Oral use - oral capsule ingestion of cocaine

[RoboCop]

Alright I searched this cocain forum for info on ingesting coke in a capsule and no one has ever said anything about taking a capsule full of coke oraly, im just wondering because i got some now and am wondering how different the high would be going straight to your stomach and digestive system? Wouldnt it feel alot different than snorting?

[psyko_tripper]

I don't think that coke will be absorbed by the stomach. So you would just be wasting your coke.


But I'm not a pro on this!


any other comments....

[OneDiaDem]

Ive heard of it being capsuled for moving. I do not believe it was meant to be taken orally. The capsules are used in place of vials or wraps.

[32785]

Do NOT take orally, it will do nothing, but depending on the dose..........it may kill you! happy trails!

[apoch22]

i would assume the result would be some high some wast and a slightly different buzz. i've eaten coke, and i'm sure a lot of it was absorbed in the mouth and esophogus, but once in the stomach it is probably useless.

[Kemikaru_Tenshu]

http://cocaine.org/pharmacotherapy/


An excerpt:


"RESULTS: Oral cocaine produced no subjective effects or signs of toxicity but produced dose-related physiological effects. Significant interactions between oral and i.v. cocaine were observed; cocaine (100 mg, p.o.) significantly decreased responses to the 25-mg but not the 50-mg dose of i.v. cocaine for heart rate, mydriasis, and some subjective measures. There was no evidence of significant additive effects, although heart rate responses to i.v. cocaine were exaggerated during the final wash-out period."





~KT

[Kemikaru_Tenshu]

Here is another one for the more scientifically inclined:


http://jpet.aspetjournals.org/cgi/reprint/295/2/634.pdf


This article also contrasts the half life of cocaine and its metabolites, which will be interesting and usefulto a lot of you.





~KT

[Fantasian]

so in simple terms does this mean "Dont eat/bomb coke".

SWIF was looking for a longer duration of effects than insufflation of cocaine.

[Danc9552003]

Yeah, for sure don't eat it, it's such a waste. When SWIM gets a big drip it kinda sucks because a lot just went into his stomache where nothing happens at all to it.

[Fantasian]

SWIF heard that it is absorbed at about 20% in the stomach but atually in the small intestine is readily absorbed at quite a high level?

Is this not true?

[MadShroomer]

I've seen a show on TV where a guy was in peru and visited a dr who it was explained was a "shaman" or something (although he was in a Dr. Office with professional attire). Anyway, he ate ~ 3g of cocain altogether in 1g "sugar cube" looking things so he could diagnose the guy using some form of sense feeling the guy with his hands it was wierd. But although obsorption in the stomach/gi track sucks it apparently is possible as this dude looked all HOT and SWEATY at the end of the examination (crunk'd as a mug)

[pankreeas]

sorry to pump more helium into this ancient post again.. but swim just had to add that last night's experience was mimiced tonight and to keep things short we'll say with virtually identical results. Swim can't wait till next weekend to wash rinse repeat.

[Jatelka]

If anySWIY can access the full article linked to in pankreeas' post it would be a very useful addition to the archive.

[Bajeda]

http://www.drugs-forum.com/forum/loc...=1129&catid=25

Abstract: Administered cocaine (2.0 mg/kg) orally and intranasally to 4 25-32 yr old males in 2 experiments. Cocaine given orally was found to be at least as effective as the same dose given intranasally. Cocaine was detected in the plasma until 15 min after intranasal and 30 min after oral administration, but peak plasma concentrations were similar after both routes. The subjective "highs" in the Ss were greater after oral than after intranasal administration. (PsycINFO Database Record (c) 2006 APA, all rights reserved)



Just got this file for Jatelka. I thought this debate was open and shut but apparently not. Theres some other related articles that would be of use to this debate but I only had the time for the one at the moment.


In that case, anyone have experience with oral consumption of cocaine? A friend of swims got irritated that his nasal spray bottle was close to done and not working well so he just chugged the rest of the coke and water, but everyone was drunk and swim didn't remember to ask if he felt any effects from it during the night.

