiple drug fatality involving MK-801 (dizocilpine), a mimic of phencyclidine.
Office of the Chief Medical Examiner of Harris County, Joseph A. Jachimczyk Forensic Center, 1885 Old Spanish Trail, Houston, TX 77054, USA.
MK-801 (dizocilpine) is a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) family of glutamate receptors in the central nervous system. It is an anticonvulsant and also shares several pharmacological properties with phencyclidine and ketamine. It is not observed routinely as a substance of abuse. The deceased, a 45-year-old white male, obtained MK-801 surreptitiously in an attempt to treat a self-diagnosed depression. He was discovered the next morning, unresponsive on the bathroom floor. An empty bottle, labeled to contain 25mg of MK-801, was found near the body.The autopsy was performed at the Joseph A Jachimczyk Forensic Center, Houston, TX. Body weight at autopsy was 88kg. Lungs were edematous and congested (right: 775g; left 700g). The heart had proportionate chambers and was otherwise unremarkable. The kidneys (right: 220g; left 225g) were smooth surfaced. The brain (1550g) was congested and without trauma. Microscopic evaluation of the heart, kidneys and lungs showed normal histology and confirmed pulmonary congestion and edema. Samples of heart blood, liver, bile, vitreous humor, stomach contents and urine were collected at autopsy. There were 550ml of stomach contents.Drugs in blood were screened by EMIT II Plus immunoassay procedures and by gas chromatography/mass spectrometry (GC/MS) of an organic solvent extract of basified blood. Alcohol was determined by gas chromatography with headspace injection. MK-801, benzodiazepines and alcohol were detected in blood.Amounts of MK-801 present in blood, bile, liver, vitreous humor and urine were 0.15, 0.29, 0.92, less than 0.1 and 0.36 mg/l (kg), respectively.The cause of death was benzodiazepine, dizocilpine and ethanol toxicity and the manner accidental. "

[tantric]

SWIM has used MK-801 (the report is on Erowid). You would most likely not remember the experience. Zombification. I suspect that PCP-like freak outs are possible, but for SWIM, SWIM wasn't coherent enough to be dangerous. More stumbling and blathering than rioting and destroying.