Anal use - Plugging / Rectal Tramadol?

[Cuberun]

Hi, was wondering if it's possible to plug tramadol to overcome naseua.
SWIM has some Ultram capsules 50mg each. No syringe unfortunately but has read about experiences of plugging other things in capsules.

SWIM can ingest 350mg of tramadol no problem in a day but after a while he starts feeling a bit queasy even though padded with or without food.

Yes, tramadol doesn't work for some but it works very well for SWIM, so no discussion about this please

Anyone have any knowledge on this?

Thanks

Reputation Comments on this post:

Thanks for starting this thread, just what Swim needed!

[trptamene]

I really can't say either way whether IB (intrabumum) will work, but have read that it if will work orally it will work rectally as well.

tramadol works we.l for swim too, but he lost his prescription for it. He took ultram nearly daily at the around swiys dose (250-400mg daily) for about a year. He sometimes felt the queasyness swiy talked about but mostly he experienced heartburn/acidic stomach problems after about 10 months of this, he hoped this would stop after he stopped taking it but 4 months later he still has these problems.

Daily this probably would not be a good idea, but if one is asking just for recreational value that does not occur often then it would be a good idea if this did work and there were no ill side-effects.

I am curious if anyone has any experience also.

[sarbanes]

Inferior method as it bypasses desirable 1st pass hepatic metabolism, and is rather irritating to perianal area at theraputic doses. But maybe will avoid the neausea?

Reputation Comments on this post:

Answered question

[Cuberun]

Thanks for the replies. Yes, SWIM doesn't get any naseua now once he's used to it. That also means it's time to stop though unfortunately

For next time it seems plugging isn't an option though.

[Mish]

SWIM was just wondering if plugging Tramadol actually will increase it's effect (i.e. require a lesser dose to achieve effects of a higher oral dose)

SWIM never gets nausea on Tramadol, but the oral come up seems to take a long time and SWIM finds himself going through a fair amount of Tramadol simply because the effects aren't quite strong enough. Would plugging help with reduction of dose to reach desired effects, or is the bioavailability high enough orally that it won't make any difference...?

[jayjohnson81]

Don't worry, you should still practice plugging with water or your favorite beer (just a couple plugs - you'll get ass-drunk real fast) so your ready for when you need to plug something for real.

(Sorry... I'm wasted.. )

[Intoxicating Dreams]

I am new here and finding the information fasinating and of superior quality (well the beer plug post above made me laugh pretty hard, even though I have done the wine enema thing once). Anyway, what is Tramadol? SWIM used to snort adderall, and other stimulants like it, but can no longer access it and it made her art much more enjoyable. Would tramadol or Ultrim make a good substutite. Do they require perscriptions? Thank you for any suggestions.

[trptamene]

UTFSE(use the forum search engine)

in general do not post questions that have been answered anywhere else on this site and do not add any information that is already on this site; this is good for keeping down all the noise and I think it may also keep the monthly costs down(maybe a mod can clarify this?)

from erowid

Tramadol is a quasi-narcotic analgesic used in the treatment of moderate to severe pain. It is a synthetic analog of codeine, but has a low binding affinity to the mu-opioid receptors. It has been prescribed off-label for the treatment of diabetic neuropathy and restless leg syndrome.

it is Rx in the US

[fiveleggedrat]

Swim has a good amount of tramadol. Problem is, for some unknown reason, it just flat-out stopped producing euphoria. Sedation is still there in bucketloads, but the euphoria is gone. Before anyone asks, there is ZERO physical tolerance. Only thing Swim is tolerant to regularly is marijuana. Opioids are consumed every few weeks. Swim has even taken several month breaks and came back to tram with the same issue.

Swim's real question is this: Even though rectal tramadol sounds like it would fail due to lack of 1st pass hepatic metabolism, is there possibility it will create euphoria? Swim used to believe that metabolite M1 caused most euphoria. Swim has tried every single potentiating combo he could thing of, most of them only increasing sedation and nothing else.

Could tramadol rectal act differently than oral? Perhaps Swim's body has developed some sort of "anti-tramadol" response? Could rectal be a way to pass it? And why could it have stopped being euphoric? Did Swim's brain just adapt to the tramadol and now prevents it from being euphoric?

Regardless of questions, Swim thinks he will attempt rectal tramadol soon. An experience report will follow.

[soma]

Erm, isn't the M1 metabolite responsible for most of the effects of Tramadol (being that it has roughly 1000x the affinity for the Mu opiate receptor). In theory, that would mean that by injesting it anally, you would bypass the 1st pass metabolism and therefore not create any of the M1 metabolite, thus killing any opiate effect of tramadol.

Reputation Comments on this post:

thanks for making me not post!

[StopDropNRoll]

Did you take any medicines that act on the CYP2D6 enzyme? These inhibitors include SSRIs, some antihistamines, some antipsychotics, cimetidine and some other mainstream medicines. If so, what is happening is the Tramadol is not being converted to M1, which is the metabolite that produces the euphoria. M1 metabolite binds to opiate receptors 100x greater than tramadol.

If you are looking for the euphoria side effect, the CYP2D6 inhibitors need to be out of your system. *However some of the medicines should not be discontinued abruptly, such as Prozac, etc.*

Also--if you are indeed on any of the inhibitors, the risk of serotonin syndrome increases with this medicine.

I take Prozac, and I combined it with 400mg Tramadol one time. I was having tics on the right side of my face, vocal tics where it appeared that I had a speech impediment; also I suffered chest pains. I felt like I was on the verge of a seizure or heart attack. It was not pleasant at all.

I also believe that smoking cigarettes activates some of the side effects such as nausea and the muscle spasms, as nicotine temporarily increases dopamine and acetylcholine which are both neurotransmitters involved in the muscular system.

Hope this helps. See a list of "CYP2D6 inhibitors" for more information.

*There is well documented case histories of tonic-clonic seizures occuring in people who abuse Tramadol. Please be very cautious as always, and understand the risks someone takes when they are choosing to use high doses of this medicine.*

[LostAllFeeling]

tramadol is not a drug that has any real useful properties unless metabolized through the stomache and etc. some people report effects from snorting, but they are always extremely minute and commonly it is regarded as a waste unless taken just as a pill. in theory one could parachute tramadol or crush it up and injest said powder. it would probably hit harder and not last as long which for tramadol would be a huge plus. SWIM apologizes that he cannot offer any advice to get over the nausea. Tramadol is a very nauseating drug if used in high enough dosages to produce a recreational effect. SWIM would move on to something more tolerable on the stomache, or something that actually could be snorted or plugged. best of luck