Reputation Comments on this post:

The subjective "highs" in the Ss were greater after oral than after intranasal administration. - interesting p...

[WrtngCocaineTutorial]

I've got no experience of oral administration on my own , but I've read quite a bit about it:

The bioavailibility of cocaine when taken orally: 20-30%
The bioavailibility of cocaine when taken orally Intranasaly: 20-30%

From Gold,¹ Table 16.5, p209

The problem with cocaine and oral administration is that digestive fluids destroys part of it.

The thing is, that in this investigations they have not used anything to facilitate absorption..

Sugar and alcohol helps absorption*, and will make more than 20-30% of the cocaine reach the bloodstream. This is because it's absorbed quicker, and the digestive fluids don't have the same amount of time to destroy it.

A cordial is a good choice to mix it in. High in both sugar and alcohol.

But it's advised to not make it a habit, because cocaine is hard on the stomach if taken every day

*Adam Gottlieb - Pleasures of Cocaine: If You Enjoy : This Book May Save Your Life,

[Bajeda]

Title: Intranasal and oral cocaine kinetics.
Author: Wilkinson, P
Add.Author / Editor: Barash, P Byck, R Van Dyke, C Jatlow, P
Citation: Clin Pharmacol Ther.
Volume: 27,
Issue: 3,
Date: 1980 05 14,
Pages: 386-94
Year: 1980
Abstract: Plasma cocaine levels were determined in 7 subjects after intranasal and oral cocaine. Intranasal doses of 0.19, 0.38, 0.75, 1.5, and 2.0 mg/kg were given as a 10% aqueous solution; 0.38 mg/kg was given as crystalline cocaine HCl. Oral cocaine was administered in doses of 2.0 and 3.0 mg/kg. Intranasal cocaine kinetics were described by a 1-compartment open model with 2 consecutive first-order input steps and first-order elimination. Oral cocaine disposition was described by a 1-compartment open model with a lag time followed by a single first-order input phase and first-order elimination. The mean elimination half-life (t 1/2) for cocaine by the intranasal route to 7 subjects was 75 +/- 5 min (mean +/- SE). The mean t 1/2 after oral administration to 4 subjects was 48 +/- 3 min. The relative bioavailability [as determined by the area under the concentration-time curve (AUC)] for the 2.0-mg/kg dose by the intranasal and oral routes was not different. There was a linear increase in AUC with increasing intranasal dose.



Title: Cocaine disposition in saliva following intravenous, intranasal, and smoked administration.
Author: Cone, E J
Add.Author / Editor: Oyler, J Darwin, W D
Citation: J Anal Toxicol.
Volume: 21,
Issue: 6,
Date: 1997 11 19,
Pages: 465-75
Year: 1997
Abstract: Saliva concentrations of cocaine, benzoylecgonine, ecgonine methyl ester, and anhydroecgonine methyl ester were measured by gas chromatography-mass spectrometry in six healthy male subjects following cocaine administration by the intravenous, intranasal, and smoked routes of administration. Cocaine appeared in saliva rapidly following all routes of administration. Saliva/plasma (S/P) ratios were generally greater than 1, and there was evidence of moderate to extreme contamination of saliva by cocaine immediately following intranasal and smoked routes of administration. Contamination of the oral cavity and saliva cleared rapidly. Saliva obtained 2 h after dosing appeared to be free of contamination and demonstrated S/P ratios comparable with intravenous administration. Benzoylecgonine and ecgonine methyl ester concentrations were consistently low and were only comparable with cocaine concentrations at times when cocaine concentrations had declined to below 100 ng/mL. Anhydroecgonine methyl ester was detectable in saliva following smoked drug administration, but it was quickly cleared. Terminal half-life estimates for cocaine administered by the intranasal and smoked routes were significantly shorter in saliva compared with those measured in plasma. Half-life estimates following intravenous administration tended to be lower for saliva than plasma, but the differences were not significant. The duration of pharmacologic effects was generally the same as or shorter than detection times of cocaine in plasma and saliva. Overall, the study demonstrated the usefulness of saliva as a test matrix for the detection and measurement of cocaine following administration by different routes of administration.



