Tianeptine is an Opiate?

[Broshious]

SWIM tried taking a megadose of Tianeptine(250mg) to see what they effects were as a few people have been reported to have abused it. Turns out that it feels like an opiate. SWIM got the itches, had itty bitty pupils, and felt pretty damn good. Afterwards SWIM found this from the website for a company that is trying to get Tianeptine approved for IBS(Irritable Bowel Syndrome):


"Tianeptine also binds to the ?-opiate receptor, where it has agonist activity that triggers antinociceptive activity."

[dr ACE]

according to 'wikipediea' it's a type of chemical thats related to tricyclic AD meds,sounds like an interesting medication good for anxiety


http://en.wikipedia.org/wiki/Tianeptine

[eltimmy]

Yeah, it binds to the opiate receptor. I'd be careful using this regularly at high doses for that purpose, of course, since it's certainly not "clean" in terms of the other effects (for instance, I would expect a stimulant effect from high doses) and problems may arise. There are a few cases of massive tianeptine dosing (abuse or suicide attempts), none of which to my knowledge produced severe long-term toxicity.

p.s. You would call tianeptine an "opioid". ;P

[dr ACE]

Originally Posted by eltimmy

p.s. You would call tianeptine an "opioid". ;P

can you expand on that?

[Lehendakari]

Tianeptine is a SSRE (selective serotonin reuptake enhancer) works by stimulating the reuptake of serotonin oppsed action to normal AD's (SSRI). SWIM was very interested in this chemical and its cousin amineptine: http://en.wikipedia.org/wiki/Amineptine.

Both are expensive and hard to find but SWIM has red good reports about them.

[eltimmy]

can you expand on that?

Strictly speaking, an "opiate" is a narcotic alkaloid actually derived from opium and also traditionally the semisynthetic derivatives of morphine -- morphine, codeine, thebaine; and by the second definition, heroin (diacetylmorphine), hydromorphone, hydrocodone, oxycodone, oxymorphone, etc.

"Opioids" are synthetic, not from morphine or poppy but with activity at the opiate receptors. Levemethorphan, buprenorphine, meperidine, fentanyl, propoxyphene, methadone ... tianeptine.

It's not a big deal. :P

[eltimmy]

Lehendakari: I am extremely interested in amineptine as well. A dopamine reuptake inhibitor with low affinity for the norepinephrine pumps? Count me in! Sounds perfect. Think methylphenidate without the adrenergic effects ...

It is still available from at least one obvious, expensive source (and apparently extremely rare elsewhere for some reason -- you'd think that it would sell extremely well among the nootropic user set* if someone synthesized a shitload of it. In the U.S. at least, you could still technically legally import a three-month supply of this for personal use -- it's not regulated.)

* many of whom were drawn to these things in the first place because of issues like inattention

[dr ACE]

from what wikiepidea has to say about amineptine it sounds like it has interesting effects, but there seems to be other motivations behinds its restrictions other than 'abuse potential'.check out the side effects could have dangerous consequences for certain individuals

[Lehendakari]

It apparenly caused liver failure yes, but I think the main reason of banning it was the great effects it had on depressed people and the fact that it was a French company producing it and it could bring down the big USA and UK Pharma companys selling shit like prozac and paxil......



That's just my opinion and I could be wrong, but they are doing the same with tianeptine. Apparently is effective and has a very low side effect profile but doctors won't prescribe it.

I started a threat about amineptine in the "varios drugs forum" but apparently the was no experiences.....

[dr ACE]

[QUOTE=Lehendakari;318842]It apparenly caused liver failure yes, but I think the main reason of banning it was the great effects it had on depressed people and the fact that it was a French company producing it and it could bring down the big USA and UK Pharma companys selling shit like prozac and paxil......QUOTE]

that's a very interesting perspective,didn't think of that. The government loves to think it has control over its citizens,and the medications 'they' think are safe for use.but the reality is the govenment can bend the truth and make good things bad and vice versa.little respect do 'they' show do peoples intelligence and values

[Befrank]

Hello,

I have recently come across this drug and am currently dosed. I will post any information that may be usefull when I have had an opportunity to evaluate the effects of said "megadose". This is my first experience with this rare(usa) chemical. Also I would like to thank those who posted the .pdf as it educated me and allowed me to move forward.
Time 7:30pm Est.

Frank

[Befrank]

Tianeptine is an Opiate?
This reporters opinion is no.

Its effects were noticable after 30mins.
dose:
20x 12.5mg Stablon chewed and eaten (time) 7:30pm
2x roxy m/30mg insufflated 9:00pm
1x oxy 80mg insufflated 11:00pm


Experiance was mild and mellow. I was able to drive and function normally.
I would however, not include this drug tianeptine(stablon) in your opiates catagory. I was not disapointed with the overall mood enhancment but it was not as pronounced as I would have liked and I found it easy to forget I had taken such a large dose of an unknown drug.

Not only was I able to function normally but, I also won my weekly Texas hold-em game. And those guys are no chumps; so cognatively speaking I was hitting on all cylinders.

So since I have procured 100's I will take them again tonight.......

via con dios
Frank

[eltimmy]

The hepatic side effects you reference are extremely rare. Compared to the profile of, say, aspirin (of which numerous people in the U.S. die every year) amineptine is very safe. Compared to many other psychiatric medications (tricyclics, antidepressants, and psychostimulants alike) its profile is also extremely favorable. It is not a good reason to restrict a medication that apparently was useful for so many, and it is not a good reason to interfere with SWIM's personal use.