DXM to reduce opiate tolerance

[Tortoise]

Mrs Jones would like to know if anybody knows of somebody who has used DXM in attempt to reduce their opiate tolerance. The theory is that it works to a minor extent but she would really like to hear some testimonials....

Anyswiys?

[thealexcometh]

plenty of people use dxm to potentiate opiates and swim can say it definitely enhances an opiate high by making it stronger/longer. One must not take huge amounts however, the key is to take a therapeutic dose.

[Tortoise]

That's interesting... by therapuetic, does Swiy mean 30mg? Mrs Jones will probably try that next time. I suspect that would need to be taken about 30 or 40 minutes before her opiate of choice?

I was however referring to the use of DXM as a means of reducing Mrs Jones' tolerance. Does anybody know of somebody who has had success with it for this purpose?

[csharpprogrammer]

Originally Posted by Tortoise

That's interesting... by therapuetic, does Swiy mean 30mg? Mrs Jones will probably try that next time. I suspect that would need to be taken about 30 or 40 minutes before her opiate of choice?

I was however referring to the use of DXM as a means of reducing Mrs Jones' tolerance. Does anybody know of somebody who has had success with it for this purpose?

Exactly.

[eltimmy]

THE EFFECT OF DEXTROMETHORPHAN IN PREVENTING THE DEVELOPMENT AND IN TREATING THE EXPRESSION OF
WITHDRAWAL SYNDROME DUE TO PASSIVE-ADDICTED TO MORPHINE IN THE NEONATAL RATS

Abstract Author(s):
G.C.Yeh1,2, G.L.Shui2, C.L.Hu3. P.L.Tao4
Affiliation:
1Department of Pediatrics, 2Graduate Institute of Medical Science, 3Graduate Institute of Cell and Molecular Biology, Taipei Medical College, 4Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan.

Abstract Text:

Dextromethorphan (DM), a common used antitussive agent, has been proved to effectively attenuate or prevent N-methyl-D-aspartate (NMDA) receptor mediated neuropathologies by acting as a selective NMDA receptor noncompetitive antagonist. It has been reported that NMDA receptor antagonists, including DM, can attenuate the expression of the morphine withdrawal syndrome in adult animals. Thus, we tested whether this drug could also be effective in the withdrawal syndrome in the neonatal animals. We sub-cutaneously injected female Sprague-Dawley rats with escalating dosage of morphine since a week before mating till the end of first month after gave birth to their offspring. Control rats received normal saline only. The offspring which passive addicted to morphine from the dam rats had higher mortality rate and lower birth weight, and developed overt behavioral change manifested as apparent and frequent abdominal stretching after single injection of naloxone (1 mg/kg). Pretreatment of DM directly on the neonatal rats could abolish the naloxone-induced behavioral change without apparent side effect. We also found that pre-natally injected the dam rats with DM could prevent the naloxone-induced behavioral
change in the offspring born to morphine-treated dam rats. This result indicated that DM may be of usefulness in preventing or treating the morphine-withdrawal syndrome developed in newborn period.
---

Published in: Eur J Pharmacol 2002 Mar 1;438(1-2):99-105 Glick SD, Maisonneuve IM, Kitchen BA, Fleck MW.

Center for Neuropharmacology and Neuroscience, Albany Medical College (MC-136), 47 New Scotland Avenue, 12208, Albany, NY, USA

Abstract:

Quote:
The iboga alkaloid ibogaine and the novel iboga alkaloid congener 18-methoxycoronaridine are putative anti-addictive agents. Using patch-clamp methodology, the actions of ibogaine and 18-methoxycoronaridine at various neurotransmitter receptor ion-channel subtypes were determined. Both ibogaine and 18-methoxycoronaridine were antagonists at alpha3beta4 nicotinic receptors and both agents were more potent at this site than at alpha4beta2 nicotinic receptors or at NMDA or 5-HT receptors; 18-methoxycoronaridine was more selective in this regard than ibogaine. In studies of morphine and methamphetamine self-administration, the effects of low dose combinations of 18-methoxycoronaridine with mecamylamine or dextromethorphan and of mecamylamine with dextromethorphan were assessed. Mecamylamine and dextromethorphan have also been shown to be antagonists at alpha3beta4 nicotinic receptors. All three drug combinations decreased both morphine and methamphetamine self-administration at doses that were ineffective if administered alone. The data are consistent with the hypothesis that antagonism at alpha3beta4 receptors is a potential mechanism to modulate drug seeking behavior. 18-methoxycoronaridine
apparently has greater selectivity for this site than other agents and may be the first of a new class of synthetic agents acting via this novel mechanism to produce a broad spectrum of anti-addictive activity.

[Tortoise]

Thanks eltimmy. That's very interesting.

Does anybody know someone who has any personal experience with it though?

[merc11292]

yea swim has personal experience, swim took 30mg of hydrocodone, and 30-60mg's of dxm swim couldnt figure out the dossage on the bottle it was 30 or 60, not sure which. anyway, it makes the experience much more intense, swim got some scary chest pain with it, it made it taper off slower too swim remembers having a nice buzz for about 7 hours, swim also took tagamet and grapefruit juice with the hydro and dxm tho

i read an article on how theyve used dxm in the past too slow morphine addiction in patents who need it for pain, i believe it both slows the tolerence and makes it more potent

if swiy tries it though be careful a kid in my town OD'ed on heroin and dxm the dxm made the heroin more potent and killed him, now he has golf tournament named after him, but hes in grave...so be carefull