These were the most applicable articles concerning the topic at hand in this thread, but unfortunately I couldn't get the pdfs for them so here are the abstracts for you to peruse.

[pankreeas]

Just before this thread drops off the face of this earth again, swim would like to hear anyone else' experiences via the oral method if swiy is so inclined.

[Nicaine]

Originally Posted by pankreeas

Just before this thread drops off the face of this earth again, swim would like to hear anyone else' experiences via the oral method if swiy is so inclined.

It's not ideal, which is why people snort cocaine instead of eating it.

[pankreeas]

well it's ideal for swim as he had a rhinoplasty 2 years back for a deviated septum (which is in no way drug related) swim was born with the condition, and everytime he puts anything up the nostril's he ends with a good 3-4 hour tearjerking burn once the anesthetic effects wears off.

~~~~~back to the first time doing it~~~~~

Swim; as anyone, when in such pain from nothing even close to a binge (maybe 4 absolutely tiny "federlines" which swim's buddies calls it (hinting at the rest of his Kevin's post-brittany life.) First thing one thinks is wtf's this S#1T cut with.. so swim immediately asked the other 6-10 people who accompanied swim during the the first few times (up until 3 months ago swim had never met lady coca) if any of the lot experienced this nostril burn which damn near drove swim to the brink of madness. Nope... just this lone swim.

So after a couple more times just to be sure.. that finalized it. Never again up swims nose. Crack is not an option, nor is any sort of freebase, iv, ugh no, so coca-coctail so far seems ideal

[Nicaine]

Originally Posted by pankreeas

well it's ideal for swim as he had a rhinoplasty 2 years back for a deviated septum (which is in no way drug related) swim was born with the condition, and everytime he puts anything up the nostril's he ends with a good 3-4 hour tearjerking burn once the anesthetic effects wears off.

SWIM recommends dissolving it in water and plugging it up the rear end, if SWIY can get past the taboos associated with it. Should be more effective than either oral or snorting, but would take some practice (particularly getting the ratio of cola:water right, as it's a vasoconstrictor and will irritate the colon). Try a search and check out the various threads on rectal administration. It works extremely well, and nobody has to know.

[pankreeas]

what method would swiy think would have detremental effects in the organs, Up the pooper or down the chute? Swim is thinkinin it would be better to do the 1st route as it will help it to go straight to the lower intestine.

[Nicaine]

Originally Posted by pankreeas

what method would swiy think would have detremental effects in the organs, Up the pooper or down the chute? Swim is thinkinin it would be better to do the 1st route as it will help it to go straight to the lower intestine.

In SWIM's opinion, if it's diluted enough (don't use a really strong solution), up the poop chute is the best choice. SWIY should be prepared to experiment though in order to get the whole technique right... it won't be either as easy or socially acceptable as snorting or eating.

[MadShroomer]

also, note thatthere is a herbal liquor called "AQWA" that has 32 or 40g of coca leafs (.3-1.6g cocain) and I believe that cocaine and ethanol for some sort of bind called cocanethylen or somethin i forget. Liquor Barn doesn't stock it so i'll have to find some where else ... supposedly legal in US. i guess its for the same reason that COKE has coca leaf "flavor" so yeah....

[pankreeas]

Well since this threas has been revived, swim will mention that he has tried tried the oral cola concoction a few more times, however has decided to make it a very occasional thing as the reprocusions on his mid section become apparent quite quickly.

Reputation Comments on this post:

With ya on this 1

[MadShroomer]

sWIM had seen some 'agwa' for sale online. apparently its legal to selli nthe US despite haveing 32 grams worth of coca leafs infused along with abunch of other herbs.
The cocaine content of the leaves ranges from O.1% to 0.9%. so..
32mg - 288mg kinda a large gap. there is a AGWA something 40 that has40 grams coca leaf that apparently isonly available in europe...
40mg - 360mg wich is a tad more. Course acup of "matede coca" is about 10mg-90mg or so...that reminds SWIM, his cat needs some more tea..